ChemicalBook >> CAS DataBase List >>2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
- CAS No.
- 4442-53-9
- Chemical Name:
- 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
- Synonyms
- 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid;4-(2;2,3-DIHYDRO-BENZO[1,4]DIOXINE-5-CARBOXYLIC ACID;3-Dihydro-1;AKOS BBS-00002750;2,3-Dihydro-1,4-benz;5-CARBOXY-1,4-BENZODIOXANE;Compound 3344 hydrochloride;2,3-Ethylenedioxybenzoic Acid;4-benzodioxine-5-carboxylic acid
- CBNumber:
- CB2467643
- Molecular Formula:
- C9H8O4
- Molecular Weight:
- 180.16
- MDL Number:
- MFCD00239415
- MOL File:
- 4442-53-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-27 17:00:41
| Melting point | 90-94 °C(lit.) |
|---|---|
| Boiling point | 334.1±41.0 °C(Predicted) |
| Density | 1.376±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.09±0.20(Predicted) |
| form | powder to crystal |
| color | Light yellow to Brown |
| InChI | 1S/C9H8O4/c10-9(11)6-2-1-3-7-8(6)13-5-4-12-7/h1-3H,4-5H2,(H,10,11) |
| InChIKey | VCLSWKVAHAJSFL-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cccc2OCCOc12 |
| CAS DataBase Reference | 4442-53-9(CAS DataBase Reference) |
| FDA UNII | 1MM53EOJ8A |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39-36/37/38 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29329900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 563331 | 1,4-Benzodioxan-5-carboxylic acid 98% | 4442-53-9 | 5g | $69.2 | 2023-06-20 | Buy |
| TCI Chemical | B3864 | 1,4-Benzodioxane-5-carboxylic Acid >98.0%(GC)(T) | 4442-53-9 | 5g | $51 | 2026-04-30 | Buy |
| TCI Chemical | B3864 | 1,4-Benzodioxane-5-carboxylic Acid >98.0%(GC)(T) | 4442-53-9 | 25g | $200 | 2026-04-30 | Buy |
| Apolloscientific | OR23013 | 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid ≥95% | 4442-53-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR23013 | 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid ≥95% | 4442-53-9 | 10g | $24 | 2026-06-04 | Buy |
2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Synthesis
29668-43-7
4442-53-9
The general procedure for the synthesis of 2,3-dihydro-1,4-benzodioxane-5-carboxylic acid from 2,3-dihydrobenzo[b][1,4]dioxane-5-carboxaldehyde was as follows: 2,3-dihydrobenzo[b][1,4]dioxane-5-carboxaldehyde (0.500 g, 3.04 mmol) was dissolved in acetone (10 mL) and mixed with an aqueous solution of sulfamic acid at 0-5 °C ( 0.455 g, 4.5 mmol) was mixed and stirred. After the reaction mixture was stirred for 20 minutes, aqueous sodium chlorite (0.421 g, 4.5 mmol) was added and the reaction was continued for 18 hours at room temperature. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and quenched with water. The resulting solid was collected by filtration and dried under vacuum to afford the target product 2,3-dihydro-1,4-benzodioxane-5-carboxylic acid (0.332 g). The product was characterized as follows: 1H NMR (DMSO-d6): δ 4.27 (s, 4H), 6.84 (t, J = 7.2 Hz, 1H), 7.02 (d, J = 7.8 Hz, 1H), 7.20 (d, J = 7.5 Hz, 1H), 12.5 (bs, 1H); MS [M + H]+: 181.12.
References
[1] Patent: WO2013/153535, 2013, A1. Location in patent: Page/Page column 63
2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 205)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Lastest Price from 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-08 | Compound 3344 hydrochloride | $88.00-269.00 | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
4442-53-9
|
$1.00 | 1kg | 95%-99% | Career Henan Chemical Co |
-
- Compound 3344 hydrochloride
- $88.00-269.00
- 99.89%
- TargetMol Chemicals Inc.
-
- 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
4442-53-9
- $1.00
- 95%-99%
- Career Henan Chemical Co
4442-53-9(2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid)Related Search:
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2,3-dihydro-1,4-benzodioxin-5-carboxylic acid
1,4-Benzodioxine-5-carboxylicacid
2,3-DIHYDRO-1,4-BENZODIOXAN-5-CARBOXYLIC ACID,99%
2,3-Dihydro-1,4-benzodioxane-5-hydroxyacid
1,4-Benzodioxin-5-carboxylic acid, 2,3-dihydro-
2,3-Dihydro-1,4-benz
3-Dihydro-1
4-benzodioxine-5-carboxylic acid
1,4-Benzodioxan-5-carboxylic acid/2,3-Dihydro-1,4-Benzodioxine-5-Carboxylic Acid
1,4-Benzodioxan-5-carboxylic acid,98%
2,3-Ethylenedioxybenzoic Acid
2,3-dihydro-1,4-benzodioxane-5-carboxylic acid
5-Carboxy-2,3-dihydro-1,4-benzodioxine, 1,4-Benzodioxane-5-carboxylic acid
1,4-Benzodioxane-5-carboxylicAcid>
Compound 3344 hydrochloride
2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid
4-(2
4442-53-9
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