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4-Hydroxydiphenylamine

4-Hydroxydiphenylamine structure

CAS No.: 122-37-2

Chemical Name:: 4-Hydroxydiphenylamine

Synonyms: vti1;VTI2;VTI 1;VTI1L;VTI1L1;v-SNARE;vti1-rp1;VTI1-LIKE;4-ANILINOPHENOL;P-ANILINOPHENOL

CBNumber:: CB2470708

Molecular Formula:: C12H11NO

Molecular Weight:: 185.22

MDL Number:: MFCD00020142

MOL File:: 122-37-2.mol

MSDS File:: SDS

Last updated:2025-08-21 11:10:19

Product description	Number	Pack Size	Price
4-HYDROXYDIPHENYLAMINE Aldrich^CPR	S579025	1 unit	$185
4-HYDROXYDIPHENYLAMINE Aldrich	S579025	1g	$179
4-Hydroxydiphenylamine >98.0%(HPLC)(T)	A0470	25g	$67
4-Hydroxydiphenylamine >98.0%(HPLC)(T)	A0470	500g	$715
4-Hydroxydiphenylamine	H941750	10g	$55
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4-Hydroxydiphenylamine Properties

Melting point	67-73°C
Boiling point	190°C
Density	1.0936 (rough estimate)
refractive index	1.5300 (estimate)
Flash point	209°C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Ethanol: Soluble: =10 mg/mlPBS (pH 7.2): Soluble: =10 mg/ml
form	powder to lump
pka	10.46±0.13(Predicted)
color	Gray, solid leaflets
BRN	511942
InChI	InChI=1S/C12H11NO/c14-12-8-6-11(7-9-12)13-10-4-2-1-3-5-10/h1-9,13-14H
InChIKey	JTTMYKSFKOOQLP-UHFFFAOYSA-N
SMILES	C1(O)=CC=C(NC2=CC=CC=C2)C=C1
CAS DataBase Reference	122-37-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	AYK489T98N
NIST Chemistry Reference	Phenol, 4-(phenylamino)-(122-37-2)
EPA Substance Registry System	Phenol, 4-(phenylamino)- (122-37-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS05

Signal word

Warning

Hazard statements

H303-H318-H315-H319

Precautionary statements

P280i-P305+P351+P338-P310a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

37/38-41-22-21

Safety Statements

26-36/37/39-36/39

RIDADR

UN2811

RTECS

SJ6950000

TSCA

Yes

HazardClass

6.1

PackingGroup

III

HS Code

29222990

Toxicity

LD50 oral in rat: 3300mg/kg

NFPA 704

	0
2		0

4-Hydroxydiphenylamine price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S579025	4-HYDROXYDIPHENYLAMINE Aldrich^CPR	122-37-2	1 unit	$185	2025-07-31	Buy
Sigma-Aldrich	S579025	4-HYDROXYDIPHENYLAMINE Aldrich	122-37-2	1g	$179	2024-03-01	Buy
TCI Chemical	A0470	4-Hydroxydiphenylamine >98.0%(HPLC)(T)	122-37-2	25g	$67	2025-07-31	Buy
TCI Chemical	A0470	4-Hydroxydiphenylamine >98.0%(HPLC)(T)	122-37-2	500g	$715	2025-07-31	Buy
TRC	H941750	4-Hydroxydiphenylamine	122-37-2	10g	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
S579025	1 unit	$185	Buy
S579025	1g	$179	Buy
A0470	25g	$67	Buy
A0470	500g	$715	Buy
H941750	10g	$55	Buy

4-Hydroxydiphenylamine Chemical Properties,Uses,Production

Uses

4-Hydroxydiphenylamine is used as a reactant in the preparation of iron methylisopropylglyoxime dimethylpyridine/dimethylaminopyridine/phenylaminophenol/imidazolidone complexes.

Definition

Gray solid leaflets. Insoluble in water; soluble in alcohol, ether, acetone, chloroform, alkali, and benzene.

Hazard

Irritant.

Safety Profile

Poison by intravenous route.Moderately toxic by ingestion. A severe eye irritant. Seealso AROMATIC AMINES. When heated todecomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the amine from chlorobenzene/pet ether, pentane (m 72o) or *C6H6/pet ether (m 70o). [Beilstein 13 III 1019, 13 IV 1052.]

References

[1] HAOQI NINA ZHAO, EDWARD P. KOLODZIEJ* Transformation Products of Tire Rubber Antioxidant 6PPD in Heterogeneous Gas-Phase Ozonation: Identification and Environmental Occurrence[J]. 环境科学与技术, 2023, 57 14: 5621-5632. DOI: 10.1021/acs.est.2c08690
[2] NICO GRASSE, THORSTEN REEMTSMA* Uptake and Biotransformation of the Tire Rubber-derived Contaminants 6-PPD and 6-PPD Quinone in the Zebrafish Embryo (Danio rerio)[J]. 环境科学与技术, 2023, 57 41: 15598-15607. DOI: 10.1021/acs.est.3c02819
[3] W E ALEXANDER S E W A J Ryan. Metabolism of diphenylamine in the rat, rabbit and man.[J]. Food and cosmetics toxicology, 1965, 3 4: 571-579. DOI: 10.1016/s0015-6264(65)80203-6
[4] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

4-Hydroxydiphenylamine Preparation Products And Raw materials

Raw materials

4-Phenoxyaniline Iodobenzene 4-Aminophenol

Preparation Products

Sulphur Brown 96 Phenol, 4-(phenylamino)-, sulfurized, leuco deriv. C.I. Leuco Sulfur Red 10 Sulphur Red 10 Acetic acid 4-(acetyl-phenyl-amino)-phenyl ester

4-Hydroxydiphenylamine Suppliers

Global( 252)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Hubei Jusheng Technology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Shenzhen Excellent Biotech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 4-Hydroxydiphenylamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-25	4-Hydroxydiphenylamine 122-37-2	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-05-26	4-Hydroxydiphenylamine 122-37-2	US $9.00 / KG	1KG	99.9	1 ton	Hebei Chuanghai Biotechnology Co,.LTD
2019-07-06	4-Hydroxydiphenylamine 122-37-2	US $1.00 / kg	1kg	99%	Customized	Career Henan Chemical Co

4-Hydroxydiphenylamine
122-37-2
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

4-Hydroxydiphenylamine
122-37-2
US $9.00 / KG
99.9
Hebei Chuanghai Biotechnology Co,.LTD

4-Hydroxydiphenylamine
122-37-2
US $1.00 / kg
99%
Career Henan Chemical Co

4-Hydroxydiphenylamine Spectrum

4-Hydroxydiphenylamine(122-37-2)MS 4-Hydroxydiphenylamine(122-37-2)¹HNMR 4-Hydroxydiphenylamine(122-37-2)¹³CNMR 4-Hydroxydiphenylamine(122-37-2)IR1 4-Hydroxydiphenylamine(122-37-2)IR2 4-Hydroxydiphenylamine(122-37-2)IR3

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4-(phenylamino)-pheno P-HYDROXYDIPHENYLAMINE P-ANILINOPHENOL 4-ANILINOPHENOL 4-ANILINO-1-HYDROXYBENZENE 4-(N-PHENYLAMINO)PHENOL 4-(phenylamino)-phenol 4-HYDROXYDIPHENYLAMINE vti1 4-HYDROXYDIPHENYLAMINE 95+% 4-ANILINO-1-HYDROXYBENZENE 98% 4-Hydroxyphenylphenylamine 4-Oxydiphenylamine Para-hydroxydiphenylamine 4-Hydroxy-1,1'-diphenylamine PARA-ANILINOPHENOL 4-hydroxy-diphenylamin Diphenylamine, 4-hydroxy- N-Phenyl-p-aminophenol p-(Phenylamino)phenol p-anilino-pheno para-Hydroxydifenylamin Phenol, p-anilino- Phenol,4-(phenylamino)- Phenyl-p-aminophenol p-Hydroxydifenylamin p-Oxydiphenylamine VTI 1 4-Hydroxydiphenylamine > 4-Hydroxydiphenylamine ISO 9001：2015 REACH 4-HYDROXY DIPHENYLAMINE (PEDIA) 4-Hydroxydiphenylamine, ≥ 95.0% v-SNARE VTI1L VTI1L1 VTI1-LIKE vti1-rp1 VTI2 122-37-2 AMINE Anilines, Aromatic Amines and Nitro Compounds ADVANCED INT.