6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
- CAS No.
- 34334-69-5
- Chemical Name:
- 6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
- Synonyms
- CIRSILIOL;Crisiliol;Cirsiliol - Bio-X ?;Cirsiliol >=95% (HPLC);3'-Hydroxy-6-methoxygenkwanin;3',4',5-Trihydroxy-6,7-dimethoxy;6-Methoxyluteolin 7-methyl ether;6-Hydroxyluteolin-6,7-dimethyl ether;6,7-DIMETHOXY-5,3',4'-TRIHYDROXYFLAVONE;6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
- CBNumber:
- CB2736583
- Molecular Formula:
- C17H14O7
- Molecular Weight:
- 330.29
- MDL Number:
- MFCD00210577
- MOL File:
- 34334-69-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Cirsiliol ≥95% (HPLC) | SML0953 | 5mg | $103 |
| Cirsiliol ≥95% (HPLC) | SML0953 | 25mg | $417 |
| 6,7-Dimethoxy-3'',4'',5-trihydroxyflavone | D476383 | 1mg | $60 |
| 6,7-Dimethoxy-3',4',5-trihydroxyflavone | FD66719 | 5mg | $75 |
| 6,7-Dimethoxy-3',4',5-trihydroxyflavone | FD66719 | 10mg | $100 |
| Melting point | 280-281.5℃ (methanol ) |
|---|---|
| Boiling point | 616.1±55.0 °C(Predicted) |
| Density | 1.483±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Acetone: soluble; Chloroform: soluble; DMSO: soluble |
| form | powder |
| pka | 6.31±0.40(Predicted) |
| color | white to beige |
| FDA UNII | 8W4Y5JK3XE |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | DJ3011100 |
6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0953 | Cirsiliol ≥95% (HPLC) | 34334-69-5 | 5mg | $103 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0953 | Cirsiliol ≥95% (HPLC) | 34334-69-5 | 25mg | $417 | 2025-07-31 | Buy |
| TRC | D476383 | 6,7-Dimethoxy-3'',4'',5-trihydroxyflavone | 34334-69-5 | 1mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD66719 | 6,7-Dimethoxy-3',4',5-trihydroxyflavone | 34334-69-5 | 5mg | $75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD66719 | 6,7-Dimethoxy-3',4',5-trihydroxyflavone | 34334-69-5 | 10mg | $100 | 2021-12-16 | Buy |
6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Chemical Properties,Uses,Production
Uses
Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.
Definition
ChEBI: A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5, 3' and 4' respectively.
Biological Activity
Cirsiliol is a flavonoid th at displays anti-inflammatory, anti-oxidant, anti-proliferative, and anti-bacterial activities. Cirsiliol sensitizes non-small cell lung cancer cell lines (NSCLC) to radiation therapy. Cirsiliol inhibits epithelial-mesenchymal transition likely by induction of tumor-suppressive miR-34a, which suppresses Notch-1 expression NSCLC.
in vivo
In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone[2].
IC 50
5-Lipoxygenase
References
[1] Mustafa EH, et al. Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum. Gen Pharmacol. 1992 May;23(3):555-60. DOI:10.1016/0306-3623(92)90127-6
[2] Kang J, et al. Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. J Biol Chem. 2013 Sep 20;288(38):27343-57. DOI:10.1074/jbc.M113.490482
6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Preparation Products And Raw materials
6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39032 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Mensura Group Limited | +8618109034517 | 1058503172@qq.com | China | 2900 | 58 |
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