RAGE antagonist peptide
- CAS No.
- 1092460-91-7
- Chemical Name:
- RAGE antagonist peptide
- Synonyms
- RAGE antagonist;RAGE antagonist peptide;RAGE antagonist peptide TFA;L-Leucinamide, N-acetyl-L-α-glutamyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-methionyl-L-α-glutamyl-L-lysyl-L-α-glutamyl-;(4S,7S,10S,13S,16S,19S,22S,25S,28S)-28-Acetamido-4-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)carbamoyl)-7,22-bis(4-aminobutyl)-10-(2-carboxyethyl)-16,25-diisobutyl-19-isopropyl-13-(2-(methylthio)ethyl)-6,9,12,15,18,21,24,27-octaoxo-5,8,11,14,17,20,23,26-octaazahentriacontanedioic acid
- CBNumber:
- CB24796602
- Molecular Formula:
- C57H101N13O17S
- Molecular Weight:
- 1272.57
- MDL Number:
- MFCD30742957
- MOL File:
- 1092460-91-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 1608.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 4.43±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| Water Solubility | Soluble to 1 mg/ml in water |
| Sequence | Ac-Glu-Leu-Lys-Val-Leu-Met-Glu-Lys-Glu-Leu-NH2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
RAGE antagonist peptide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | STB46091 | RAGE antagonist peptide | 1092460-91-7 | 10mg | $1075.9 | 2026-06-05 | Buy |
| Biosynth | STB46091 | RAGE antagonist peptide | 1092460-91-7 | 25mg | $1754 | 2026-06-05 | Buy |
| Biosynth | STB46091 | RAGE antagonist peptide | 1092460-91-7 | 50mg | $2807 | 2026-06-05 | Buy |
| Biosynth | CRB1001194 | RAGE antagonist peptide | 0.5mg | $165.73 | 2026-06-04 | Buy | |
| Biosynth | CRB1001194 | RAGE antagonist peptide | 1mg | $226.78 | 2026-06-04 | Buy |
RAGE antagonist peptide Chemical Properties, Uses, Production
Uses
RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities[1][2].
in vivo
RAGE antagonist peptide (RAP, 100 μg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo[1].
RAGE antagonist peptide (RAP) reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth[1].
In mice bearing asthma, RAGE antagonist peptide (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide also reduces total, cytoplasmic and nuclear levels of β-catenin, enhanced β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function[2].
| Animal Model: | Cancer cells expressing the NFκB-luc reporter implanted into immune-deficient mice[1]. |
| Dosage: | 100 μg. |
| Administration: | Intratumoral delivery (or intraperitoneally). |
| Result: | Systemic administration caused a substantial reduction (p<0.05) in the NFκB signal 5 h after injection. |
storage
Store at -20°C
References
[1] Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18(16):4356-64. DOI:10.1158/1078-0432.CCR-12-0221
[2] Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173(17):2600-13. DOI:10.1111/bph.13539
RAGE antagonist peptide Preparation Products And Raw materials
Raw materials
Preparation Products
RAGE antagonist peptide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4726 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Sichuan Jisheng Biopharmaceutical Co.,Ltd. | +86-0833-2598983 +86-18086877136 | Nyx-peptide@jsjpharm.cn | China | 287 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14072 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 17357109671 | sales3@gotopbio.com | China | 2988 | 58 |
