SNX 482
- CAS No.
- 203460-30-4
- Chemical Name:
- SNX 482
- Synonyms
- SNX-482 Recombinant;SNX-482 (0.1mg vial);C192H274N52O60S7 M.W. 4495.01;SNX 482, R-Type Ca2+ (Cav2.3) channel blocker
- CBNumber:
- CB2497374
- Molecular Formula:
- C192H274N52O60S7
- Molecular Weight:
- 4494.99736
- MDL Number:
- MFCD02688906
- MOL File:
- 203460-30-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SNX-482 Recombinant ≥98% (HPLC) | SML1150 | 5μG | $238 |
| SNX-482 - CAS 203460-30-4 - Calbiochem | 5.08512 | 10μg | $192 |
| SNX 482 Asreported | 256714 | 10ug | $446 |
| SNX-482 | PCB-4363-S | 0.1mg | $1344.42 |
| SNX 482 | DIA46030 | 1mg | $32719.8 |
| storage temp. | −20°C |
|---|---|
| solubility | aqueous buffer: soluble |
| form | lyophilized powder |
| color | White to off-white |
| biological source | (from Hysterocrates gigas (African tarantula)) |
| Water Solubility | Soluble in water |
| Sequence | Gly-Val-Asp-Lys-Ala-Gly-Cys-Arg-Tyr-Met-Phe-Gly-Gly-Cys-Ser-Val-Asn-Asp-Asp-Cys-Cys-Pro-Arg-Leu-Gly-Cys-His-Ser-Leu-Phe-Ser-Tyr-Cys-Ala-Trp-Asp-Leu-Thr-Phe-Ser-Asp (Disulfide bridge:Cys7-Cys21;Cys14-Cys26;Cys20-Cys33) |
| InChIKey | NSUPRLHDCFNOKD-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SNX 482 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1150 | SNX-482 Recombinant ≥98% (HPLC) | 203460-30-4 | 5μG | $238 | 2026-04-30 | Buy |
| Sigma-Aldrich | 5.08512 | SNX-482 - CAS 203460-30-4 - Calbiochem | 203460-30-4 | 10μg | $192 | 2026-04-30 | Buy |
| Usbiological | 256714 | SNX 482 Asreported | 203460-30-4 | 10ug | $446 | 2026-06-03 | Buy |
| Biosynth | PCB-4363-S | SNX-482 | 203460-30-4 | 0.1mg | $1344.42 | 2026-06-04 | Buy |
| Biosynth | DIA46030 | SNX 482 | 203460-30-4 | 1mg | $32719.8 | 2026-06-04 | Buy |
SNX 482 Chemical Properties,Uses,Production
Uses
SNX-482, a peptide, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect[1][2][3].
Biological Activity
SNX-482 is a peptidyl toxin originally isolated from the venom of the spider Hysterocrates gigas. SNX-482 specifically blocks Cav2.3 (a1E, R-type) calcium channels in a voltage dependent manner. SNX-482 also blocks P/Q-type voltage-gated Ca2+ channels and blocks A-type K+ channels (IC50 of <3 nm).
in vivo
SNX-482 (0.5-4 μg/5 0μL; applied directly onto the spinal cord; 14-17 days post-operation) in the spinal nerve ligation (SNL) rat model dose - dependently inhibits nociceptive C-fiber and Aδ-fiber-mediated neuronal responses, and the responses to non-noxious mechanical and thermal stimuli are more sensitive in SNL rats than in sham - operated rats[3].
| Animal Model: | Male Sprague-Dawley rats (initially weighing 130-150 g) + Spinal nerve ligation[3] |
| Dosage: | 0.5 μg/50 μL, 1.5 μg/50 μL, 4 μg/50 μL |
| Administration: | Applied directly onto the spinal cord, 14-17 days post-operation |
| Result: | Exerted a significant dose-related inhibitory effect on C-fiber evoked responses, Aδ-fiber responses, post-discharge and input measurements. Inhibited the "wind-up" of neurons. |
storage
-20°C (desiccate)
References
[1] R Newcomb, et al. Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry. 1998 Nov 3;37(44):15353-62. DOI:10.1021/bi981255g
[2] E Bourinet, et al. Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels. Biophys J. 2001 Jul;81(1):79-88. DOI:10.1016/S0006-3495(01)75681-0
[3] Elizabeth A Matthews, et al. The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur J Neurosci. 2007 Jun;25(12):3561-9. DOI:10.1111/j.1460-9568.2007.05605.x
SNX 482 Preparation Products And Raw materials
Raw materials
Preparation Products
SNX 482 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10457 | 58 |
| Nanjing TGpeptide | +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
| LEON (NANJING) BIOTECHNOLOGY CO., LTD. | +8615051830413 | sales.njleonbiotech@gmail.com | China | 5482 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
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