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Methyl 3-amino-4-hydroxybenzoate

Methyl 3-amino-4-hydroxybenzoate structure

CAS No.: 536-25-4

Chemical Name:: Methyl 3-amino-4-hydroxybenzoate

Synonyms: NSC9813;NSC 9813;NSC-9813;Orthoderm;Aminobenz;ORTHOFORM;Orthocain;ORTHOCAINE;Orthoform new;Mehyl3-aMino-4-hydroxybenzoate

CBNumber:: CB2712307

Molecular Formula:: C8H9NO3

Molecular Weight:: 167.16

MDL Number:: MFCD00017095

MOL File:: 536-25-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:45:55

Product description	Number	Pack Size	Price
Methyl 3-Amino-4-hydroxybenzoate min. 98.0 %	M3498	1G	$41
Methyl 3-Amino-4-hydroxybenzoate min. 98.0 %	M3498	5G	$139
Orthocaine	TRC-O697500-500MG	500mg	$65
Orthocaine	FO26589	50g	$285.5
Orthocaine	FO26589	100g	$552
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Methyl 3-amino-4-hydroxybenzoate Properties

Melting point	141-143
Boiling point	295.73°C (rough estimate)
Density	1.2917 (rough estimate)
refractive index	1.5810 (estimate)
RTECS	DG2625000
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	8.15±0.18(Predicted)
color	Beige
InChI	InChI=1S/C8H9NO3/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4,10H,9H2,1H3
InChIKey	VNQABZCSYCTZMS-UHFFFAOYSA-N
SMILES	C(OC)(=O)C1=CC=C(O)C(N)=C1
CAS DataBase Reference	536-25-4(CAS DataBase Reference)
FDA UNII	JK16YI13QK
NIST Chemistry Reference	Benzoic acid, 3-amino-4-hydroxy, methyl ester(536-25-4)
EPA Substance Registry System	Benzoic acid, 3-amino-4-hydroxy-, methyl ester (536-25-4)
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes	Xi,Xn
Risk Statements	22
WGK Germany	WGK 3
TSCA	TSCA listed
HazardClass	IRRITANT
HS Code	2922500090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Methyl 3-amino-4-hydroxybenzoate price More Price(85)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M3498	Methyl 3-Amino-4-hydroxybenzoate min. 98.0 %	536-25-4	1G	$41	2026-04-30	Buy
TCI Chemical	M3498	Methyl 3-Amino-4-hydroxybenzoate min. 98.0 %	536-25-4	5G	$139	2026-04-30	Buy
TRC	TRC-O697500-500MG	Orthocaine	536-25-4	500mg	$65	2026-06-03	Buy
Biosynth	FO26589	Orthocaine	536-25-4	50g	$285.5	2026-06-04	Buy
Biosynth	FO26589	Orthocaine	536-25-4	100g	$552	2026-06-04	Buy

Product number	Packaging	Price	Buy
M3498	1G	$41	Buy
M3498	5G	$139	Buy
TRC-O697500-500MG	500mg	$65	Buy
FO26589	50g	$285.5	Buy
FO26589	100g	$552	Buy

Methyl 3-amino-4-hydroxybenzoate Chemical Properties,Uses,Production

Chemical Properties

Beige Solid

Uses

Anesthetic (topical).

Definition

ChEBI: Orthoform is a benzoate ester.

Synthesis

67-56-1

1571-72-8

536-25-4

1. 3-Amino-4-hydroxybenzoic acid (0.40 g, 2.61 mmol) was dissolved in anhydrous methanol (10 mL), and trimethylsilyl chloride (TMSCl, 0.75 mL, 5.94 mmol) was added. 2. The reaction mixture was stirred at 55°C for 48 h. 3. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure. 4. The crude product was purified by silica gel column chromatography. The crude product was purified by silica gel column chromatography using ethyl acetate as eluent to afford methyl 3-amino-4-hydroxybenzoate (0.25 g, 1.50 mmol, 57% yield) as a white solid. 5. Methyl 3-amino-4-hydroxybenzoate (0.20 g) was dissolved in anhydrous tetrahydrofuran (THF, 10 mL), and methyl 3-amino-4-hydroxybenzoate was added to methyl 3-amino-4-hydroxybenzoate, 0.26 g, 1.5 mL, and methyl 3-amino-4-hydroxybenzoate, 0.20 g, 2.5 mL, 2.4 mL, 2.5 mL. (0.26 g, 1.46 mmol). 6. The reaction mixture was stirred at room temperature overnight. 7. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure. 8. The residue was treated with water (15 mL) and extracted with ethyl acetate (3 × 15 mL). 9. The organic layers were combined, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. 10. The crude product was recrystallized from ethanol to give 2-thioalkylbenzo[d ]oxazole-5-carboxylic acid methyl ester (21, 0.22 g, 1.05 mmol, 88% yield) as a brown solid with a melting point of 203-205°C. The crude product was extracted with ethanol.

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1314 - 1317
[2] Patent: WO2004/87714, 2004, A1. Location in patent: Page 53
[3] Patent: WO2014/95920, 2014, A1. Location in patent: Page/Page column 66
[4] European Journal of Organic Chemistry, 2011, # 1, p. 100 - 109
[5] Heterocycles, 2011, vol. 83, # 12, p. 2851 - 2856

Methyl 3-amino-4-hydroxybenzoate synthesis

Synthesis of Methyl 3-amino-4-hydroxybenzoate from Methanol and 3-Amino-4-hydroxybenzoic acid

Methyl 3-amino-4-hydroxybenzoate Preparation Products And Raw materials

Raw materials

Methyl 3-nitro-4-hydroxybenzoate Methanol (TRIMETHYLSILYL)DIAZOMETHANE Acetyl chloride 4-Hydroxy-3-nitrobenzoic acid

3-Amino-4-hydroxybenzoic acid

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Preparation Products

3-Amino-4-hydroxybenzoic acid METHYL 1,3-BENZOXAZOLE-5-CARBOXYLATE 5-Carboxy-8-hydroxyquinoline Methyl 2-ethylbenzo[d]oxazole-5-carboxylate

Methyl 3-amino-4-hydroxybenzoate Suppliers

Global( 191)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Nanjing jinheyou Trading Co., Ltd.	15705188088	admin@jheyou.com	CHINA	1268	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3991	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Nanjing jinheyou Trading Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58

View Lastest Price from Methyl 3-amino-4-hydroxybenzoate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-01	Methyl 3-amino-4-hydroxybenzoate 536-25-4		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2024-03-06	Methyl 3-Amino-4-hydroxybenzoate 536-25-4	$450.00	1g	98	500 Kg	R&D Scientific Inc.
2019-11-08	Methyl 3-amino-4-hydroxybenzoate 536-25-4		1g	98%min	20kg/month	Nanjing jinheyou Trading Co., Ltd.

Methyl 3-amino-4-hydroxybenzoate
536-25-4
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

Methyl 3-Amino-4-hydroxybenzoate
536-25-4
$450.00
98
R&D Scientific Inc.

Methyl 3-amino-4-hydroxybenzoate
536-25-4
$0.00
98%min
Nanjing jinheyou Trading Co., Ltd.

Methyl 3-amino-4-hydroxybenzoate Spectrum

Methyl 3-amino-4-hydroxybenzoate(536-25-4)¹HNMR

536-25-4(Methyl 3-amino-4-hydroxybenzoate)Related Search:

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Methyl acetate 4-Aminobenzoic acid 3-Hydroxybenzoic acid METHYL THIOPHENE-2-CARBOXYLATE Methylparaben

Kresoxim-methyl Methyl 3,5-dihydroxybenzoate Methyl benzoate 4-Hydroxybenzoic acid Thiophanate-methyl

Methyl Methyl 3-amino-4-ethoxybenzoate Benzoic acid, 3-amino-4-hydroxy-, methyl ester, hydrochloride

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ORTHOFORM ORTHOCAINE 3-Amino-4-hydroxybenzoic acid methyl ester 3-amino-4-hydroxy-benzoicacimethylester Aminobenz Methyl 4-hydroxy-3-aminobenzoate Methyl m-amino-p-hydroxybenzoate Orthoderm Orthoform new METHYL 3-AMINO-4-HYDROXYBENZENECARBOXYLATE METHYL 3-AMINO-4-HYDROXYBENZOATE Orthocain methyl 3-azanyl-4-hydroxy-benzoate Benzoic acid,3-aMino-4-hydroxy-, Methyl ester 2-Hydroxy-5-(methoxycarbonyl)aniline, 2-Amino-4-(methoxycarbonyl)phenol 1-Hydroxy-2-aMino-4-carboMethoxybenzene Mehyl3-aMino-4-hydroxybenzoate Methyl3-amino-4-hydroxybenzoate,95% NSC 9813 NSC9813 NSC-9813 Methy 3-amino-4-hydroxybenzoate 536-25-4 636-25-4 C6H3COOCH3OHNH2 Amines Aromatics Intermediates Miscellaneous Reagents Aromatic Esters Acids & Esters Anilines, Amides & Amines Phenols Esters Phenyls & Phenyl-Het