ChemicalBook >> CAS DataBase List >>Pazufloxacin

Pazufloxacin

Pazufloxacin structure

CAS No.: 127045-41-4

Chemical Name:: Pazufloxacin

Synonyms: T-3761;ALKALYL;PAZUFLOXAXIN;Pazufloxacin;Pazufloxacine;PAZUFLOXACIN 98+%;Pazufloxacin318.3;PAZUFLOXACIN(ALKALYL);Pazufloxaxin mesilate;Pazufloxacinmyesylate

CBNumber:: CB2423188

Molecular Formula:: C16H15FN2O4

Molecular Weight:: 318.3

MDL Number:: MFCD00865012

MOL File:: 127045-41-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:27:24

Product description	Number	Pack Size	Price
Pazufloxacin VETRANAL	34213	25mg	$222
Pazufloxacin	AP65124	0.05g	$375
Pazufloxacin	AP65124	0.1g	$500
Pazufloxacin	AP65124	0.25g	$750
Pazufloxacin	AP65124	0.5g	$937.5
More product size

Request For Quotation

Pazufloxacin Properties

Melting point	269-271°C
alpha	D25 -88.0° (c = 0.5 in 0.05N aq NaOH)
Boiling point	531.5±50.0 °C(Predicted)
Density	1.56
storage temp.	2-8°C
solubility	Aqueous Base (Slightly, Sonicated), DMSO (Slightly, Heated), Methanol (Slightly)
pka	5.05±0.40(Predicted)
color	Off-White to Pale Yellow
Major Application	clinical testing
InChI	1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)/t7-/m0/s1
InChIKey	XAGMUUZPGZWTRP-ZETCQYMHSA-N
SMILES	C[C@H]1COc2c3N1C=C(C(O)=O)C(=O)c3cc(F)c2C4(N)CC4
CAS DataBase Reference	127045-41-4(CAS DataBase Reference)
FDA UNII	4CZ1R38NDI
ATC code	J01MA18
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332
Precautionary statements	P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn,C,F
Risk Statements	20/21/22-34-11
Safety Statements	36/37-45-36/37/39-26-16
WGK Germany	3
RTECS	UU8815300
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral
Toxicity	LD50 i.v. in male mice: >500 mg/kg (Todo)

Pazufloxacin price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	34213	Pazufloxacin VETRANAL	127045-41-4	25mg	$222	2026-04-30	Buy
Biosynth	AP65124	Pazufloxacin	127045-41-4	0.05g	$375	2026-06-04	Buy
Biosynth	AP65124	Pazufloxacin	127045-41-4	0.1g	$500	2026-06-04	Buy
Biosynth	AP65124	Pazufloxacin	127045-41-4	0.25g	$750	2026-06-04	Buy
Biosynth	AP65124	Pazufloxacin	127045-41-4	0.5g	$937.5	2026-06-04	Buy

Product number	Packaging	Price	Buy
34213	25mg	$222	Buy
AP65124	0.05g	$375	Buy
AP65124	0.1g	$500	Buy
AP65124	0.25g	$750	Buy
AP65124	0.5g	$937.5	Buy

Pazufloxacin Chemical Properties,Uses,Production

Description

Pazufloxacin is a fluoroquinolone with a 1-aminocyclopropyl substituent at C10 position. The presence of aminoacyl group at C-10 is a unique feature of the molecule imparting potent broad spectrum activity against gram-positive and gram-negative bacteria. This activity is based on the inhibition of bacterial DNA gyrase.
Pazufloxacin is used as an injectable antibiotic with bacterial effect against cephalosporin-resistant, carbapenem-resistance, and aminoglycoside resistant strains of bacteria. The adverse effects of pazufloxacin, such as drug-induced convulsion and hypotension are less than those of other conventional injectable fluoroquinolones.

References

[1] A. Vora, Pazufloxacin, tracked from www.japi.org on 16.07.2017
[2] Jeffrey K. Aronson, Meyler’s Side Effects of Antimicrobial Drugs, 2009
[3] Satoshi Watabe, Yoshiaki Yokoyama, Kazuyuki Nakazawa, Kimikazu Shinozaki, Rika Hiraoka, Kei Takeshita and Yukio Suzuki, Simultaneous measurement of pazufloxacin, ciprofloxacin, and levofloxacin in human serum by high-performance liquid chromatography with fluorescence detection, Journal of Chromatography B, 2010, vol. 878, 1555-1561

Description

Pazufloxacin is a novel quinolone marketed for the treatment of bacterial infections in Japan. This tricyclic fluoro-quinolone can be synthesized in 11 steps from commercially available 2,3,4,5tetrafluorobenzoic acid. The cyclopropyl substituent is first introduced in 6 steps including 4-F-substitution with tert-butylcyanoacetate, decarboxylation, aa alkylation with 1 ,Zdibromoethane, partial nitrile hydrolysis and Hoffmann-rearrangement. The pyridoxazine ring is then introduced in 5 steps including 6-ketoester formation and pryridoxazine annulation. Pazufloxacin displays a broad spectrum activity against Grampositive and Gram-negative bacteria, although it is less active that ciprofloxacin against pneumococci and is not active against ciprofloxacin-resistant isolates. In patients with gonococcal urethritis a high prevalence of fluoroquinolone-resistant N. gonorrhoeae isolates with the Ser-91-to-Phe mutation in GyrA was observed. However, good clinical responses have been seen in clinical trials of patients with urinary tract infections and to a lesser extent with respiratory tract infections. Pazufloxacin is mainly excreted in urine with a short half-life (2-2.5 h). It has a phototoxicity equal to that of ciprofloxacin and its adverse effect profile resembles that of other quinolones.

Originator

Toyama (Japan)

Uses

Pazufloxacin is a potential antimicrobial and/or antiviral agent.

Uses

antibactierial

Definition

ChEBI: LSM-5745 is a member of quinolines.

brand name

Pasil, Pazucross

Pharmaceutical Applications

A tricyclic fluoroquinolone, formulated as mesylate and hydrochloride salts for oral or parenteral use or as a methane sulfonate (eye ointment).
It displays good activity in vitro against methicillin susceptible Staph. aureus (MIC 0.2 mg/L), but is inactive against Str. pyogenes, Str. pneumoniae (MIC ≥4 mg/L) and enterococci. L. pneumophila is inhibited by 0.03 mg/L. Activity against Enterobacteriaceae, fastidious Gram-negative bacilli, Ps. aeruginosa and Acinetobacter spp. is similar to that of ofloxacin. It is weakly active against Sten. maltophilia and Burkholderia cepacia (MIC c. 2 mg/L). Against M. tuberculosis, MICs range from 0.8 to 4 mg/L. It is inactive against anaerobes.
After oral doses of 100 or 400 mg, peak plasma concentrations range from 0.94 mg/L (100 mg) to 4.5 mg/L (400 mg) after <1 h. The apparent elimination half-life is around 2 h. Most of the administered dose is eliminated in urine, about 70% within 24 h. Four metabolites have been reported. In elderly patients, according to the renal function, the peak plasma concentration may be elevated (up to 5.6 mg/L) and significantly delayed (2–6 h). The plasma protein binding ranges from 17% to 28%.

Pazufloxacin Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole DE Di-tert-Butyl malonate Sodium azide Ethyl 2,3,4,5-tetrafluorobenzoate

Methanesulfonic acid Sodium sulfite Trifluoroacetic acid Paraformaldehyde 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide

Diphenyldiazomethane Dimethyl sulfide Ethyl chloroformate Ethyl acetate N,N-Dimethylformamide dimethyl acetal

1of3

Preparation Products

Pazufloxacin Suppliers

Global( 190)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20582	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15083	58
Baoji Guokang Healthchem Co., Ltd.	+86-0917-3909592 +86-13892490616	gksales1@gk-bio.com	China	9071	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Healthchem Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Pazufloxacin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-19	Pazufloxacin 127045-41-4		10mg	90%+	10g	Guangzhou PI PI BIOTECH INC
2025-11-18	Pazufloxacin USP/EP/BP 127045-41-4	$1.10	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2025-06-27	Pazufloxacin 127045-41-4		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

Pazufloxacin
127045-41-4
90%+
Guangzhou PI PI BIOTECH INC

Pazufloxacin USP/EP/BP
127045-41-4
$1.10
99.9%
Dideu Industries Group Limited

Pazufloxacin
127045-41-4
99%
Hebei Chuanghai Biotechnology Co., Ltd

127045-41-4(Pazufloxacin)Related Search:

Methyl salicylate 2-Aminopyridine 4-Dimethylaminopyridine Tribenuron methyl Lithium diisopropylamide

METSULFURON METHYL DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Kresoxim-methyl 3-Aminopyridine Balofloxacin

TROVAFLOXACIN Sparfloxacin Tosufloxacin Clinafloxacin Sparfloxacin

Thiophanate-methyl Methyl 3'-FLUORO-4'-METHYLACETOPHENONE

1of4

PAZUFLOXAXIN T-3761 (s)-yclopropyl)-9-fluoro-3-methyl-7-oxo Pazufloxacinmyesylate (3S)-10-(1-AMINOCYCLOPROPYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID ALKALYL Pazufloxaxin mesilate PAZUFLOXACIN 98+% (S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid PAZUFLOXACIN (PREPARATION FOR PAZUFLOXACIN MESILATE) PAZUFLOXACIN(ALKALYL) 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo- (9CI) (-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)- (9CI) 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)- (S)-10-(1-AMINOCYCLOPROPYL)-9-FLUORO-3-METHYL-7-OXO-3,7-DIHYDRO-2H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC ACID 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10-(1-aminocyclopropyl)-9- fluoro-3-methyl-7-oxo-, (S)- Pazufloxacin318.3 Pazufloxacine (S)-10-(1-Aminocyclopropyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido(1,2,3-De)-1,4-Benzoxazine-6-Carboxylic Acid Pazufloxacin (S)-10-(1-aMinocyclopropyl)-9-fluoro-3-Methy... 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)- Pazufloxacin USP/EP/BP CAS No.127045-41-4 Pazufloxacin Pazufloxacin 100 μg/mL in Acetonitrile 127045-41-4 C37H63NO9 C16H15FN2O4 BacteriostaticAntibiotics ChinolonesAlphabetic PA - PENAnalytical Standards Pharmacology Standards Antibiotics Chemical Structure Chromatography P Principle API's