BACE-1
- CAS No.
- 158736-49-3
- Chemical Name:
- BACE-1
- Synonyms
- ASP-2;BACE-1;HSPC104;MEMAPSIN-2;B-SECRETASE;HUMAN BACE-1;β-Secretase human;HUMAN BETA-SECRETASE;BETA-SECRETASE HUMAN;BETA-SECRETASE ENZYME
- CBNumber:
- CB2730309
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03702801
- MOL File:
- Mol file
BACE-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S4195 | β-Secretase human recombinant, expressed in HEK 293 cells (C-terminal FLAG tagged), ≥10,000 units/mg protei | 50 μg | $371.05 | 2025-07-31 | Buy | |
| Sigma-Aldrich | S4195 | β-Secretase human recombinant, expressed in HEK 293 cells (C-terminal FLAG tagged), extracellular domain, ≥10,000?units/mg protein, ≥90% (SDS-PAGE), buffered aqueous solution | 158736-49-3 | 50μG | $373 | 2023-06-20 | Buy |
| Sigma-Aldrich | SAB2900193 | Anti-BACE1 (AB1) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution | 158736-49-3 | 50μg | $599 | 2022-05-15 | Buy |
| Usbiological | 556167 | BACE1 PurifiedbyProteinGaffinitychromatography. | 50ug | $509 | 2026-06-03 | Buy | |
| Usbiological | 556167 | BACE1 PurifiedbyProteinGaffinitychromatography. | 100ug | $708 | 2026-06-03 | Buy |
BACE-1 Chemical Properties, Uses, Production
Uses
Human β-secretase or BACE1 has been used to study the binding reaction between amyloid precursor protein and β-secretase. It has also been used in BACE1 assay.
Biochem/physiol Actions
BACE1 (β-site APP-cleaving enzyme 1) is a transmembrane aspartyl protease responsible for cleaving the amyloid precursor protein (APP). BACE1-mediated cleavage of amyloid precursor protein (APP) is the first step during the generation of pathogenic amyloid-β peptides, hence making it the major drug target for Alzheimer′s disease (AD). Increased levels of enzymatic activity of BACE1 was found in cerebrospinal fluid from patients having both mild cognitive impairment (MCI) and AD, thereby suggesting the importance of BACE1 enzymatic activity in conversion of MCI to AD.
BACE-1 Preparation Products And Raw materials
Raw materials
Preparation Products
BACE-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| ACROBiosystems | 13121935750 | jiaxin.zhao@acrobiosystems.com | China | 1592 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 8165 | 58 |
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
