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TRIMETHYLSILYL ISOTHIOCYANATE

TRIMETHYLSILYL ISOTHIOCYANATE Structure
TRIMETHYLSILYL ISOTHIOCYANATE structure
CAS No.
2290-65-5
Chemical Name:
TRIMETHYLSILYL ISOTHIOCYANATE
Synonyms
ISOTHIOCYANATOTRIMETHYLSILANE;Trimethylsilyl Isothicyanate;TRIMETHYLSILYL ISOTHIOCYANATE;isothiocyanatotrimethyl-silan;Trimethylsilylisothiocyanate,94%;Silane, isothiocyanatotrimethyl-;Trimethylsilyl isothiocyanate,97%;(TriMethylsilyl)isothiocyanate 99%
CBNumber:
CB2460765
Molecular Formula:
C4H9NSSi
Molecular Weight:
131.27
MDL Number:
MFCD00004797
MOL File:
2290-65-5.mol
Last updated:2026-01-13 11:16:47
Product description Number Pack Size Price
Trimethylsilyl isothiocyanate 99% 230766 10g $265
Trimethylsilyl isothiocyanate 99% 230766 50g $444
Trimethylsilyl isothiocyanate 95% 153248 10g $222
Trimethylsilyl isothiocyanate 2417BA 10g $349
Trimethylsilyl isothiocyanate 95% 153248 25g $370
More product size
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TRIMETHYLSILYL ISOTHIOCYANATE Properties

Melting point −32.8 °C(lit.)
Boiling point 143 °C(lit.)
Density 0.931 g/mL at 25 °C(lit.)
vapor density >1 (vs air)
refractive index n20/D 1.482(lit.)
Flash point 95 °F
storage temp. 2-8°C
form liquid
Specific Gravity 0.931
Water Solubility Reacts with water.
Sensitive Moisture Sensitive
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
BRN 1745262
InChI 1S/C4H9NSSi/c1-7(2,3)5-4-6/h1-3H3
InChIKey XLTUPERVRFLGLJ-UHFFFAOYSA-N
SMILES C[Si](C)(C)N=C=S
CAS DataBase Reference 2290-65-5(CAS DataBase Reference)
FDA UNII JK38S9F7MN
EPA Substance Registry System Isothiocyanatotrimethylsilane (2290-65-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H226-H301+H311+H331-H315-H319-H334-H335
Precautionary statements  P210-P280-P301+P310-P303+P361+P353-P304+P340+P311-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  T
Risk Statements  10-23/24/25-36/37/38-42
Safety Statements  23-26-36/37-45
RIDADR  UN 1992 3/PG 3
WGK Germany  3
F  10-19-21
TSCA  TSCA listed
HazardClass  3
PackingGroup  II
HS Code  29319090
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Flam. Liq. 3
Resp. Sens. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
2
3 0

TRIMETHYLSILYL ISOTHIOCYANATE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 230766 Trimethylsilyl isothiocyanate 99% 2290-65-5 10g $265 2025-07-31 Buy
Sigma-Aldrich 230766 Trimethylsilyl isothiocyanate 99% 2290-65-5 50g $444 2025-07-31 Buy
Matrix Scientific 153248 Trimethylsilyl isothiocyanate 95% 2290-65-5 10g $222 2021-12-16 Buy
AK Scientific 2417BA Trimethylsilyl isothiocyanate 2290-65-5 10g $349 2021-12-16 Buy
Matrix Scientific 153248 Trimethylsilyl isothiocyanate 95% 2290-65-5 25g $370 2021-12-16 Buy
Product number Packaging Price Buy
230766 10g $265 Buy
230766 50g $444 Buy
153248 10g $222 Buy
2417BA 10g $349 Buy
153248 25g $370 Buy

TRIMETHYLSILYL ISOTHIOCYANATE Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

Trimethylsilyl isothiocyanate is used as derivatizing reagent during the synthesis of amino acid thiohydantoins. It participates in ring opening reaction of N-substituted aziridines and cyclohexene oxide.

Uses

Trimethylsilyl isothiocyanate was used as derivatizing reagent during the synthesis of amino acid thiohydantoins.

General Description

Trimethylsilyl isothiocyanate (TMS-ITC) reacts with fullerene-mixed peroxide C60(O)(OOtBu)4 to yield isothiocyanate derivative C60(NCS)(OH)(OOtBu)4. TMS-ITC undergoes condensation with ethyl 2-benzylamino-5-methyl-3-phenylcyclopent-1-enecarboxylate to yield 1-benzyl-5-methyl-7-phenyl-2-thioxo-1,2,3,5,6,7-hexahydrocyclopentapyrimidin-4-one. It participates in ring opening reaction of N-substituted aziridines and cyclohexene oxide.

Purification Methods

The 1H NMR spectrum should have only one peak; if not purify it by repeated fractionation in an all-glass system using a 50cm (4mm internal diameter) column without packing. [Anderson J Am Chem Soc 69 3049 1947, Fehér & Blümcke Chem Ber 90 1934 1957, Neidleim & Hege Synthesis 51 1975, Beilstein 4 III 1861, 4 IV 4011.]

TRIMETHYLSILYL ISOTHIOCYANATE synthesis

18306-29-1
333-20-0
2290-65-5
Synthesis of TRIMETHYLSILYL ISOTHIOCYANATE from Bis(trimethylsilyl)sulfate and Potassium thiocyanate

TRIMETHYLSILYL ISOTHIOCYANATE Preparation Products And Raw materials

Raw materials

Bis(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)disulfide trimethylsilyl isocyanide Bis(trimethylsilyl)sulfate Trimethylsilyl cyanide Potassium thiocyanate
Chlorotrimethylsilane

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Preparation Products

2-Amino-5-methyl-1,3,4-thiadiazole 1-ADAMANTYL ISOTHIOCYANATE PF-06282999 Trimethylsilyl Isocyanate ETHYL ISOTHIOCYANATOACETATE
TRIMETHYLSILYL TRIFLUOROACETATE Hexamethyldisiloxane

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TRIMETHYLSILYL ISOTHIOCYANATE Suppliers

Global( 69)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13799 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Alfa Chemistry 		+1-5166625404; Info@alfa-chemistry.com United States 20405 58
Shaanxi Didu New Materials Co. Ltd 		+86-89586680 +86-13289823923 1026@dideu.com China 8317 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49964 58
R&D Scientific Inc. 		+1-2266000236 sales@rdscientific.com Canada 1929 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. 		+8618950047208 ellena@amitychem.com China 43416 58
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Alfa Chemistry 		58
Shaanxi Didu New Materials Co. Ltd 		58
PT CHEM GROUP LIMITED 		58
GIHI CHEMICALS CO.,LIMITED 		58
R&D Scientific Inc. 		58
Aladdin Scientific 		58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. 		58

View Lastest Price from TRIMETHYLSILYL ISOTHIOCYANATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trimethylsilyl isothiocyanate pictures 2025-06-26 Trimethylsilyl isothiocyanate
2290-65-5
 US $12080.00 / g 1g 99 % 500 Kg R&D Scientific Inc.
(Trimethylsilyl)isothiocyanate 99% pictures 2021-07-02 (Trimethylsilyl)isothiocyanate 99%
2290-65-5
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

TRIMETHYLSILYL ISOTHIOCYANATE Spectrum

TRIMETHYLSILYL ISOTHIOCYANATE(2290-65-5)FT-IRTRIMETHYLSILYL ISOTHIOCYANATE(2290-65-5)IR

2290-65-5(TRIMETHYLSILYL ISOTHIOCYANATE)Related Search:

5-Chloro-2-methyl-4-isothiazolin-3-one 4-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER Ethyl isonicotinate Benzyl isocyanate Ethoxycarbonyl Isothiocyanate
Benzyl thiocyanate Trimethoxy(pentamethylcyclopentadienyl) titanium(IV) 3-FLUOROPHENYL ISOCYANATE 4-Fluorophenyl isocyanate Ethyl isocyanoacetate
Isopropyl isothiocyanate 2-ETHOXYPHENYL ISOCYANATE Isobutyl isocyanate TRIMETHYLSILYL ISOCYANATE triethyl(3-isocyanatopropyl)silane
TRIMETHYLSILYL ISOTHIOCYANATE isothiocyanic acid TRIMETHYLSILYL BROMOACETATE

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isothiocyanatotrimethyl-silan Silane, isothiocyanatotrimethyl- TRIMETHYLSILYL ISOTHIOCYANATE ISOTHIOCYANATOTRIMETHYLSILANE Trimethylsilylisothiocyanate,94% Trimethylsilyl isothiocyanate,97% (TriMethylsilyl)isothiocyanate 99% Trimethylsilyl Isothicyanate 2290-65-5 C4H9NSSi CH33SiNCS Building Blocks Sulfur Compounds Thiocyanates/Isothiocyanates Organic Building Blocks