Protionamide
- CAS No.
- 14222-60-7
- Chemical Name:
- Protionamide
- Synonyms
- PROTHIONAMIDE;protion;1321th;peteha;ektebin;tuberex;RP 9778;TH-1321;9778r.p.;tebeform
- CBNumber:
- CB2705774
- Molecular Formula:
- C9H12N2S
- Molecular Weight:
- 180.27
- MDL Number:
- MFCD00464119
- MOL File:
- 14222-60-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Prothionamide ≥99% (HPLC) | SMB00387 | 1 g | $93.7 |
| Prothionamide ≥99% (HPLC) | SMB00387 | 10 g | $484 |
| Prothionamide >98.0%(HPLC)(T) | P2302 | 5g | $42 |
| Prothionamide >98.0%(HPLC)(T) | P2302 | 25g | $137 |
| Prothionamide ≥98% | 16074 | 500mg | $41 |
| More product size | |||
| Melting point | 140-143°C |
|---|---|
| Boiling point | 310.4±44.0 °C(Predicted) |
| Density | 1.1015 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 12.14±0.29(Predicted) |
| form | Solid |
| color | Yellow |
| Merck | 14,7891 |
| InChI | InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12) |
| InChIKey | VRDIULHPQTYCLN-UHFFFAOYSA-N |
| SMILES | C1(CCC)=NC=CC(C(N)=S)=C1 |
| CAS DataBase Reference | 14222-60-7(CAS DataBase Reference) |
| FDA UNII | 76YOO33643 |
| ATC code | J04AD01 |
| UNSPSC Code | 51102829 |
| NACRES | NA.85 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS09,GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H319-H317-H335-H400-H242 | |||||||||
| Precautionary statements | P501-P261-P273-P272-P220-P210-P235-P234-P271-P264-P280-P302+P352-P391-P337+P313-P305+P351+P338-P362+P364-P333+P313-P304+P340+P312-P410-P420-P403+P233-P405 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| RTECS | NS0650000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in) | |||||||||
| NFPA 704 |
|
Protionamide price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00387 | Prothionamide ≥99% (HPLC) | 14222-60-7 | 1 g | $93.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | SMB00387 | Prothionamide ≥99% (HPLC) | 14222-60-7 | 10 g | $484 | 2025-07-31 | Buy |
| TCI Chemical | P2302 | Prothionamide >98.0%(HPLC)(T) | 14222-60-7 | 5g | $42 | 2026-04-30 | Buy |
| TCI Chemical | P2302 | Prothionamide >98.0%(HPLC)(T) | 14222-60-7 | 25g | $137 | 2026-04-30 | Buy |
| Cayman Chemical | 16074 | Prothionamide ≥98% | 14222-60-7 | 500mg | $41 | 2026-04-30 | Buy |
Protionamide Chemical Properties,Uses,Production
Chemical Properties
Protionamide is Yellow Solid
Uses
Protionamide is an antibacterial used against Mycobacterium tuberculosis bacteria.
Uses
An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).
Definition
ChEBI: Prothionamide is a member of pyridines.
Biological Activity
Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.
Synthesis
80944-48-5
14222-60-7
GENERAL METHODS: To a reaction flask containing pyridine-4-carboxamide derivatives (1 eq.) was added tetrahydrofuran (THF, 5 mL/millimole) at room temperature and protected by argon and mixed with stirring. Subsequently, Lawesson's reagent (1.5 eq.) was added to the reaction system and the reaction was continuously stirred at room temperature for 48 to 72 hours. Upon completion of the reaction, the THF solvent was removed by distillation under reduced pressure. The residue was extracted by partitioning with saturated aqueous sodium bicarbonate (25 mL) and ethyl acetate (25 mL), and the extraction was repeated with ethyl acetate (2 x 25 mL). The organic phases were combined and dried with anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under vacuum. Finally, the product was further purified by fast column chromatography (elution gradient: 0-3% methanol/dichloromethane, using a puriFlash 15-SI-HC 25G column, elution time 45 min).
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 159, p. 35 - 46
[2] Bulletin de la Societe Chimique de France, 1958, p. 687,691
Protionamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 1287 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Hebei Henghe Import and Export Trading Co. LTD | +8618032935937 18032916000 | demi@hbtycoon.com | CHINA | 448 | 58 |
View Lastest Price from Protionamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Prothionamide
14222-60-7
|
US $35.00 / mL | 99.34% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-21 | Prothionamide
14222-60-7
|
US $35.00 / mL | 99.34% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-11-18 | Protionamide USP/EP/BP
14222-60-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Prothionamide
14222-60-7
- US $35.00 / mL
- 99.34%
- TargetMol Chemicals Inc.
-
- Prothionamide
14222-60-7
- US $35.00 / mL
- 99.34%
- TargetMol Chemicals Inc.
-
- Protionamide USP/EP/BP
14222-60-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
