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ChemicalBook >> CAS DataBase List >>11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt

11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt

11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt Structure
11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt structure
CAS No.
1421610-21-0
Chemical Name:
11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt
Synonyms
JNK Inhibitor XV;IQ-1S, JNK3 inhibitor;11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt
CBNumber:
CB24902650
Molecular Formula:
C15H10N3NaO
Molecular Weight:
271.25
MDL Number:
MFCD30182320
MOL File:
1421610-21-0.mol
Last updated:2025-08-06 15:14:14
Product description Number Pack Size Price
IQ1S I748580 100mg $1275
Request For Quotation

11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt Properties

storage temp. -20°C
solubility Soluble in DMSO (up to 15 mg/ml)
form solid
color Yellow
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

HS Code  2934999090

11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC I748580 IQ1S 1421610-21-0 100mg $1275 2021-12-16 Buy
Product number Packaging Price Buy
I748580 100mg $1275 Buy

11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt Chemical Properties,Uses,Production

Description

IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppressive activity. Inhibits LPS-induced proinflammatory cytokine and nitric oxide release?in vitro.1?Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity?in vivo.2

Uses

IQ 1S is a JNK inhibitor which inhibits LPS-induced proinflammatory.

in vivo

When mice are dosed with 12.5 and 30 mg/kg IQ-1S (The sodium salt of IQ-1) i.p., the serum exposure of the compound is also good, with AUC0-12h values of 2.9 and 7.4 μM/h, respectively[1].

IC 50

JNK3: 87 nM (Kd); JNK2: 360 nM (Kd); JNK1: 390 nM (Kd); PI3Kγ: 1.2 μM (Kd); CK1δ: 1.4 μM (Kd); MKNK2: 1.8 μM (Kd)

References

[1] IGOR A SCHEPETKIN. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.[J]. Molecular Pharmacology, 2012, 81 6: 832-845. DOI:10.1124/mol.111.077446
[2] IGOR A SCHEPETKIN. Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2015, 353 3: 505-516. DOI:10.1124/jpet.114.220251

11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
BOC Sciences -- info@bocsci.com USA 0 65
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44815 58
cjbscvictory 13348960310 3003867561@qq.com China 10505 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 6051 58
Santa Cruz Biotechnology Inc 021-60936350 scbt@scbt.com China 6594 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 65
Energy Chemical 58
cjbscvictory 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
Santa Cruz Biotechnology Inc 58

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11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt JNK Inhibitor XV IQ-1S, JNK3 inhibitor 1421610-21-0