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Ethyl 4-chloroacetoacetate

Ethyl 4-chloroacetoacetate Structure
Ethyl 4-chloroacetoacetate structure
CAS No.
638-07-3
Chemical Name:
Ethyl 4-chloroacetoacetate
Synonyms
ETHYL 4-CHLORO-3-OXOBUTANOATE;Ethyl 4-chloro-3-oxobutyrate;4-CHLOROACETOACETIC ACID ETHYL ESTER;oroacetoacetate;AKOS BBS-00004336;Ethyl 4-chloroacetoa;4-Chloro-acetoacetic;Amlodipine Impurity R;Amlodipine Impurity 66;Oxiracetam Impurity 15
CBNumber:
CB2424408
Molecular Formula:
C6H9ClO3
Molecular Weight:
164.59
MDL Number:
MFCD00000939
MOL File:
638-07-3.mol
MSDS File:
SDS
Last updated:2026-05-28 00:28:49
Product description Number Pack Size Price
Ethyl 4-chloroacetoacetate 95% 180769 50g $63.1
Ethyl 4-chloroacetoacetate 95% 180769 250g $129
Ethyl 4-Chloroacetoacetate >95.0%(GC) C0911 25g $25
Ethyl 4-Chloroacetoacetate >95.0%(GC) C0911 500g $162
Ethyl 4-Chloroacetoacetate TRC-E901800-500MG 500mg $64
More product size
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Ethyl 4-chloroacetoacetate Properties

Melting point -8 °C
Boiling point 115 °C/14 mmHg (lit.)
Density 1.218 g/mL at 25 °C (lit.)
vapor pressure 7hPa at 20℃
refractive index n20/D 1.452(lit.)
Flash point 206 °F
storage temp. 2-8°C
solubility 47.0g/l
form Liquid
pka 9.56±0.46(Predicted)
color Clear colorless to pale reddish-yellow
PH 2.9 (10g/l, H2O, 20℃)
explosive limit 1.8%(V)
Water Solubility 47.5 g/L (20 ºC)
BRN 1761275
InChI 1S/C6H9ClO3/c1-2-10-6(9)3-5(8)4-7/h2-4H2,1H3
InChIKey OHLRLMWUFVDREV-UHFFFAOYSA-N
SMILES CCOC(=O)CC(=O)CCl
LogP 0.68 at 25℃
CAS DataBase Reference 638-07-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 5AE82250CM
NIST Chemistry Reference Butanoic acid, 4-chloro-3-oxo-, ethyl ester(638-07-3)
EPA Substance Registry System Ethyl 4-chloroacetoacetate (638-07-3)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)Environment (GHS09)
GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H301+H311-H314-H411
Precautionary statements  P270-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  T,N,C
Risk Statements  25-34-51/53-24/25-36
Safety Statements  26-36-45-61-36/37/39-27
RIDADR  UN 2922 8/PG 2
WGK Germany  3
RTECS  AK5110000
F  8-10-19-21
TSCA  TSCA listed
HazardClass  8
PackingGroup  II
HS Code  29183000
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Oral
Aquatic Chronic 2
Eye Dam. 1
Skin Corr. 1B
REACH Registrations Active
NFPA 704
0
4 0

Ethyl 4-chloroacetoacetate price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 180769 Ethyl 4-chloroacetoacetate 95% 638-07-3 50g $63.1 2026-04-30 Buy
Sigma-Aldrich 180769 Ethyl 4-chloroacetoacetate 95% 638-07-3 250g $129 2026-04-30 Buy
TCI Chemical C0911 Ethyl 4-Chloroacetoacetate >95.0%(GC) 638-07-3 25g $25 2026-04-30 Buy
TCI Chemical C0911 Ethyl 4-Chloroacetoacetate >95.0%(GC) 638-07-3 500g $162 2026-04-30 Buy
TRC TRC-E901800-500MG Ethyl 4-Chloroacetoacetate 638-07-3 500mg $64 2026-06-03 Buy
Product number Packaging Price Buy
180769 50g $63.1 Buy
180769 250g $129 Buy
C0911 25g $25 Buy
C0911 500g $162 Buy
TRC-E901800-500MG 500mg $64 Buy

Ethyl 4-chloroacetoacetate Chemical Properties,Uses,Production

Description

Ethyl 4-chloroacetoacetate is a chemical compound, which for the ethyl esters of acetoacetic acid belongs. It is a starting material in various syntheses.

Chemical Properties

Ethyl 4-chloroacetoacetate is colorless to pale reddish-yellow clear liquid

Uses

Ethyl-4-chloracetoacetate (CAAEt) is used as intermediate for organic syntheses, e.g. ethyl 4-chloro-3-arylaminocrotonates, diethyl succinylsuccinate, 2-alkyl-4-hydroxy-6-chloromethylpyrimidines, 4- chloromethylcoumarines. Product Data Sheet

Uses

Ethyl 4-chloroacetoacetate is used as a precursor in the preparation of phosphorous ylides. It finds application in regular film coating, pharmaceutical coating and formulation.

Preparation

Preparative Methods of Ethyl 4-chloroacetoacetate: the industrial production of the esters is made exclusively by chlorination of diketene followed by reaction of the intermediate acid chloride with the corresponding alcohol.[2]

Synthesis

Ethyl acetoacetate

141-97-9

Ethyl 4-chloroacetoacetate

638-07-3

GENERAL PROCEDURE: To an anhydrous THF (2 mL) solution of diisopropylamine (340 μL, 2.4 eq.) in a flame-dried round-bottomed flask under an argon atmosphere at 0 °C, n-butyllithium (1.4 mL, 1.6 M hexane solution, 2.2 eq.) was slowly added and the reaction mixture was stirred at this temperature for 15 min. Maintaining the same temperature, a solution of THF (2 mL) in ethyl acetoacetate (1 mmol) was slowly added dropwise. The reaction mixture was cooled to -78 °C after continued stirring at 0 °C for 1 h. Methyl chlorosulfate (110 μL, 1.2 eq.) was subsequently added. After stirring at -78 °C for 30 min, the reaction was quenched by the addition of saturated aqueous ammonium chloride solution (5 mL). The mixture was extracted with dichloromethane (3 x 5 mL) and the organic phases were combined and dried over anhydrous magnesium sulfate. Evaporation of the solvent gave the target product ethyl 4-chloroacetoacetate.

Solubility in organics

Ethyl 4-Chloroacetoacetate is is soluble in most organic solvents. The ethyl ester (1a) is 12% enolized in the pure liquid, and highly enolized (60% in CCl4) in nonpolar solvents.[1]

storage

Ethyl 4-chloroacetoacetate is lachrymators of moderate toxicity; uses in a fume hood.

References

1. Rappoport, Z. The Chemistry of Enols; Wiley: New York, 1990; p 365.
2. Lonza AG; U.S. Patent 4 473 508, 1984 (CA 1985, 102, 5715).

Ethyl 4-chloroacetoacetate synthesis

141-97-9
638-07-3
Synthesis of Ethyl 4-chloroacetoacetate from Ethyl acetoacetate

Ethyl 4-chloroacetoacetate Preparation Products And Raw materials

Raw materials

Acetyl ketene Ethanol Chlorine METHANE Ethyl acetoacetate
Diisopropylamine Hexane Tetrahydrofuran Methyl chlorosulfonate n-Butyllithium

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Preparation Products

4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE 4-CHLOROMETHYL-6-METHYL-CHROMEN-2-ONE
Diethyl succinosuccinate 2-(6-METHOXY-1-BENZOFURAN-3-YL)ACETIC ACID 4-Thiazoleacetic acid, ethyl ester 6-(Chloromethyl)uracil (2-PHENYL-THIAZOL-4-YL)-ACETIC ACID
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Ethyl 4-(benzyloxy)-3-oxobutanoate DL-CARNITINE ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE

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Ethyl 4-chloroacetoacetate Suppliers

Global( 597)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49979 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5228 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
airuikechemical co., ltd. 		+86-18353166132 sales02@airuikechemical.com China 983 58
Shanghai Bojing Chemical Co.,Ltd. 		+86-86-02137122233 +8613795318958 bj1@bj-chem.com China 299 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +8618949832763 info@tnjchem.com China 2988 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Anhui Ruihan Technology Co., Ltd 		58
airuikechemical co., ltd. 		58
Shanghai Bojing Chemical Co.,Ltd. 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58

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Ethyl 4-chloroacetoacetate pictures 2026-06-06 Ethyl 4-chloroacetoacetate
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4-Chloroacetoacetic acid ethyl ester pictures 2026-06-03 4-Chloroacetoacetic acid ethyl ester
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Ethyl 4-Chloroacetoacetate pictures 2026-05-28 Ethyl 4-Chloroacetoacetate
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 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD

Ethyl 4-chloroacetoacetate Spectrum

Ethyl 4-chloroacetoacetate(638-07-3)MSEthyl 4-chloroacetoacetate(638-07-3)1HNMREthyl 4-chloroacetoacetate(638-07-3)13CNMREthyl 4-chloroacetoacetate(638-07-3)IR1Ethyl 4-chloroacetoacetate(638-07-3)IR2Ethyl 4-chloroacetoacetate(638-07-3)Raman

638-07-3(Ethyl 4-chloroacetoacetate)Related Search:

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Ethyl acetate Ethyl acrylate 2-Hexenoic acid, 4,5-dihydroxy-, (2E,4S,5R)- 2-Hexenoic acid, 4,5-dihydroxy- 1-Butanaminium, 4-methoxy-N,N,N-trimethyl-2,4-dioxo-, chloride (1:1)
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AKOS BBS-00004336 BUTANOIC ACID, 4-CHLORO-3-OXO-ETHYL ESTER ETHYL 4-CHLOROACETOACETATE ETHYL-GAMMA-CHLOROACETOACETATE Amlodipine Impurity 66 4-chloroacetoacetate reference substance 4-chloro-3-oxo-butanoicaciethylester 4-chloro-acetoaceticaciethylester 4-Chloroacetoacetic Acid Ethyl Ester Ethyl (Chloroacetyl)acetate (Chloroacetyl)acetic Acid Ethyl Ester Ethyl 4-Chloro-3-oxobutyrate 4-Chloro-3-oxobutyric Acid Ethyl Ester Ethyl 4-chloroacetoa Ethyl 4-chloroacetoacetate 95% Ethyl 4-chloroacetoacetate, 99%+ 4 - chlorine ethyl acetoacetate Acetoacetic acid, 4-chloro-, ethyl ester Ethyl4-chloroacetoacetate,97% 4-Chloro-acetoacetic Ethyl-4-chloracetoacetat 4-chloro-3-oxo-butanoic acid ethyl ester 4-CHLOROACETOACETIC ACID ETHYL ESTER 95% Ethyl (chloroacetyl)acetate Ethyl g-chloroacetoacetate Ethyl 4-chloroacetoacetate ,98% (Chloroacetyl)acetic acid ethyl ester 3-Oxo-4-chlorobutanoic acid ethyl 3-Oxo-4-chlorobutanoic acid ethyl ester 4-Chloro-3-oxobutyric acid ethyl ester Ethyl-4chloroacetaacetate Ethyl 4-chloroacetoacetate 95%/99% Ethyl 4-chloroacetoacetate, 98% 250GR Ethyl 4-chloroacetoacetate, 98% 50GR Ethyl-4-chIoroaoetoacetate Oxiracetam Impurity 15 Amlodipine Impurity R oroacetoacetate Ethyl 4-Chloroacetoacetate > Levocabastine Impurity 6 4-Chloroacetoacetate ethyl ester 4-Chloracetoacetic acid ethyl ester 4-Chloroacetyl Ethyl Acetate 4-CHLOROACETOACETIC ACID ETHYL ESTER Ethyl 4-chloro-3-oxobutyrate 4-Ethyl chloroacetoacetate ETHYL 4-CHLORO-3-OXOBUTANOATE 638-07-3 ClCH2COCH2CO2C2H5 KETONE Building Blocks Carbonyl Compounds C6 to C7 Esters Organic Building Blocks C6 to C7 Carbonyl Compounds Esters Aliphatics Pharmaceutical Intermediates Halogen compounds 1