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4'-CHLORO-3-METHOXYCINNAMANILIDE

4'-CHLORO-3-METHOXYCINNAMANILIDE Structure
4'-CHLORO-3-METHOXYCINNAMANILIDE structure
CAS No.
472981-92-3
Chemical Name:
4'-CHLORO-3-METHOXYCINNAMANILIDE
Synonyms
SB 366791;SB366791, >98%;SB 366791;SB366791;SB-366791, 10 mM in DMSO;SB-366791, TRPV1 antagonist;4'-CHLORO-3-METHOXYCINNAMANILIDE;N-(3-METHOXYPHENYL)-4-CHLOROCINNAMIDE;4'-CHLORO-3-METHOXYCINNAMANILIDE(SB366791);3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide;(E)-3-(4-CHLOROPHENYL)-N-(3-METHOXYPHENYL)ACRYLAMIDE
CBNumber:
CB2449409
Molecular Formula:
C16H14ClNO2
Molecular Weight:
287.74
MDL Number:
MFCD01033818
MOL File:
472981-92-3.mol
MSDS File:
SDS
Last updated:2026-01-26 13:56:28
Product description Number Pack Size Price
SB-366791 ≥98% (HPLC), powder S0441 5mg $212
SB-366791 ≥98% (HPLC), powder S0441 25mg $837
SB-366791 B5762 25MG $132
SB-366791 B5762 100MG $362
SB-366791 ≥98% 11019 5mg $60
More product size
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4'-CHLORO-3-METHOXYCINNAMANILIDE Properties

Melting point 165-167℃
storage temp. Sealed in dry,Room Temperature
solubility DMSO: 13 mg/mL, soluble
form solid
color off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI 1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
InChIKey RYAMDQKWNKKFHD-JXMROGBWSA-N
SMILES COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
FDA UNII E8EY4M2N4H
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
HS Code  2924.29.7790
Storage Class 11 - Combustible Solids

4'-CHLORO-3-METHOXYCINNAMANILIDE price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S0441 SB-366791 ≥98% (HPLC), powder 472981-92-3 5mg $212 2025-07-31 Buy
Sigma-Aldrich S0441 SB-366791 ≥98% (HPLC), powder 472981-92-3 25mg $837 2025-07-31 Buy
TCI Chemical B5762 SB-366791 472981-92-3 25MG $132 2025-07-31 Buy
TCI Chemical B5762 SB-366791 472981-92-3 100MG $362 2025-07-31 Buy
Cayman Chemical 11019 SB-366791 ≥98% 472981-92-3 5mg $60 2024-03-01 Buy
Product number Packaging Price Buy
S0441 5mg $212 Buy
S0441 25mg $837 Buy
B5762 25MG $132 Buy
B5762 100MG $362 Buy
11019 5mg $60 Buy

4'-CHLORO-3-METHOXYCINNAMANILIDE Chemical Properties,Uses,Production

Description

SB-366791 (472981-92-3) is a potent (IC50 = 0.7 μM) and selective TRPV1 blocker.1,2 Selective for TRPV1 in a panel of 47 different binding assays.

Uses

N-(4-Methoxyphenyl)-4-chlorocinnamamide is a novel, potent, and selective cinnamide TRPV1 antagonist. Also a useful tool to further study the biology of TRPV1.

Uses

SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:

  • to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)
  • to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity
  • to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)

Definition

ChEBI: 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.

Biological Activity

Potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA 2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB 1 and CB 2 receptors, voltage-gated Ca 2+ channels and the hyperpolarization-activated current (I h ). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .

Biochem/physiol Actions

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.

storage

Store at RT

References

[1] M.J. GUNTHORPE . Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist[J]. Neuropharmacology, 2004, 46 1: Pages 133-149. DOI:10.1016/s0028-3908(03)00305-8
[2] ANGELIKA VARGA . Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat[J]. Neuroscience Letters, 2005, 385 2: Pages 137-142. DOI:10.1016/j.neulet.2005.05.015

4'-CHLORO-3-METHOXYCINNAMANILIDE Preparation Products And Raw materials

Raw materials

Preparation Products

4'-CHLORO-3-METHOXYCINNAMANILIDE Suppliers

Global( 138)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5742 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39042 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 8497 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58

View Lastest Price from 4'-CHLORO-3-METHOXYCINNAMANILIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SB-366791 pictures 2026-01-26 SB-366791
472981-92-3
 US $30.00-81.00 / mg 99.51% 10g TargetMol Chemicals Inc.
4'-CHLORO-3-METHOXYCINNAMANILIDE pictures 2024-10-22 4'-CHLORO-3-METHOXYCINNAMANILIDE
472981-92-3
 US $1.00 / g 1g 85.0-99.8% 20tons Career Henan Chemica Co
  • SB-366791 pictures
  • SB-366791
    472981-92-3
  • US $30.00-81.00 / mg
  • 99.51%
  • TargetMol Chemicals Inc.

4'-CHLORO-3-METHOXYCINNAMANILIDE Spectrum

4'-CHLORO-3-METHOXYCINNAMANILIDE(472981-92-3)1HNMR

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N-(3-METHOXYPHENYL)-4-CHLOROCINNAMIDE SB 366791 4'-CHLORO-3-METHOXYCINNAMANILIDE 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide (E)-3-(4-CHLOROPHENYL)-N-(3-METHOXYPHENYL)ACRYLAMIDE 2-Propenamide,3-(4-chlorophenyl)-N-(3-methoxyphenyl)- SB 366791;SB366791 SB366791, >98% 4'-CHLORO-3-METHOXYCINNAMANILIDE(SB366791) 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide SB-366791, TRPV1 antagonist SB-366791, 10 mM in DMSO 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propyleneamide 472981-92-3 C16H14NO2Cl Vanilloid/TRPV channel API