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1-NAPHTHOHYDROXAMIC ACID

1-NAPHTHOHYDROXAMIC ACID structure

CAS No.: 6953-61-3

Chemical Name:: 1-NAPHTHOHYDROXAMIC ACID

Synonyms: NSC 57457;Naphthohydroxamicacid;a-Naphthohydroxamic acid;1-NAPHTHOHYDROXAMIC ACID;1-NaphthohydroxamicAcid>alpha-naphthohydroxamicacid;1-NAPHTHOHYDROXAMIC ACID 98+%;HDAC Inhibitor XIX, Compound 2;n-hydroxy-1-naphthalenecarboxamid;1-Naphthalenecarbohydroximic acid

CBNumber:: CB2462406

Molecular Formula:: C11H9NO2

Molecular Weight:: 187.19

MDL Number:: MFCD00059546

MOL File:: 6953-61-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:33:53

Product description	Number	Pack Size	Price
HDAC Inhibitor XIX, Compound 2	382177	50mg	$110
1-Naphthohydroxamic Acid >98.0%(T)	N0023	1g	$338
N-Hydroxy-1-naphthamide	312235	250.00mg	$63
N-Hydroxy-1-naphthamide	312235	1.00g	$173
N-Hydroxy-1-naphthamide	312235	5.00g	$541

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1-NAPHTHOHYDROXAMIC ACID Properties

Melting point	176-178 °C
Density	1.291±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥5mg/mL
pka	8.91±0.30(Predicted)
form	White solid
color	white to tan
InChI	1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)
InChIKey	JRZGPWOEHDOVMC-UHFFFAOYSA-N
SMILES	ONC(=O)c1cccc2ccccc12
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H312-H302-H332
Precautionary statements	P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312
Risk Statements	52
WGK Germany	3
RTECS	QJ1894500
HS Code	2928009090
Storage Class	11 - Combustible Solids

1-NAPHTHOHYDROXAMIC ACID price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	382177	HDAC Inhibitor XIX, Compound 2	6953-61-3	50mg	$110	2023-01-07	Buy
TCI Chemical	N0023	1-Naphthohydroxamic Acid >98.0%(T)	6953-61-3	1g	$338	2026-04-30	Buy
Matrix Scientific	312235	N-Hydroxy-1-naphthamide	6953-61-3	250.00mg	$63	2026-05-19	Buy
Matrix Scientific	312235	N-Hydroxy-1-naphthamide	6953-61-3	1.00g	$173	2026-05-19	Buy
Matrix Scientific	312235	N-Hydroxy-1-naphthamide	6953-61-3	5.00g	$541	2026-05-19	Buy

Product number	Packaging	Price	Buy
382177	50mg	$110	Buy
N0023	1g	$338	Buy
312235	250.00mg	$63	Buy
312235	1.00g	$173	Buy
312235	5.00g	$541	Buy

1-NAPHTHOHYDROXAMIC ACID Chemical Properties,Uses,Production

Uses

1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.

Biochem/physiol Actions

1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.

in vivo

Dose-limiting toxicities (DLTs) of 1-Naphthohydroxamic acid (compound 2; 0-40 mg/kg; intraperitoneal injection; daily; for 10 day; NMRI Foxn1 nude mice) include weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. 1-Naphthohydroxamic acid has the maximum tolerable doses at 50mg/kg per day. At these concentrations, neither body weight nor blood parameters are critically changed^[3].
Pharmacokinetic studies after intraperitoneal administration of the inhibitors identified the half-life of 1-Naphthohydroxamic acid to be ~15min, with a plasma peak concentration of ~30μM^[3].

Animal Model:	NMRI Foxn1 nude mice^[3]
Dosage:	0 mg/kg, 50 mg/kg, 100mg/kg, 200 mg/kg, 300 mg/kg 400 mg/kg
Administration:	Intraperitoneal injection; daily; for 10 days
Result:	Dose-limiting toxicities (DLTs) included weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination.

IC 50

HDAC8: 14 μM (IC₅₀); HDAC1: >100 μM (IC₅₀); HDAC6: >100 μM (IC₅₀)

1-NAPHTHOHYDROXAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

1-NAPHTHOHYDROXAMIC ACID Suppliers

Global( 85)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30225	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49968	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40228	62

Supplier	Advantage
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62

View Lastest Price from 1-NAPHTHOHYDROXAMIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	1-Naphthohydroxamic acid 6953-61-3	$29.00-116.00		99.19%	10g	TargetMol Chemicals Inc.
	2026-05-11	1-Naphthohydroxamic acid 6953-61-3	$29.00-116.00		99.19%	10g	TargetMol Chemicals Inc.

1-Naphthohydroxamic acid
6953-61-3
$29.00-116.00
99.19%
TargetMol Chemicals Inc.

1-Naphthohydroxamic acid
6953-61-3
$29.00-116.00
99.19%
TargetMol Chemicals Inc.

1-NAPHTHOHYDROXAMIC ACID Spectrum

1-NAPHTHOHYDROXAMIC ACID(6953-61-3)MS 1-NAPHTHOHYDROXAMIC ACID(6953-61-3)¹HNMR 1-NAPHTHOHYDROXAMIC ACID(6953-61-3)¹³CNMR 1-NAPHTHOHYDROXAMIC ACID(6953-61-3)IR1

6953-61-3(1-NAPHTHOHYDROXAMIC ACID)Related Search:

Pyrazine 2-Naphthohydroxamic acid, O-acetate ester Naftalofos N-HYDROXYNAPHTHALIMIDE SODIUM SALT N-Hydroxy-1,8-naphthalimide

Naphthaloximidodiethyl thiophosphate N-Hydroxynaphthalimide triflate 1-NAPHTHOHYDROXAMIC ACID

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HDAC Inhibitor XIX, Compound 2 - CAS 6953-61-3 - Calbiochem Naphthalene-1-carbohydroximic acid N-Hydroxy-1-naphthalenecarboxamide a-Naphthohydroxamic acid NSC 57457 HDAC Inhibitor XIX, Compound 2 N-HYDROXYNAPHTHALENE-1-CARBOXAMIDE alpha-naphthohydroxamicacid n-hydroxy-1-naphthalenecarboxamid 1-NAPHTHOHYDROXAMIC ACID Naphthohydroxamicacid 1-NAPHTHOHYDROXAMIC ACID 98+% 1-Naphthalenecarbohydroximic acid 1-NaphthohydroxamicAcid> tubulin,anti-proliferation,deacetylate,HDAC8,Inhibitor,1 Naphthohydroxamic acid,hyperacetylated,1Naphthohydroxamic acid,acetylation,inhibit,clone,HDAC,Histone deacetylases,1-Naphthohydroxamic acid 1-Naphthalenecarboxamide, N-hydroxy- 1-Naphthohydroxamic acid, HDAC8 inhibitor 1-Naphthohydroxamic acid, 10 mM in DMSO 6953-61-3 Hydroxylamines Hydroxylamines (N-Substituted) Hydroxylamines Hydroxylamines (N-Substituted)