Boc-L-2,4-diaminobutyric acid
- CAS No.
- 25691-37-6
- Chemical Name:
- Boc-L-2,4-diaminobutyric acid
- Synonyms
- BOC-DAB;BOC-DAB-OH;BOC-L-DAB-OH;N-alpha-Ac-Nγ(Tert-Butoxy)Carbonyl Dab-OH;BOC-L-2,4-DIAMINOBUTYRIC ACID;Boc-L-2,4-Dlaminobutyrlc Acid;N?Boc-L-2,4-diaminobutyric acid;Na-Boc-L-2,4-diaminobutyric acid;Nα-Boc-L-2,4-diaminobutyric acid
- CBNumber:
- CB2486642
- Molecular Formula:
- C9H18N2O4
- Molecular Weight:
- 218.25
- MDL Number:
- MFCD00236841
- MOL File:
- 25691-37-6.mol
| Melting point | 192-194 °C |
|---|---|
| Boiling point | 385.5±37.0 °C(Predicted) |
| Density | 1.160±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Methanol (Sparingly), Water (Slightly) |
| form | Powder |
| pka | 3?+-.0.10(Predicted) |
| color | White to off-white |
| optical activity | [α]/D +7.5±1°, c = 1 in methanol: water (1:1) |
| BRN | 4745487 |
| CAS DataBase Reference | 25691-37-6(CAS DataBase Reference) |
Boc-L-2,4-diaminobutyric acid price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2515 | (S)-4-Amino-2-(tert-butoxycarbonylamino)butyric Acid >98.0%(T) | 25691-37-6 | 1g | $65 | 2021-12-16 | Buy |
| TCI Chemical | A2515 | (S)-4-Amino-2-(tert-butoxycarbonylamino)butyric Acid >98.0%(T) | 25691-37-6 | 5g | $336 | 2025-07-31 | Buy |
| TRC | B657100 | Boc-L-2,4-diaminobutyricAcid | 25691-37-6 | 250mg | $45 | 2021-12-16 | Buy |
| Usbiological | 265137 | N-alpha-Boc-L-2,4-diaminobutyric acid | 25691-37-6 | 500mg | $333 | 2021-12-16 | Buy |
| Iris Biotech GmbH | BAA1087 | Boc-L-Dab-OH | 25691-37-6 | 5G | $236.25 | 2021-12-16 | Buy |
Boc-L-2,4-diaminobutyric acid Chemical Properties,Uses,Production
Uses
Boc-L-2,4-diaminobutyric acid is a reagent used to synthesize somatostatin antagonist. It can also be used to develop blood coagulation factor Xa inhibitors.
Synthesis
13726-85-7
25691-37-6
General procedure for the synthesis of (S)-4-amino-2-((tert-butoxycarbonyl)amino)butanoic acid from BOC-L-glutamine: to a mixed solution of (S)-5-amino-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid (2 g, 8.1 mmol) in DMF and water (1:1, v/v, 18 ml) was added pyridine (1.3 ml, 16.2 mmol). The reaction mixture was stirred at room temperature for 5-10 min. Subsequently, iodobenzene diacetate (3.92 g, 12.1 mmol) was added and the reaction was continued with stirring for 4 hours. After completion of the reaction, deionized water (100 ml) was added to the reaction mixture and extracted with ethyl acetate (3 x 100 ml). The organic phases were combined and washed sequentially with deionized water (100 ml) and saturated saline (100 ml), dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by ether milling and after evaporation of the product grades, 1.1 g (62% yield) of the target compound was obtained as a brown solid. LC-MS analysis showed m/z = 219.1 (M + H).
References
[1] Synthetic Communications, 2004, vol. 34, # 6, p. 1049 - 1056
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 15, p. 4650 - 4656
[3] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 1, p. 161 - 175
[4] Patent: WO2014/151472, 2014, A1. Location in patent: Paragraph 00340-00341
[5] Patent: WO2016/40315, 2016, A1. Location in patent: Paragraph 00383; 00384
Boc-L-2,4-diaminobutyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8617390183901 | cynthia@enlaibio.com | China | 1100 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8829 | 58 |
View Lastest Price from Boc-L-2,4-diaminobutyric acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-15 | Boc-Dab-OH
25691-37-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2019-07-06 | Boc-L-2,4-diaminobutyric acid
25691-37-6
|
US $1.00 / KG | 1KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
-
- Boc-Dab-OH
25691-37-6
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Boc-L-2,4-diaminobutyric acid
25691-37-6
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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