(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
- CAS No.
- 1346133-11-6
- Chemical Name:
- (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
- Synonyms
- FP3FBZ;LY2444296;Ly2444296 (fp3fbz);LY2444296, 10 mM in DMSO;(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide;3-fluoro-4-(4-{[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]methyl}phenoxy)benzamide;Benzamide, 3-fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)-1-pyrrolidinyl]methyl]phenoxy]-
- CBNumber:
- CB24858724
- Molecular Formula:
- C24H22F2N2O2
- Molecular Weight:
- 408.44
- MDL Number:
- MFCD32067413
- MOL File:
- 1346133-11-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| LY2444296 ≥98% (HPLC) | SML2452 | 5mg | $95.7 |
| LY2444296 ≥98% (HPLC) | SML2452 | 25mg | $386 |
| Ly2444296 (fp3fbz) | WDC13311 | 50mg | $1034.5 |
| Ly2444296 (fp3fbz) | WDC13311 | 100mg | $1440 |
| LY2444296 99.26% | CS-0110108 | 5mg | $87 |
| Boiling point | 491.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.276±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Ethanol: 27.5 mg/mL (67.33 mM); Methanol: 5 mg/mL (12.24 mM) |
| pka | 15.61±0.50(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| InChIKey | WHHMECUDUQRPJT-QFIPXVFZSA-N |
| SMILES | NC(C1=CC=C(OC2=CC=C(CN3CCC[C@H]3C4=CC=CC(F)=C4)C=C2)C(F)=C1)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2452 | LY2444296 ≥98% (HPLC) | 1346133-11-6 | 5mg | $95.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2452 | LY2444296 ≥98% (HPLC) | 1346133-11-6 | 25mg | $386 | 2026-04-30 | Buy |
| Biosynth | WDC13311 | Ly2444296 (fp3fbz) | 1346133-11-6 | 50mg | $1034.5 | 2026-06-05 | Buy |
| Biosynth | WDC13311 | Ly2444296 (fp3fbz) | 1346133-11-6 | 100mg | $1440 | 2026-06-05 | Buy |
| ChemScene | CS-0110108 | LY2444296 99.26% | 1346133-11-6 | 5mg | $87 | 2026-06-04 | Buy |
(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Chemical Properties,Uses,Production
Uses
LY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antagonist, with a Ki value of ～1 nM. LY2444296 exhibits anti-anxiety like effects[1][2].
Biological Activity
LY2444296 is a brain-penetrant, orally active, short-acting, high-affinity, potent and selective K (kappa) opioid receptor (KOR) antagonist (human K/μ/δ Ki = 0.565/35.8/211 nM against diprenorphine binding; GTP-γ-S binding IC50/agonist/subtype transfectant = 1.57 nM/300 nM U69593/K, 21.3 nM/1 μM DAMGO/μ 293 nM/30 nM DPDPE/d). LY2444296 reverses K agonist antinociceptive efficacy in vivo (ED50 = 0.24 mg/kg p.o. against 1 mg/kg U69593 sc. by r at formalin test), decreases immobility time (10 or 30 mg/kg sc.) and prevents enhanced alcohol consumption (5 mg/kg i.p.) among mice subjected to stress by forced swimming.
in vivo
LY2444296 displays anti-anxiety like effects in the EPM test[1].
LY2444296 (3 mg/kg; i.p.; 30 min before U69,593 administration) prevents behavioral and neuroendocrine effects caused by the reference kappa agonist U69,593 in cocaine-nave rats[2].
LY2444296 reduces anxiety-like and depressive-like behaviors, as well as CORT release, in rats tested after chronic extended access cocaine self-administration, but not in cocaine-nave rats[2].
| Animal Model: | Adult male Sprague Dawley rats (240–250 g)[2] |
| Dosage: | 3 mg/kg |
| Administration: | Injected intraperitoneally; 30 min before U69,593 administration |
| Result: | Prevented behavioral and neuroendocrine effects caused by U69,593 in cocaine-nave rats. |
IC 50
κ Opioid Receptor/KOR
References
[1] Huang P, et al. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neurosci Lett. 2016 Feb 26;615:15-20. DOI:10.1016/j.neulet.2016.01.017
[2] Valenza M, et al. "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats". Psychopharmacology (Berl). 2017 Aug;234(15):2219-2231. DOI:10.1007/s00213-017-4647-0
(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9948 | 58 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4849 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 19372819560 | Sales@ATKchemical.com | China | 9627 | 58 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1946 | 55 |
View Lastest Price from (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide manufacturers
1346133-11-6((S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide)Related Search:
1of3
