GLP-1 receptor agonist 5
- CAS No.
- 1246826-07-2
- Chemical Name:
- GLP-1 receptor agonist 5
- Synonyms
- TT-OAD2 free base;GLP-1 receptor agonist 5;(S)-2-{[(3S,8S)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-7-((S)-1-phenyl-propyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl]-amino};L-Phenylalanine, N-[[(3S,8S)-3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2,3,6,7,8,9-hexahydro-7-[(1S)-1-phenylpropyl]-1,4-dioxino[2,3-g]isoquinolin-8-yl]carbonyl]-4-(2,3-dimethyl-4-pyridinyl)-
- CBNumber:
- CB25544448
- Molecular Formula:
- C50H47Cl2N3O6
- Molecular Weight:
- 856.83
- MDL Number:
- MFCD34469614
- MOL File:
- 1246826-07-2.mol
- TDS File:
- TDS
GLP-1 receptor agonist 5 Chemical Properties, Uses, Production
Uses
TT-OAD2 free base is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM. TT-OAD2 free base has the potential for diabetes treatment[1][2].
in vivo
TT-OAD2 (3 mg/kg; intravenous injection; male human GLP-1 receptor knock-in and knockout mice) treatment induces plasma insulin in an acute IVGTT on humanized GLP-1R knock-in (KI) and GLP-1R knockout (KO) mice[1].
| Animal Model: | Male human GLP-1 receptor knock-in and knockout mice (6-11 months of age) with intravenous glucose tolerance tests[1] |
| Dosage: | 3 mg/kg |
| Administration: | Intravenous injection (Single dose) |
| Result: | Induced plasma insulin. |
References
[1] Zhao P, et al. Activation of the GLP-1 receptor by a non-peptidic agonist. Nature. 2020 Jan;577(7790):432-436. DOI:10.1038/s41586-019-1902-z
[2] Transtech Pharma, et al. Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof. WO2010114824A1.
GLP-1 receptor agonist 5 Preparation Products And Raw materials
Raw materials
Preparation Products
GLP-1 receptor agonist 5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 3905209149@qq.com | China | 9705 | 58 |
| Wuhan Topule | +86-02787215551 19945035818 | 2936752263@qq.com | China | 7983 | 58 |
| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11706 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2223443625@qq.com | China | 7998 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 1276242629@qq.com | China | 9977 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17521512546 17721492509 | 460170712@qq.com | China | 4996 | 58 |
