4-(3-Methylphenyl)benzaldehyde
- CAS No.
- 400744-83-4
- Chemical Name:
- 4-(3-Methylphenyl)benzaldehyde
- Synonyms
- AKOS BAR-0057;4-(3-Tolyl)benzaldehyde;4-(3-Methylphenyl)benzaldehyde;3'-METHYLBIPHENYL-4-CARBALDEHYDE;4-Formyl-3'-methyl-1,1'-biphenyl;3'-METHYL-BIPHENYL-4-CARBOXALDEHYDE;3'-methylbiphenyl-4-carbaldehyde (95 %);3'-METHYL[1,1'-BIPHENYL]-4-CARBALDEHYDE;3'-Methyl-[1,1'-biphenyl]-4-carbaldehyde;3'-METHYL [1,1'-BIPHENYL]-4-CARBOXALDEHYDE
- CBNumber:
- CB2453369
- Molecular Formula:
- C14H12O
- Molecular Weight:
- 196.24
- MDL Number:
- MFCD03424618
- MOL File:
- 400744-83-4.mol
- MSDS File:
- SDS
| Melting point | 45-49℃ |
|---|---|
| Boiling point | 332.9±21.0 °C(Predicted) |
| Density | 1.074±0.06 g/cm3(Predicted) |
| Flash point | >110°(230°F) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| Appearance | Light yellow to brown Solid |
| Sensitive | Air Sensitive |
| CAS DataBase Reference | 400744-83-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2912290090 | |||||||||
| NFPA 704 |
|
4-(3-Methylphenyl)benzaldehyde price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 283202 | 3'-Methyl-[1,1'-biphenyl]-4-carbaldehyde Asreported | 400744-83-4 | 100mg | $319 | 2026-06-03 | Buy |
| Usbiological | 283202 | 3'-Methyl-[1,1'-biphenyl]-4-carbaldehyde Asreported | 400744-83-4 | 250mg | $432 | 2026-06-03 | Buy |
| Usbiological | 283202 | 3'-Methyl-[1,1'-biphenyl]-4-carbaldehyde Asreported | 400744-83-4 | 500mg | $559 | 2026-06-03 | Buy |
| Usbiological | 283202 | 3'-Methyl-[1,1'-biphenyl]-4-carbaldehyde Asreported | 400744-83-4 | 1g | $715 | 2026-06-03 | Buy |
| Apolloscientific | OR7510 | 3'-Methyl-[1,1'-biphenyl]-4-carboxaldehyde 95% | 400744-83-4 | 250mg | $22 | 2026-06-04 | Buy |
4-(3-Methylphenyl)benzaldehyde Chemical Properties,Uses,Production
Uses
4-Formyl-3''-methyl-1,1''-biphenyl acts as a reagent in the preparation of cyclodextrin-supported palladium complex that efficiently catalysis Suzuki-Miyaura cross coupling reactions.
Synthesis
17933-03-8
87199-17-5
400744-83-4
General procedure for the synthesis of 3'-methyl-[1,1'-biphenyl]-4-carbaldehyde from 3-methylphenylboronic acid and 4-formylphenylboronic acid: arylboronic acid (0.5 mmol) and K2CO3 (1 mmol, 138.0 mg) were added to a 20 mL Schlenk tube fitted with a non-magnetic stir bar. The tube was evacuated twice and backfilled with N2. MeCN (2 mL) and I2 (0.75 mmol, 191 mg) were added to the tube at room temperature. The tube was sealed and placed in a preheated oil bath at 80 °C for 8-12 h under a stream of N2 gas for the reaction. After the reaction mixture was cooled to room temperature, acrylic boronic acid (0.75 mmol) and Pd(OAc)2 (0.025 mmol, 5.6 mg) were added and the mixture was stirred at 80 °C for 12-16 hours. After completion of the reaction, the mixture was cooled to room temperature and quenched by the addition of H2O (10 mL). The aqueous layer was extracted with EtOAc (3 x 5 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated by rotary evaporation. The residue was purified by silica gel column chromatography to afford the target product 3'-methyl-[1,1'-biphenyl]-4-carbaldehyde. Experimental data are provided for three representative examples.
References
[1] Synlett, 2014, vol. 25, # 7, p. 995 - 1000
4-(3-Methylphenyl)benzaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Nanjing YakeLun Pharmaceutical Co., Ltd. | 025-66096098 3165145969 | sales@accoronpharm.com | China | 3924 | 55 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6736 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
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