Phospho-mTOR (Ser2448) Antibody

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

The mammalian target of rapamycin is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1. These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy.

References

[1] Sabers, C.J. et al. (1995) J Biol Chem 270, 815-22.
[2] Brown, E.J. et al. (1994) Nature 369, 756-8.
[3] Sabatini, D.M. et al. (1994) Cell 78, 35-43.
[4] Gingras, A.C. et al. (2001) Genes Dev 15, 807-26.
[5] Dennis, P.B. et al. (2001) Science 294, 1102-5.
[6] Fang, Y. et al. (2001) Science 294, 1942-5.
[7] Navé, B.T. et al. (1999) Biochem J 344 Pt 2, 427-11.
[8] Peterson, R.T. et al. (2000) J Biol Chem 275, 7416-23.
[9] Huang, S. and Houghton, P.J. (2003) Curr Opin Pharmacol 3, 371-7.

Raw materials

Preparation Products