SOCS2 antibody
- CAS No.
- Chemical Name:
- SOCS2 antibody
- Synonyms
- SOCS2 antibody
- CBNumber:
- CB25697120
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
SOCS2 antibody price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb622656 | SOCS2 Antibody | 50μl | $400 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb622656 | SOCS2 Antibody | 100μl | $540 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb252277 | SOCS2 Antibody | 100μl | $360 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb13692 | SOCS2 antibody Affinity purified by Protein A | 100μg | $402.9 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb27595 | SOCS2 antibody Immunogen affinity purified. | 100μg | $523.6 | 2021-12-16 | Buy |
SOCS2 antibody Chemical Properties, Uses, Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
The suppressor of cytokine signaling family members are negative regulators of cytokine signal transduction that inhibit the Jak/Stat pathway. The SOCS family consists of at least 8 members including the originally identified cytokine-inducible SH2-containing protein, as well as SOCS1-7. Each SOCS family member contains a central SH2 domain and a conserved carboxy-terminal motif designated as the SOCS box. These proteins are important regulators of cytokine signaling, proliferation, differentiation, and immune responses.Activity of SOCS2 has been predominantly linked to growth hormone and insulin-like growth factor 1 signaling but may also contribute to several biological processes including metabolism, bone formation, neuronal development, cancer, infection and other cytokine-dependent pathways. SOCS2 is widely expressed in adult and fetal tissues and is induced upon cytokine treatment. A number of studies suggest that SOCS2 can have either a positive or negative effect on GH/cytokine signaling. Mice deficient in SOCS2 grow signficantly larger than normal littermates. SOCS2 binds to tyrosine-phosphorylated GH and IGF-1 receptors via its SH2 domain, suppressing their signaling. In addition, the SOCS box of SOCS2 binds to Elongin B and C leading to activity as a ubiquitin ligase, promoting the degradation of the receptors as well as other SOCS family members.
References
[1] Alexander, W.S. et al. (1999) J Leukoc Biol 66, 588-92.
[2] Chen, X.P. et al. (2000) Immunity 13, 287-90.
[3] Hilton, D.J. et al. (1998) Proc Natl Acad Sci USA 95, 114-9.
[4] Rico-Bautista, E. et al. (2006) Cytokine Growth Factor Rev 17, 431-9.
[5] Starr, R. et al. (1997) Nature 387, 917-21.
[6] Dey, B.R. et al. (1998) J Biol Chem 273, 24095-101.
[7] Favre, H. et al. (1999) FEBS Lett 453, 63-6.
[8] Metcalf, D. et al. (2000) Nature 405, 1069-73.
[9] Greenhalgh, C.J. et al. (2002) J Biol Chem 277, 40181-4.
[10] Greenhalgh, C.J. et al. (2005) J Clin Invest 115, 397-406.
SOCS2 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
SOCS2 antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 027-19371278702 18008634902 | 19384116026@163.com | China | 3008 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 58 |
