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Fti 277 hydrochloride

Fti 277 hydrochloride Structure
Fti 277 hydrochloride structure
CAS No.
180977-34-8
Chemical Name:
Fti 277 hydrochloride
Synonyms
CS-1757;FTI 277 HCl;FTI 277 HCL;FTI 277;Fti 277 hydrochloride;FTI-277 TRIFLUOROACETATE SALT;FTI 277 HYDROCHLORIDE USP/EP/BP;FTI-277 hydrochloride, 10 mM in DMSO;4-[2(R)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(S)-methionine methyl ester hydrochloride;(S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate FTI 277 HCl;(S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate hydrochloride
CBNumber:
CB2503510
Molecular Formula:
C22H30ClN3O3S2
Molecular Weight:
484.075
MDL Number:
MFCD28385886
MOL File:
180977-34-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:19
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Fti 277 hydrochloride Properties

storage temp. Inert atmosphere,2-8°C
solubility H2O: soluble
form amorphous semi-solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

Fti 277 hydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10011667 FTI-277 (hydrochloride) ≥98% 261636-47-9 5mg $138 2026-04-30 Buy
Cayman Chemical 10011667 FTI-277 (hydrochloride) ≥98% 261636-47-9 10mg $262 2026-04-30 Buy
Cayman Chemical 10011667 FTI-277 (hydrochloride) ≥98% 261636-47-9 50mg $757 2026-04-30 Buy
Cayman Chemical 10011667 FTI-277 (hydrochloride) ≥98% 261636-47-9 100mg $1100 2026-04-30 Buy
Biosynth FHA97734 FTI-277 hydrochloride 180977-34-8 1mg $178.48 2026-06-04 Buy
Product number Packaging Price Buy
10011667 5mg $138 Buy
10011667 10mg $262 Buy
10011667 50mg $757 Buy
10011667 100mg $1100 Buy
FHA97734 1mg $178.48 Buy

Fti 277 hydrochloride Chemical Properties, Uses, Production

Uses

FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.

Biological Activity

fti-277 is a highly potent and selective ftase inhibitor. at concentration as low as 10 nm, fti-277 inhibits h-ras processing and the processing is blocked by more than 95% at 3 μm. [1]ras proteins are plasma membrane-associated gtpases. it acts as relay switches transducing biological information from extracellular signals to the nucleus. farnesyltransferase (ftase) is an enzyme that catalyzed the ras farnesylation, a lipid posttranslational modification that is required for ras-induced malignant transformation. [1]fti-277, the methyl ester derivative of fti-276, is extremely potent (icgraphic = 100 nm) at inhibiting h-ras, but not the geranylgeranylated rap1a processing in whole cells. fti-277 is a farnesylation-specific inhibitor which inhibits the processing of both oncogenic and normal ras. [1]in mice that hydrodynamically transfected to produce hepatitis delta virus (hdv) viremia, fti-277 treatment is effective in inhibiting viremia. [2]

in vitro

FTI-277 inhibits Ras processing with an IC50 of 100 nM, but not the geranylgeranylated Rap1A processing in whole cells. It induces accumulation of cytoplasmic non-farnesylated H-Ras, accumulates inactive Ras/Raf complexes in the cytoplasm, and constitutive blocksive MAPK activation in H-RasF cells. It causes increased after irradiation and increases radiosensitivity in H-ras-transformed rat embryo cells. FTI-277 also inhibits cell growth and induces apoptosis in drug-resistant myeloma tumor cells. In SH- apoptosis SY5Y cells, It diminishes the toxic effects of methamphetamine on induction in cell degeneration, activation in c-Jun-N-terminal kinase cascades, and Ras activation.

in vivo

In mice coinfected with hepatitis B virus (HBV) and HDV, FTI-277 (50 mg/kg/d ip) effectively clears HDV viremia.

References

1. bordier bb, ohkanda j, liu p et al. in vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. j clin invest. 2003 aug;112(3):407-14.2. lerner ec, qian y, blaskovich ma et al. ras caax peptidomimetic fti-277 selectively blocksoncogenic ras signaling by inducing cytoplasmic accumulation of inactive ras-raf complexes. j biol chem. 1995 nov 10;270(45):26802-6. pubmed pmid: 7592920.

Fti 277 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Fti 277 hydrochloride Suppliers

Global Suppliers ( 117)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Pharmacodia (Beijing) Co.,Ltd +86-400-851-9921 sales@pharmacodia.com China 2308 55
Supplier Advantage
BOC Sciences 65
Dalian Meilun Biotech Co., Ltd. 58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Bide Pharmatech Ltd. 60
LETOPHARM LIMITED 58
Sigma-Aldrich 80
Shanghai Lollane Biological Technology Co.,Ltd. 55
BOC Sciences 65
Pharmacodia (Beijing) Co.,Ltd 55

View Latest Price from Fti 277 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FTI-277 hydrochloride pictures 2026-07-27 FTI-277 hydrochloride
180977-34-8
 $48.00-97.00 97.57% 10g TargetMol Chemicals Inc.

Fti 277 hydrochloride Spectrum

FTI 277 HYDROCHLORIDE(180977-34-8)1HNMR

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CS-1757 4-[2(R)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(S)-methionine methyl ester hydrochloride FTI-277 TRIFLUOROACETATE SALT FTI 277 HCl (S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate FTI 277 HCl FTI 277 HCL;FTI 277 FTI 277 HYDROCHLORIDE USP/EP/BP (S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate hydrochloride FTI-277 hydrochloride, 10 mM in DMSO Fti 277 hydrochloride 180977-34-8 C22H30ClN3O3S2 Inhibitors