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ChemicalBook >> CAS DataBase List >>6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione

6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione

6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione Structure
6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione structure
CAS No.
712346-06-0
Chemical Name:
6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione
Synonyms
ELOVL6-IN-3;6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione;6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione;1H-Indole-2,4-dione, 3-(2,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-
CBNumber:
CB24446468
Molecular Formula:
C27H24F3N3O3
Molecular Weight:
495.49
MDL Number:
MOL File:
712346-06-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 16:31:51
Request For Quotation

6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione Properties

Boiling point 596.8±60.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
form Solid
pka -0.43±0.70(Predicted)
color White to off-white

6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0201517 ELOVL6-IN-3 99.19% 712346-06-0 5mg $173 2026-06-04 Buy
ChemScene CS-0201517 ELOVL6-IN-3 99.19% 712346-06-0 10mg $276 2026-06-04 Buy
ChemScene CS-0201517 ELOVL6-IN-3 99.19% 712346-06-0 25mg $552 2026-06-04 Buy
ChemScene CS-0201517 ELOVL6-IN-3 99.19% 712346-06-0 50mg $883 2026-06-04 Buy
ChemScene CS-0201517 ELOVL6-IN-3 99.19% 712346-06-0 100mg $1408 2026-06-04 Buy
Product number Packaging Price Buy
CS-0201517 5mg $173 Buy
CS-0201517 10mg $276 Buy
CS-0201517 25mg $552 Buy
CS-0201517 50mg $883 Buy
CS-0201517 100mg $1408 Buy

6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione Chemical Properties, Uses, Production

Uses

ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].

in vivo

ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1].
ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1].
ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1].

References

[1] Shimamura K, et al. 5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool. J Pharmacol Exp Ther. 2009;330(1):249-256. DOI:10.1124/jpet.109.150854
[2] Takahashi T, Nagase T, Sasaki T, et al. Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009;52(10):3142-3145. DOI:10.1021/jm900391x
[3] Zheng Junxia, Wu Zhiwei, Dai Mibei, Xu Zhihui, Li Xiaomei, Zhu Shanshan, Lin Chuyun, Hu Peijian, Zhang Luo, Huang Huarong, Zhao Suqing, Zhang Kun and Sun Pinghua, Quantitative Structure Activity Relationship Studies on a Novel Indolediones as Long Chain Fatty Acid Elongase 6 (ELOVL6) Inhibitors, Letters in Drug Design & Discovery 2011; 8(5) .

6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione Preparation Products And Raw materials

Raw materials

Preparation Products

6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione Suppliers

Global Suppliers ( 7)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Guangzhou Younan Technology Co., Ltd 020-82000279 18988941452 YN_research@163.com China 2984 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 5000 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29873 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
Guangzhou Younan Technology Co., Ltd 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ELOVL6-IN-3 pictures 2026-05-11 ELOVL6-IN-3
712346-06-0
 $339.00 10g TargetMol Chemicals Inc.

712346-06-0 (6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione) Related Search:

Morpholine, 2-phenyl-4-[6-[[cis-3-(1H-pyrazol-1-yl)cyclobutyl]oxy]-4-pyrimidinyl]-, (2S)- 3-(pyridin-2-ylsulfonyl)-N-(4-(trifluoroMethyl)phenyl)-8-azabicyclo[3.2.1]octane-8-carboxaMide 1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)- Mouse Serum Albumin 8-Azabicyclo[3.2.1]octane-8-carboxamide, 3-(2-pyridinylsulfonyl)-N-[4-(trifluoromethyl)phenyl]-
6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione 1H-Indole-2,4-dione, 3-(2,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)- 6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione ELOVL6-IN-3 712346-06-0