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(R)-(+)-4-HYDROXY-2-PYRROLIDINONE

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE structure

CAS No.: 22677-21-0

Chemical Name:: (R)-(+)-4-HYDROXY-2-PYRROLIDINONE

Synonyms: RHPD;In1122 Impurity 78;Oxiracetam Impurity P;(R)-4-hydoroxyoyrolidone;4-hydroxy-R-2-pyrrolidine;(R)-4-HYDROXY-2-PYRROLIDONE;(r)-β-hydroxy-γ-butyrolactam;（R)+4-hydroxy-2-prrolidinone;(R)-4-hydroxy-2-pyrrolidione;(4R)-4-hydroxy-2-pyrrolidone

CBNumber:: CB2438434

Molecular Formula:: C4H7NO2

Molecular Weight:: 101.1

MDL Number:: MFCD00273364

MOL File:: 22677-21-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:17:34

Product description	Number	Pack Size	Price
(R)-(+)-4-Hydroxy-2-pyrrolidinone 97%	479160	1g	$114
(R)-(+)-4-Hydroxy-2-pyrrolidinone 97%	479160	5g	$417
(R)-(+)-4-Hydroxy-2-pyrrolidinone	H953070	1g	$1110
(R)-4-Hydroxypyrrolidin-2-one >98.0%	CS-W013709	100g	$1492
(R)-4-Hydroxypyrrolidin-2-one >98.0%	CS-W013709	25g	$521
More product size

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(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Properties

Melting point	156-160 °C
Boiling point	363.6±35.0 °C(Predicted)
Density	1.292±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Sparingly), Methanol (Slightly), Water (Sparingly)
pka	13.62±0.20(Predicted)
form	Powder
color	White to pale yellow
optical activity	[α]23/D +43°, c = 1 in ethanol
Water Solubility	Slightly soluble in water.
BRN	1524193
InChI	InChI=1S/C4H7NO2/c6-3-1-4(7)5-2-3/h3,6H,1-2H2,(H,5,7)/t3-/m1/s1
InChIKey	IOGISYQVOGVIEU-GSVOUGTGSA-N
SMILES	N1C[C@H](O)CC1=O
CAS DataBase Reference	22677-21-0(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38-38-37-36

Safety Statements

WGK Germany

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	479160	(R)-(+)-4-Hydroxy-2-pyrrolidinone 97%	22677-21-0	1g	$114	2025-07-31	Buy
Sigma-Aldrich	479160	(R)-(+)-4-Hydroxy-2-pyrrolidinone 97%	22677-21-0	5g	$417	2023-06-20	Buy
TRC	H953070	(R)-(+)-4-Hydroxy-2-pyrrolidinone	22677-21-0	1g	$1110	2021-12-16	Buy
ChemScene	CS-W013709	(R)-4-Hydroxypyrrolidin-2-one >98.0%	22677-21-0	100g	$1492	2021-12-16	Buy
ChemScene	CS-W013709	(R)-4-Hydroxypyrrolidin-2-one >98.0%	22677-21-0	25g	$521	2021-12-16	Buy

Product number	Packaging	Price	Buy
479160	1g	$114	Buy
479160	5g	$417	Buy
H953070	1g	$1110	Buy
CS-W013709	100g	$1492	Buy
CS-W013709	25g	$521	Buy

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

The (R)-enantiomer intermediate in the preparation of Oxiracetam

Uses

(R)-(+)-4-Hydroxy-2-pyrrolidinone intermediate in the preparation of Oxiracetam. Also used as enantiomeric intermediate for the asymmetric single isomeric drugs including antitumor, anesthetic, antipasmodic, anti-inflammatory or anti-HIV activity products.

Synthesis

In a 250mL four-necked flask, add 70mL of water and 2.5mL of triethylamine, stir well, and reduce the temperature to 5~10C. Add 5g of 2,4-dioxopyrrolidine hydrochloride under stirring, and add 2.77g of potassium borohydride. Add 5g of 2,4-dioxopyrrolidine hydrochloride under stirring, add potassium borohydride 2.77g. Hold at 5 for 0.5h, warm up to 25 and hold for 1h, concentrate under reduced pressure with a water bath temperature of 80, and concentrate to dryness. Add 5mL of methanol fusion crystallization at 20-25 overnight, filtration, washed with 10mL of methanol, dried in a vacuum at 50 dry 0.5h, the crude 3.42g, the content of 83.91% (mass fraction), folding purity yield of 69.23%. Chiral split preparation (R)-4-hydroxy-2-pyrrolidone.

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE synthesis

Synthesis of (R)-(+)-4-HYDROXY-2-PYRROLIDINONE from Butanoic acid, 4-amino-3-hydroxy-, ethyl ester, (3R)-

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Butanoic acid, 4-amino-3-hydroxy-, ethyl ester, (3R)- 2-Pyrrolidinone, 1-[(1S)-1-phenylethyl]-4-(phenylmethoxy)-, (4R)-

Preparation Products

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Suppliers

Global( 183)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Klong Industrial Co., Ltd	0086-519-68231162	info@klongchem.com	CHINA	131	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Klong Industrial Co., Ltd	58
Changzhou Ansciep Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from (R)-(+)-4-HYDROXY-2-PYRROLIDINONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-10-13	(R)-(+)-4-Hydroxy-2-pyrrolidinone 22677-21-0	US $3.00-9.00 / KG	0.1KG	99%	g-kg-tons, free sample is available	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2019-07-06	(R)-(+)-4-HYDROXY-2-PYRROLIDINONE 22677-21-0	US $1.00 / kg	1kg	95%-99%	as request	Career Henan Chemical Co

(R)-(+)-4-Hydroxy-2-pyrrolidinone
22677-21-0
US $3.00-9.00 / KG
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE
22677-21-0
US $1.00 / kg
95%-99%
Career Henan Chemical Co

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Spectrum

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE(22677-21-0)¹HNMR

22677-21-0((R)-(+)-4-HYDROXY-2-PYRROLIDINONE)Related Search:

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE (3R,4R)-1-Benzyl-3,4-dihydroxypyrrolidine-2,5-dione (S)-(+)-4-HYDROXY-2-PYRROLIDINONE,(S)-4-HYDROXY-2-PYRROLIDINONE,(S)-(-)-4-HYDROXY-2-PYRROLIDINONE 4-Hydroxy-2-pyrrolidinone (S)-(-)-3-hydroxy-2-pyrrolidinone

(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE 3-HYDROXY-2-PYRROLIDINONE (S)-1-BENZYL-4-HYDROXY-2-PYRROLIDINONE ALPHA-PYRIDOIN (R)-(+)-1-BENZYL-4-HYDROXY-2-PYRROLIDINONE,(R)-1-BENZYL-4-HYDROXY-2-PYRROLIDINONE

3-CYCLOPENTYL-4-OXO-10-OXA-3-AZA-TRICYCLO[5.2.1.0(1,5)]DEC-8-ENE-6-CARBOXYLIC ACID (3R,4S)-1-BENZYL-3,4-DIHYDROXY-2,5-PYRROLIDINEDIONE 4-OXO-3-PHENETHYL-10-OXA-3-AZA-TRICYCLO[5.2.1.0(1,5)]DEC-8-ENE-6-CARBOXYLIC ACID (+)-TARTRANIL 3-(2-DIETHYLAMINO-ETHYL)-4-OXO-10-OXA-3-AZA-TRICYCLO[5.2.1.0(1,5)]DEC-8-ENE-6-CARBOXYLIC ACID

3-(3-METHOXY-PROPYL)-4-OXO-10-OXA-3-AZA-TRICYCLO[5.2.1.0(1,5)]DEC-8-ENE-6-CARBOXYLIC ACID (S)-4-HYDROXY-2-PYRROLIDINONE-1-N-ACETIC ACID R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE

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(R)-(+)-4-HYDROXY-2-PYRROLIDINONE (R)-4-HYDROXY-2-PYRROLIDINONE (R)-4-HYDROXY-2-PYRROLIDONE (R)-BETA-HYDROXY-GAMMA-BUTYROLACTAM RHPD 2-PYRROLIDINONE, 4-HYDROXY-, (R) 4-hydroxy-R-2-pyrrolidine (r)-(+)-β-hydroxy-γ-butyrolactam (r)-β-hydroxy-γ-butyrolactam 2-Pyrrolidinone, 4-hydroxy-, (4R)- (R)-4-hydoroxyoyrolidone （R)+4-hydroxy-2-prrolidinone (R)-4-Hydroxy-pyrrolidin-2-one (4R)-4-Hydroxypyrrolidine-2-one (R)-4β-Hydroxypyrrolidine-2-one [4R,(-)]-4-Hydroxypyrrolidin-2-one (R)-4-hydroxy-2-pyrrolidione (4R)-4-hydroxy-2-pyrrolidone (4R)-4-Hydroxy-2-pyrrolidinone In1122 Impurity 78 Oxiracetam Impurity P (R)-(+)-4-Hydroxy-2-pyrrolidinone, 97%, (R)-(+)-4-Hydroxy-2-pyrrolidinone (R)-4-hydroxypyrrolidin-2-one, 98%min 22677-21-0 Chiral Building Blocks Asymmetric Synthesis Heterocyclic Building Blocks Pyrrolidines Pyrrole&Pyrrolidine&Pyrroline Amines Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Drug Intermediates