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8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE structure

CAS No.: 13185-18-7

Chemical Name:: 8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE

Synonyms: 8-METHOXY-1-TETRALONE;8-METHOXY-A-TETRALONE;8-Methoxy-α-Tetralone;3,4-Dihydro-8-methoxynaphthalen-1(2H);8-Methoxy-3,4-dihydronaphthalen-1-one;3,4-Dihydro-8-methoxy-1(2H)-naphthalenone;8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE;8-methoxy-3,4-dihydro-2H-naphthalen-1-one;1(2H)-Naphthalenone, 3,4-dihydro-8-Methoxy-;8-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one

CBNumber:: CB2730985

Molecular Formula:: C11H12O2

Molecular Weight:: 176.21

MDL Number:: MFCD01546945

MOL File:: 13185-18-7.mol

MSDS File:: SDS

Last updated:2026-05-20 15:44:50

Product description	Number	Pack Size	Price
8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE 95%	SC4141	0.25G	$173
8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE 95%	SC4141	1G	$342
8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE 95%	SC4141	5G	$987
3,4-Dihydro-8-methoxynaphthalen-1(2H)-one	074573	250.00mg	$389
3,4-Dihydro-8-methoxynaphthalen-1(2H)-one	074573	1.00g	$838
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8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE Properties

Melting point	128-130℃
Boiling point	325℃
Density	1.124
Flash point	155℃
storage temp.	Sealed in dry,Room Temperature
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HazardClass	IRRITANT

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	SC4141	8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE 95%	13185-18-7	0.25G	$173	2026-04-30	Buy
AstaTech	SC4141	8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE 95%	13185-18-7	1G	$342	2026-04-30	Buy
AstaTech	SC4141	8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE 95%	13185-18-7	5G	$987	2026-04-30	Buy
Matrix Scientific	074573	3,4-Dihydro-8-methoxynaphthalen-1(2H)-one	13185-18-7	250.00mg	$389	2026-05-18	Buy
Matrix Scientific	074573	3,4-Dihydro-8-methoxynaphthalen-1(2H)-one	13185-18-7	1.00g	$838	2026-05-18	Buy

Product number	Packaging	Price	Buy
SC4141	0.25G	$173	Buy
SC4141	1G	$342	Buy
SC4141	5G	$987	Buy
074573	250.00mg	$389	Buy
074573	1.00g	$838	Buy

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE Chemical Properties,Uses,Production

Uses

8-Methoxy-A-tetrahydronaphthone is an organic intermediate, and some literature reports its use in the preparation of RORγ modulators.

Synthesis

5-broMo-8-Methoxy-3,4-dihydronaphthalen-1(2H)-one

77259-96-2

13185-18-7

General procedure: In a 10 mL round-bottomed flask equipped with a magnetic stirrer, 5-bromo-8-methoxy-3,4-dihydronaphthalen-1(2H)-one (82 mg, 0.32 mmol), anhydrous methanol (4 mL), and triethylamine (1 drop) were added sequentially. Subsequently, a palladium/carbon catalyst (8 mg, 0.032 mmol) was added to the reaction system and the air within the reaction system was replaced with nitrogen. A hydrogen balloon was connected to the reaction system and the reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with methanol (3 x 10 mL). The filtrate was concentrated under reduced pressure and the resulting crude product was purified by column chromatography (silica gel as stationary phase and hexane-ethyl acetate = 9:1 as eluent) to afford the brown oily target product 8-methoxy-α-tetralone (54 mg, 96% yield). The product characterization data were as follows: IR (ATR, cm-1): 2943, 1677, 1563, 1280, 1067. 1H NMR (300 MHz, CDCl3): δ 7.39 (dd, J = 8.0 Hz, 1H, H-6), 6.79 (d, J = 8.0 Hz, 1H, H-7), 6.70 (d, J = 8.0 Hz. 1H, H-5), 3.84 (s, 3H, OMe), 2.93 (dd, J = 6.3 Hz, 2H, H-4), 2.69 (dd, J = 6.3 Hz, 2H, H-2), 2.10 (dd, J = 6.3 Hz, 2H, H-3).13C NMR (75 MHz, CDCl3): δ 197.5 (C-1), 160.0 (C-8), 2.10 (C-8), 2.10 (C-8), 1.0 (C-8), 1.0 (C-8), 1.0 (C-8), 1.0 (C-8), 2.10 (C-8) 160.0 (C-8), 146.8 (C-10), 135.4 (C-6), 123.6 (C-9), 121.1 (C-5), 110.2 (C-7), 55.9 (OMe), 40.7 (C-2), 31.5 (C-4), 22.1 (C-3). Mass spectrum (MS): m/z (%) = 176 (100) [M+], 91 (28), 77 (40). High Resolution Mass Spectrometry (HRMS, ESI): m/z [M+H]+ Calculated value C11H12O2: 177.0910; measured value: 177.0910.

References

[1] Organic Preparations and Procedures International, 2010, vol. 42, # 5, p. 499 - 502
[2] Synthesis (Germany), 2016, vol. 48, # 13, p. 2050 - 2056
[3] Tetrahedron, 1980, vol. 36, # 17, p. 2513 - 2519

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE Preparation Products And Raw materials

Raw materials

3,4-Dihydro-8-hydroxynaphthalen-1(2H)-one 5-broMo-8-Methoxy-3,4-dihydronaphthalen-1(2H)-one Iodomethane Methanol Activated carbon

Hydrogen Palladium

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Preparation Products

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE Suppliers

Global( 122)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Shanghai Rlavie Technology Co ltd	+86-021-67759270 +8617717059219	sales@rlavie.com	China	1030	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
Henan Alfa Chemical Co., Ltd	+8615838112936	sale03@alfachem.cn	China	9733	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Biochempartner	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Shanghai Rlavie Technology Co ltd	58
Hefei Hirisun Pharmatech Co., Ltd	58
CD Chemical Group Limited	58
Henan Alfa Chemical Co., Ltd	58

View Lastest Price from 8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	8-methoxy-1-tetralone 13185-18-7	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2022-01-04	8-methoxy-3,4-dihydro-2H-naphthalen-1-one 13185-18-7	US $0.00-0.00 / KG	1g	98%min	20kgs/month	Shanghai Rlavie Technology Co ltd
2019-07-06	8-methoxy-1-tetralone 13185-18-7	US $1.00 / KG	1KG	98%	500kg	Career Henan Chemical Co

8-methoxy-1-tetralone
13185-18-7
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

8-methoxy-3,4-dihydro-2H-naphthalen-1-one
13185-18-7
US $0.00-0.00 / KG
98%min
Shanghai Rlavie Technology Co ltd

8-methoxy-1-tetralone
13185-18-7
US $1.00 / KG
98%
Career Henan Chemical Co

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE Spectrum

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(13185-18-7)¹HNMR

13185-18-7(8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE)Related Search:

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8-Methoxy-α-Tetralone 8-METHOXY-A-TETRALONE 8-METHOXY-1-TETRALONE 8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE 3,4-Dihydro-8-methoxy-1(2H)-naphthalenone 8-Methoxy-3,4-dihydronaphthalen-1-one 1(2H)-Naphthalenone, 3,4-dihydro-8-Methoxy- 8-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one 3,4-Dihydro-8-methoxynaphthalen-1(2H) 8-methoxy-3,4-dihydro-2H-naphthalen-1-one 13185-18-7