TEBBE REAGENT
- CAS No.
- 67719-69-1
- Chemical Name:
- TEBBE REAGENT
- Synonyms
- tebbe;Tebbe reag;TEBBE REAGENT;Tebbe's reagent;tebbe reagent solution;ca.0.5mol/lToluenesolution;Tebbe Reagent 0.5 M in Toluene;TEBBE REAGENT ISO 9001：2015 REACH;TEBBE REAGENT, 0.5M SOLUTION IN TOLUENE;Tebbe Reagent (ca. 0.5mol/L in Toluene)
- CBNumber:
- CB2693440
- Molecular Formula:
- C13H4AlClTi
- Molecular Weight:
- 270.47
- MDL Number:
- MFCD00151575
- MOL File:
- 67719-69-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Tebbe reagent solution 0.5 M in toluene | 380237 | 25ml | $325 |
| Tebbe reagent solution 0.5 M in toluene | 380237 | 4x25ml | $529 |
| Tebbe reagent solution 0.5 M in toluene | 380237 | 100ml | $1230 |
| Tebbereagentsolution,0.5Mintoluene | H408 | 5mL | $265 |
| Density | 0.96 g/mL at 20 °C |
|---|---|
| Flash point | 34 °F |
| storage temp. | Refrigerator |
| form | Solution |
| color | Dark red to purple |
| Water Solubility | Soluble in toluene, benzene, dichloromethane. Insoluble in water. |
| Sensitive | Air & Moisture Sensitive |
| Merck | 9091 |
| Exposure limits |
ACGIH: TWA 20 ppm OSHA: Ceiling 300 ppm; TWA 200 ppm NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3) |
| InChI | InChI=1S/2C5.2CH2.C.Al.ClH.Ti/c2*1-2-4-5-3-1;;;;;;/h;;2*1H2;;;1H;/q4*-1;-2;+3;;+4/p-1 |
| InChIKey | QEJAQNUJXFLWSP-UHFFFAOYSA-M |
| SMILES | [CH2-][Al+3]1([Cl-][Ti+4]23456789(C%10[C-]2C3=C4C5=%10)(C2[C-]6C7=C8C9=2)[C-2]1)[CH2-] |
| FDA UNII | V040SDB67S |
| UNSPSC Code | 12352101 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H261-H302-H318-H333-H361-H225-H304-H314-H336-H361d-H373 | |||||||||
| Precautionary statements | P223-P301+P310a-P303+P361+P353-P405-P501a-P210-P261-P280-P301+P310-P305+P351+P338-P310 | |||||||||
| target organs | Central nervous system, Respiratory system | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | F,C | |||||||||
| Risk Statements | 11-34-48/20-63-65-67 | |||||||||
| Safety Statements | 26-36/37/39-45-62-16 | |||||||||
| RIDADR | UN 2924 3/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 1-10 | |||||||||
| HazardClass | 4.3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29310099 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Aquatic Chronic 3 Asp. Tox. 1 Eye Dam. 1 Flam. Liq. 2 Repr. 2 Skin Corr. 1B STOT RE 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
TEBBE REAGENT price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 380237 | Tebbe reagent solution 0.5 M in toluene | 67719-69-1 | 25ml | $325 | 2026-04-30 | Buy |
| Sigma-Aldrich | 380237 | Tebbe reagent solution 0.5 M in toluene | 67719-69-1 | 4x25ml | $529 | 2026-04-30 | Buy |
| Sigma-Aldrich | 380237 | Tebbe reagent solution 0.5 M in toluene | 67719-69-1 | 100ml | $1230 | 2026-04-30 | Buy |
| AK Scientific | H408 | Tebbereagentsolution,0.5Mintoluene | 67719-69-1 | 5mL | $265 | 2021-12-16 | Buy |
TEBBE REAGENT Chemical Properties,Uses,Production
Chemical Properties
The Tebbe reagent is the organometallic compound with the formula (CH)TiCHClAl(CH). It is used in the methylenation of carbonyl compounds, that is it converts organic compounds containing the RC=O group into the related RC=CH derivative.It is a red solid that is pyrophoric in the air, and thus is typically handled with air-free techniques. It was originally synthesized by Fred Tebbe at DuPont Central Research. Tebbe's reagent contains two tetrahedral metal centers linked by a pair of bridging ligands. The titanium has two cyclopentadienyl ([CH]-, or Cp) rings and aluminium has two methyl groups. The titanium and aluminium atoms are linked together by both a methylene bridge (-CH-) and a chloride atom in a nearly square-planar (Ti–CH–Al–Cl) geometry.The Tebbe reagent was the first reported compound where a methylene bridge connects a transition metal (Ti) and a main group metal (Al).Preparation The Tebbe reagent is synthesized from titanocene dichloride and trimethylaluminium in toluene solution.
Chemical Properties
Dark red to purple solution
Uses
Reagent for the methylenation of carbonyl groups.
Uses
Tebbe reagent can be used:
- For the conversion of carbonyl groups of chlorophyll derivatives into the corresponding exo-methylene (or vinylidene) groups.
- In the synthesis of β-C-glycosides from 3-OH glycol esters.
- As a versatile methylenation reagent for the conversion of ketones and aldehydes to olefins. It offers facile reaction with hindered ketones and allows the conversion of esters to vinyl ethers.
- To olefinate aldehydes.
- To methylenate a chiral polyhydroxyketone with high diasteroselctivity.
Uses
μ-Chloro-μ-methylenebis(cyclopentadienyl)titaniumdimethylaluminum is used in organic synthesis for carbonyl methylenation, A versatile methylenation reagent for the conversion of ketones and aldehydes to olefins, it offers facile reaction with hindered ketones and allows the conversion of esters to vinyl ethers. Tebbe reagent can be used to olefinate aldehydes, to methylenate a chiral polyhydroxyketone with high diasteroselctivity.
General Description
Tebbe reagent is a Lewis acid stabilized organometallic compound, which is used to transform carbonyl groups into β-substituted methylenes. It also reacts with a wide range of carbonyl compounds, including esters, amides, and lactones to yield corresponding olefins.
reaction suitability
reaction type: C-C Bond Formation
TEBBE REAGENT Preparation Products And Raw materials
Raw materials
Preparation Products
TEBBE REAGENT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 10000 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
| Huangshi Bo’Er Chemical Co., Ltd. | 0714-6401888 18671400300 | 273568016@qq.com | China | 583 | 58 |
| Panjin Infinity Scientific CO. LTD | 400-1062016 18612996721 | hao@infsci.com | China | 327 | 58 |
View Lastest Price from TEBBE REAGENT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | TEBBE REAGENT
67719-69-1
|
US $8.00-1.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- TEBBE REAGENT
67719-69-1
- US $8.00-1.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
