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CHMFL-ABL-053 (ABL-053)

CHMFL-ABL-053 (ABL-053) structure

CAS No.: 1808287-83-3

Chemical Name:: CHMFL-ABL-053 (ABL-053)

Synonyms: ABL-053;CHMFL-ABL-053 (ABL-053);2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, 2-[(3-amino-4-methylphenyl)amino]-4-(methylamino)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-

CBNumber:: CB24844642

Molecular Formula:: C28H26F3N7O2

Molecular Weight:: 549.55

MDL Number:

MOL File:: 1808287-83-3.mol

Last updated:2025-07-18 16:11:23

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CHMFL-ABL-053 (ABL-053) Properties

Density	1.418±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Powder
pka	11.09±0.70(Predicted)

CHMFL-ABL-053 (ABL-053) Chemical Properties,Uses,Production

Uses

CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively[1].

in vivo

CHMFL-ABL-053 (Compound 18a) (50 mg/kg/day) almost completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model^[1].

IC 50

p38: 62 nM (IC₅₀); Abl: 70 nM (IC₅₀); SRC: 90 nM (IC₅₀)

References

[1] Liang X, et al. Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia. J Med Chem. 2016 Mar 10;59(5):1984-2004. DOI:10.1021/acs.jmedchem.5b01618

CHMFL-ABL-053 (ABL-053) Preparation Products And Raw materials

Raw materials

Preparation Products

CHMFL-ABL-053 (ABL-053) Suppliers

Global( 6)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19939	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	12952	65
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	26070	58
ApexBio Technology	--	sales@apexbt.com	United States	6251	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12000	58

Supplier	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
TargetMol Chemicals Inc.	58
BOC Sciences	65
TargetMol Chemicals Inc.	58
ApexBio Technology	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

View Lastest Price from CHMFL-ABL-053 (ABL-053) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-07-18	CHMFL-ABL-053 1808287-83-3	US $2500.00-1980.00 / mg			10g	TargetMol Chemicals Inc.

CHMFL-ABL-053
1808287-83-3
US $2500.00-1980.00 / mg
TargetMol Chemicals Inc.

CHMFL-ABL-053 (ABL-053) ABL-053 5-Pyrimidinecarboxamide, 2-[(3-amino-4-methylphenyl)amino]-4-(methylamino)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]- 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide 1808287-83-3 C28H26F3N7O2