Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Dersimelagon

Dersimelagon

Dersimelagon Structure
Dersimelagon structure
CAS No.
1835256-48-8
Chemical Name:
Dersimelagon
Synonyms
Dersimelagon;Dersimelagon, 10 mM in DMSO;1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid;4-Piperidinecarboxylic acid, 1-[2-[(3S,4R)-1-[[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)-3-pyrrolidinyl]carbonyl]-4-(methoxymethyl)-3-pyrrolidinyl]-5-(trifluoromethyl)phenyl]-
CBNumber:
CB24667818
Molecular Formula:
C36H45F4N3O5
Molecular Weight:
675.75
MDL Number:
MOL File:
1835256-48-8.mol
Last updated:2025-09-30 18:11:34
Request For Quotation

Dersimelagon Properties

Boiling point 758.1±60.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
solubility DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml
form Solid
pka 6.88±0.60(Predicted)
color Off-white to light yellow
InChIKey MUNWOYRHJPWQNE-GMFUQMJFSA-N
SMILES N1(C2=CC(C(F)(F)F)=CC=C2[C@@H]2[C@@H](COC)CN(C([C@@]3(F)[C@H](C4=CC=C(OC)C=C4)CN(C4CCCC4)C3)=O)C2)CCC(C(O)=O)CC1
FDA UNII 1CWH5SV4G2
NCI Drug Dictionary dersimelagon

Dersimelagon Chemical Properties,Uses,Production

Uses

Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation[1][2].

in vivo

Dersimelagon (0.003, 0.03, 0.3, 3 mg/kg; p.o. for 6 days) induces coat colour darkening in Ay/a mice in 0.3 and 3 mg/kg[1].
Dersimelagon (0.03, 0.3, 3 mg/kg; p.o.; single administration) upregulates the expression of Tyr, Trp1 and Dct of Ay/a mice at 24, 48 and 72 h in the 3 mg/kg[1].
Dersimelagon (1, 3, 10 mg/kg for 4 weeks and 30 mg/kg for 3 weeks; p.o.) induces pigmentation in a dose-dependent manner, and it is reverses after cessation of administration in cynomolgus monkeys[1].

Animal Model:Cynomolgus monkeys[1]
Dosage:1, 3, 10, 30 mg/kg
Administration:P.o.; 1, 3, 10 mg/kg for 4 weeks and 30 mg/kg for 3 weeks
Result:Induced pigmentation in a dose-dependent manner.
Minimum pigmentation effective dose was 1 mg/kg.
Pigmentation diminished 4 weeks after cessation of treatment in the 1, 3 and 10 mg/kg groups and 16 weeks after cessation in the 30 mg/kg group.

IC 50

hMC1R: 2.26 nM (Ki); hMC4R: 32.9 nM (Ki); hMC5R: 486 nM (Ki); hMC3R: 1420 nM (Ki); hMC1R: 8.16 nM (EC50); hMC4R: 79.6 nM (EC50); hMC2R: >10000 nM (EC50); rMC1R: 0.251 nM (EC50); mMC1R: 1.14 nM (EC50); cmMC1R: 3.91 nM (EC50)

References

[1] T. Suzuki, et al. Melanogenic effect of dersimelagon (MT-7117), a novel oral melanocortin 1 receptor agonist. Skin Health Dis. 2022; 2(1):e78.
[2] Erwin AL, et al. Porphyrias in the Age of Targeted Therapies. Diagnostics (Basel). 2021;11(10):1795. Published 2021 Sep 29. DOI:10.3390/diagnostics11101795
[3] MASAHIRO KONDO. Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis.[J]. Arthritis Research & Therapy, 2022: 210. DOI: 10.1186/s13075-022-02899-3

Dersimelagon Preparation Products And Raw materials

Raw materials

Preparation Products

Dersimelagon Suppliers

Global( 27)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 024-024-024-88590548 18341751992 757984502@qq.com China 941 58
Bide Pharmatech Ltd. 400-164-7117 13681763483 product02@bidepharm.com China 42446 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4669 55
Shanghai Han-Xiang Chemical Co., Ltd. 15971444841 amber@biochempartner.com China 3061 58
Guangzhou Younan Technology Co., Ltd 020-82000279 18988968278 YN_research@163.com China 3003 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 997 58
Supplier Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
Bide Pharmatech Ltd. 60
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Han-Xiang Chemical Co., Ltd. 58
Guangzhou Younan Technology Co., Ltd 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58

View Lastest Price from Dersimelagon manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dersimelagon pictures 2025-09-30 Dersimelagon
1835256-48-8
 US $72.00-278.00 / mg 98.23% 10g TargetMol Chemicals Inc.
Dersimelagon pictures 2024-01-25 Dersimelagon
1835256-48-8
 US $1900.00 / g 0.1g 98+ 100g Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
  • Dersimelagon pictures
  • Dersimelagon
    1835256-48-8
  • US $72.00-278.00 / mg
  • 98.23%
  • TargetMol Chemicals Inc.
  • Dersimelagon pictures
  • Dersimelagon
    1835256-48-8
  • US $1900.00 / g
  • 98+
  • Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Dersimelagon Spectrum

Dersimelagon(1835256-48-8)1HNMR
Dersimelagon 4-Piperidinecarboxylic acid, 1-[2-[(3S,4R)-1-[[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)-3-pyrrolidinyl]carbonyl]-4-(methoxymethyl)-3-pyrrolidinyl]-5-(trifluoromethyl)phenyl]- 1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid Dersimelagon, 10 mM in DMSO 1835256-48-8