3-Fluorophenylacetic acid
- CAS No.
- 331-25-9
- Chemical Name:
- 3-Fluorophenylacetic acid
- Synonyms
- 2-(3-Fluorophenyl)acetic Acid;M-FLUOROPHENYLACETIC ACID;RARECHEM AL BO 0121;3-Fluorophenylacetic;3-Fluorophenlacetic acid;Between the fluorine acid;3-fluoro-benzeneaceticaci;3-FLUOROPHENYLACETIC ACID;3-fluoro-benzeneacetic acid;3-Fluorophenylaceticacid98%
- CBNumber:
- CB2691734
- Molecular Formula:
- C8H7FO2
- Molecular Weight:
- 154.14
- MDL Number:
- MFCD00004331
- MOL File:
- 331-25-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Fluorophenylacetic acid 98% | 248045 | 5g | $74.6 |
| 3-Fluorophenylacetic Acid >98.0%(GC)(T) | F0216 | 5g | $46 |
| 3-Fluorophenylacetic Acid >98.0%(GC)(T) | F0216 | 25g | $140 |
| 3-Fluorophenylacetic acid 97% | PC4130 | 25g | $21 |
| 3-Fluorophenylacetic acid 97% | PC4130 | 100g | $47 |
| More product size | |||
| Melting point | 42-44 °C (lit.) |
|---|---|
| Boiling point | 151 °C |
| Density | 1.1850 (estimate) |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.10±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | Slightly soluble in chloroform and methanol. Insoluble in water. |
| BRN | 775898 |
| InChI | InChI=1S/C8H7FO2/c9-7-3-1-2-6(4-7)5-8(10)11/h1-4H,5H2,(H,10,11) |
| InChIKey | YEAUYVGUXSZCFI-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=CC=CC(F)=C1 |
| CAS DataBase Reference | 331-25-9(CAS DataBase Reference) |
| FDA UNII | 4CP7BU47LD |
| NIST Chemistry Reference | M-fluorophenylacetic acid(331-25-9) |
| EPA Substance Registry System | Benzeneacetic acid, 3-fluoro- (331-25-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280g-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 38-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163900 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| NFPA 704 |
|
3-Fluorophenylacetic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 248045 | 3-Fluorophenylacetic acid 98% | 331-25-9 | 5g | $74.6 | 2023-06-20 | Buy |
| TCI Chemical | F0216 | 3-Fluorophenylacetic Acid >98.0%(GC)(T) | 331-25-9 | 5g | $46 | 2026-04-30 | Buy |
| TCI Chemical | F0216 | 3-Fluorophenylacetic Acid >98.0%(GC)(T) | 331-25-9 | 25g | $140 | 2026-04-30 | Buy |
| Apolloscientific | PC4130 | 3-Fluorophenylacetic acid 97% | 331-25-9 | 25g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC4130 | 3-Fluorophenylacetic acid 97% | 331-25-9 | 100g | $47 | 2026-06-04 | Buy |
3-Fluorophenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
White to pale yellow or light beige crystalline
Uses
3-Fluorophenylacetic acid has been used as building block to synthesize the pentaamine and bis-heterocyclic libraries. It is also used as a medicine intermediates.
Uses
3-Fluorophenylacetic acid has been used as building block to synthesize the pentaamine and bis-heterocyclic libraries.
Synthesis
Preparation of m-fluorophenylacetic acid: 350 g of 32% HCl and 250 g of 3-fluoroaniline were added to the reaction flask, heated and stirred until dissolved clear. Cool down to -5 to 5 , 20 g tetramethyl ammonium chloride and 20 g copper chloride. Acetone solution containing 300 g of vinylidene chloride was added dropwise. Maintaining the temperature, slowly add dropwise a solution containing 230 g of isopropyl nitrite and 200 g of acetone. Hold the reaction for 2 hours. The reaction was completed and quenched. Dichloromethane was added and extracted and distilled and collected to give 1-(2,2,2-trichloroethyl)-3-fluorobenzene 398 g. A three-necked flask was protected with nitrogen and 500 g of water and 60 g of p-toluenesulfonic acid were added. Heated to 80-95C. 300g of intermediate 1-(2,2,2-trichloroethyl)-3-fluorobenzene was added dropwise. Dropwise addition was completed and the reaction was held for 8 hours. The reaction was completed. The system was quenched by adding dropwise to ice water at reduced temperature. Filtered, washed with water, dried and recrystallized with dichloroethane to obtain the pure m-fluorophenylacetic acid 151.2 g, HPLC purity greater than 99 wt%.
3-Fluorophenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cangzhou Kangrui Pharma Tech Co. Ltd., | +86-18632776803 +86-13833998158 | cangzhoukangrui@126.com | China | 773 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
View Lastest Price from 3-Fluorophenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-28 | 3-Fluorophenylacetic acid
331-25-9
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-05-21 | 3-Fluorophenylacetic acid
331-25-9
|
1Kg/Drum | 99% | 100mt/year | Jinan Finer Chemical Co., Ltd | ||
 |
2025-09-25 | 3-Fluorophenylacetic acid
331-25-9
|
$9.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- 3-Fluorophenylacetic acid
331-25-9
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3-Fluorophenylacetic acid
331-25-9
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 3-Fluorophenylacetic acid
331-25-9
- $9.00
- 99%
- Henan Fengda Chemical Co., Ltd
