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L-858051

L-858051 Structure
L-858051 structure
CAS No.
115116-37-5
Chemical Name:
L-858051
Synonyms
L-858051;L-858,051 (hydrochloride);L858,051 (hydrochloride),L 858,051 (hydrochloride);7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL;7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride;Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride;Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride;FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE;8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL
CBNumber:
CB2703053
Molecular Formula:
C29H50Cl2N2O7
Molecular Weight:
609.62
MDL Number:
MFCD00077349
MOL File:
Mol file
MSDS File:
SDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
L-858,051 (hydrochloride) ≥95% 21206 500μg $36
L-858,051 (hydrochloride) ≥95% 21206 1mg $66
L-858,051 (hydrochloride) ≥95% 21206 5mg $277
[(3R,4Ar,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]4-(4-methylpiperazin-1-yl)butanoate;dihydrochloride 1919CV 1mg $174
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L-858051 Properties

storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
form A crystalline solid
color white
Water Solubility water: 12mg/mL
methanol: soluble
InChIKey OAJWVIUBCCGPBN-BAPSXVLWSA-N
SMILES Cl.Cl.N4(CCN(CC4)C)CCCC(=O)O[C@@H]1[C@]2(O[C@@](CC(=O)[C@@]2([C@@]3([C@@H]([C@@H]1O)C(CC[C@@H]3O)(C)C)C)O)(C)C=C)C
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

L-858051 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21206 L-858,051 (hydrochloride) ≥95% 115116-37-5 500μg $36 2023-06-20 Buy
Cayman Chemical 21206 L-858,051 (hydrochloride) ≥95% 115116-37-5 1mg $66 2023-06-20 Buy
Cayman Chemical 21206 L-858,051 (hydrochloride) ≥95% 115116-37-5 5mg $277 2023-06-20 Buy
AK Scientific 1919CV [(3R,4Ar,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]4-(4-methylpiperazin-1-yl)butanoate;dihydrochloride 115116-37-5 1mg $174 2021-12-16 Buy
Product number Packaging Price Buy
21206 500μg $36 Buy
21206 1mg $66 Buy
21206 5mg $277 Buy
1919CV 1mg $174 Buy

L-858051 Chemical Properties,Uses,Production

Description

L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase.1 L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes.2 L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.3,4,5

References

1. Laurenza, A., Khandelwal, Y., De Souza, N.J., et al. Stimulation of adenylate cyclase by water-soluble analogues of forskolin Mol. Pharmacol. 32(1),133-139(1987).
2. Joost, H.G., Habberfield, A.D., Simpson, I.A., et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action Mol. Pharmacol. 33(4),449-453(1988).
3. Funaki, C., Hodges, R.R., and Dartt, D.A. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland Am. J. Physiol. Cell Physiol. 293(5),C1551-C1560(2007).
4. Luo, S.-F., Chiu, C.-T., Tsao, H.-L., et al. Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells Cell. Signal. 9(2),159-167(1997).
5. Haj Slimane, Z., Bedioune, I., Lechêne, P., et al. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes Cardiovasc. Res. 102(1),97-106(2014).

L-858051 Preparation Products And Raw materials

Raw materials

Preparation Products

L-858051 Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19956 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24955 58
Enzo Biochem Inc -- Enzoname@qq.com China 6174 58
Merck KGaA -- ordercn@merckgroup.com China 6394 58
Biosynth Biological Technology (Suzhou) Co Ltd -- sales@biosynth.com China 6051 58
Santa Cruz Biotechnology Inc -- scbt@scbt.com China 6594 58
Guangzhou Qingyan Biotechnology Co., Ltd. -- CHINA 6470 58
Foshan Minghua Biotechnology Co., Ltd. -- CHINA 6496 58
Supplier Advantage
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
Enzo Biochem Inc 58
Merck KGaA 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
Santa Cruz Biotechnology Inc 58
Guangzhou Qingyan Biotechnology Co., Ltd. 58
Foshan Minghua Biotechnology Co., Ltd. 58

View Lastest Price from L-858051 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-858,051 (hydrochloride) pictures 2026-04-22 L-858,051 (hydrochloride)
115116-37-5
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

115116-37-5(L-858051)Related Search:

Forskolin
8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL 7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL L-858051 FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE L-858,051 (hydrochloride) L858,051 (hydrochloride),L 858,051 (hydrochloride) Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride 115116-37-5