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2-AMINO-5-FLUOROPHENOL

2-AMINO-5-FLUOROPHENOL structure

CAS No.: 53981-24-1

Chemical Name:: 2-AMINO-5-FLUOROPHENOL

Synonyms: EOS-61433;2-AMINO-5-FLUOROPHEN;5-Fluoro-2-aMinophenol;2-AMINO-5-FLUOROPHENOL;2-azanyl-5-fluoro-phenol;4-Fluoro-2-hydroxyaniline;2-Amino-5-fluorophenol98%;Phenol, 2-amino-5-fluoro-;2- aMino-5-difluoro phenol;2-Amino-5-fluorophenol 98%

CBNumber:: CB2716633

Molecular Formula:: C6H6FNO

Molecular Weight:: 127.12

MDL Number:: MFCD00671759

MOL File:: 53981-24-1.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:52

Product description	Number	Pack Size	Price
2-Amino-5-fluorophenol >97.0%(GC)	A2300	1g	$38
2-Amino-5-fluorophenol >97.0%(GC)	A2300	5g	$110
2-Amino-5-fluorophenol	A609600	1g	$45
2-Amino-5-fluorophenol	A609600	5g	$50
2-Amino-5-fluorophenol	002246	1g	$319
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2-AMINO-5-FLUOROPHENOL Properties

Melting point	38°C
Boiling point	246.1±25.0 °C(Predicted)
Density	1.347±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO, Methanol
form	Solid
pka	8.76±0.10(Predicted)
color	Dark Beige
Water Solubility	Slightly soluble in water.
Sensitive	Air Sensitive
InChI	InChI=1S/C6H6FNO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2
InChIKey	IIDUNAVOCYMUFB-UHFFFAOYSA-N
SMILES	C1(O)=CC(F)=CC=C1N
CAS DataBase Reference	53981-24-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H315-H319-H335

Precautionary statements

P280h-P305+P351+P338-P312

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36/37/39

HazardClass

IRRITANT

HS Code

29089990

NFPA 704

	0
2		0

2-AMINO-5-FLUOROPHENOL price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A2300	2-Amino-5-fluorophenol >97.0%(GC)	53981-24-1	1g	$38	2025-07-31	Buy
TCI Chemical	A2300	2-Amino-5-fluorophenol >97.0%(GC)	53981-24-1	5g	$110	2025-07-31	Buy
TRC	A609600	2-Amino-5-fluorophenol	53981-24-1	1g	$45	2021-12-16	Buy
TRC	A609600	2-Amino-5-fluorophenol	53981-24-1	5g	$50	2021-12-16	Buy
Usbiological	002246	2-Amino-5-fluorophenol	53981-24-1	1g	$319	2021-12-16	Buy

Product number	Packaging	Price	Buy
A2300	1g	$38	Buy
A2300	5g	$110	Buy
A609600	1g	$45	Buy
A609600	5g	$50	Buy
002246	1g	$319	Buy

2-AMINO-5-FLUOROPHENOL Chemical Properties,Uses,Production

Chemical Properties

Dark Beige Solid

Uses

2-Amino-5-fluorophenol is a fluoroaniline metabolite. 2-Amino-5-fluorophenol is used as organic intermediate. To synthesize the intermediate (2-amino-5-fluorophenol-N, N, O-triacetic acid trimethyl ester) of indicator which used in the determination Mg2+ by NMR, three feasible reactions were experimentally carried out, such as alkaline hydrolysis, catalytic hydrogenation and esterification.

Synthesis

446-36-6

53981-24-1

The general procedure for the synthesis of 2-amino-5-fluorophenol from 5-fluoro-2-nitrophenol is as follows: 5-fluoro-2-nitrophenol (2.50 g, 15.9 mmol, commercially available from e.g., Aldrich) was dissolved in ethanol (50 ml), and 10% palladium-carbon catalyst (980 mg) was added for the hydrogenation reaction, which lasted for 1.5 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. The solid residue obtained was dissolved in ether, followed by addition of an equal volume of cyclohexane. The ether was removed by vacuum distillation at room temperature to give a light gray solid product. The product was filtered and washed with cyclohexane to give 2-amino-5-fluorophenol (1.90 g, 94% yield). Elemental analysis measured values: C, 56.4; H, 4.8; N, 10.9. theoretical values (C6H6FNO): C, 56.7; H, 4.8; N, 11.0%.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9742 - 9753
[2] Patent: WO2010/94643, 2010, A1. Location in patent: Page/Page column 46
[3] Patent: US5238908, 1993, A
[4] Patent: US5393735, 1995, A
[5] Chemistry - A European Journal, 2011, vol. 17, # 33, p. 9076 - 9082

2-AMINO-5-FLUOROPHENOL Preparation Products And Raw materials

Raw materials

5-Fluoro-2-nitrophenol Hydrogen Ethanol

Preparation Products

2-AMINO-5-FLUOROPHENOL Suppliers

Global( 272)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	9983	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
TargetMol Chemicals Inc.	58

View Lastest Price from 2-AMINO-5-FLUOROPHENOL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-01-05	2-AMINO-5-FLUOROPHENOL 53981-24-1	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
	2019-07-06	2-AMINO-5-FLUOROPHENOL 53981-24-1	US $1.00 / KG	1KG	99%	Customized	Career Henan Chemical Co

2-AMINO-5-FLUOROPHENOL
53981-24-1
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-AMINO-5-FLUOROPHENOL
53981-24-1
US $1.00 / KG
99%
Career Henan Chemical Co

2-AMINO-5-FLUOROPHENOL Spectrum

2-AMINO-5-FLUOROPHENOL(53981-24-1)¹HNMR 2-AMINO-5-FLUOROPHENOL(53981-24-1)¹⁹FNMR 2-AMINO-5-FLUOROPHENOL(53981-24-1)FT-IR

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2-AMINO-5-FLUOROPHENOL 2-Amino-5-fluorophenol 98% 2-Amino-5-fluorophenol98% 2-Amino-5-fluorophenol 97+% 2-azanyl-5-fluoro-phenol 2-Amino-5-fluorophenol ,90% 2-AMINO-5-FLUOROPHEN 4-Fluoro-2-hydroxyaniline (4-Fluoro-2-hydroxyphenyl)aMine 5-Fluoro-2-aMinophenol 2- aMino-5-difluoro phenol EOS-61433 2-Amino-5-fluorophenol > Phenol, 2-amino-5-fluoro- 2-AMINO-5-FLUOROPHENOL ISO 9001：2015 REACH 53981-24-1 2-AMINO-5-FLUOROPHENOL 2-Amino-5-Fluorophenol, 10 mM in DMSO 53981-24-1 Aromatic Phenols Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals Phenol&Thiophenol&Mercaptan Amines Aromatics Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals