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2-Chloro-4-nitropyridine

2-Chloro-4-nitropyridine Structure
2-Chloro-4-nitropyridine structure
CAS No.
23056-36-2
Chemical Name:
2-Chloro-4-nitropyridine
Synonyms
4-Nitro-2-chloropyridine;2-Chl;AURORA 23245;AKOS BBS-00001358;2-Chloro-4-nitropyri;OTAVA-BB BB7017520053;2-chloro-4-nitropyrine;2-Choro-4-nitropyridine;2-CHLORO-4-NITROPYRIDINE;oro-4-nitropyridine, 98%
CBNumber:
CB2737111
Molecular Formula:
C5H3ClN2O2
Molecular Weight:
158.54
MDL Number:
MFCD00661454
MOL File:
23056-36-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:44:26
Product description Number Pack Size Price
2-Chloro-4-nitropyridine 97% 557390 5g $60.4
2-Chloro-4-nitropyridine 97% 557390 1g $25
2-Chloro-4-nitropyridine >98.0%(GC) C2283 1g $37
2-Chloro-4-nitropyridine >98.0%(GC) C2283 5g $101
2-Chloro-4-nitropyridine Asreported 267573 5g $369
More product size
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2-Chloro-4-nitropyridine Properties

Melting point 52-56 °C (lit.)
Boiling point 258.4±20.0 °C(Predicted)
Density 1.489±0.06 g/cm3(Predicted)
Flash point 223 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka -1.93±0.10(Predicted)
form crystalline powder
color Yellow
BRN 120418
InChI InChI=1S/C5H3ClN2O2/c6-5-3-4(8(9)10)1-2-7-5/h1-3H
InChIKey LIEPVGBDUYKPLC-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC([N+]([O-])=O)=C1
CAS DataBase Reference 23056-36-2(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36
WGK Germany  3
HazardClass  IRRITANT
PackingGroup  III
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Chloro-4-nitropyridine price More Price(106)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 557390 2-Chloro-4-nitropyridine 97% 23056-36-2 5g $60.4 2026-04-30 Buy
Sigma-Aldrich 557390 2-Chloro-4-nitropyridine 97% 23056-36-2 1g $25 2023-06-20 Buy
TCI Chemical C2283 2-Chloro-4-nitropyridine >98.0%(GC) 23056-36-2 1g $37 2026-04-30 Buy
TCI Chemical C2283 2-Chloro-4-nitropyridine >98.0%(GC) 23056-36-2 5g $101 2026-04-30 Buy
Usbiological 267573 2-Chloro-4-nitropyridine Asreported 23056-36-2 5g $369 2026-06-03 Buy
Product number Packaging Price Buy
557390 5g $60.4 Buy
557390 1g $25 Buy
C2283 1g $37 Buy
C2283 5g $101 Buy
267573 5g $369 Buy

2-Chloro-4-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

Light yellow powder

Uses

2-Chloro-4-nitropyridine is used in the preparation of (thio)barbituric acid derivatives in the treatment of obesity related non-alcoholic fatty liver disease. As well it is used in the production of selective and potent MET Kinase inhibitors.

Uses

2-Chloro-4-nitropyridine may be used to synthesize 2-chloro-4-ethoxypyridine and 4-thiophenoxypyridines.

Synthesis

2-Chloro-4-nitropyridine 1-oxide

14432-16-7

2-Chloro-4-nitropyridine

23056-36-2

The general procedure for the synthesis of 2-chloro-4-nitropyridine-N-oxide from 2-chloro-4-nitropyridine-N-oxide is as follows: referring to the method of Example 17, phosphorus trichloride (4.2 mL, 48.7 mmol) was slowly added to a solution of anhydrous chloroform (25 mL) of 2-chloro-4-nitropyridine-N-oxide (1.70 g, 9.74 mmol) at room temperature. Subsequently, the reaction mixture was heated to reflux and maintained at this temperature for the reaction overnight. Upon completion of the reaction, the mixture was cooled to room temperature. The reaction solution was carefully poured into ice water and the pH was adjusted to 7-8 with alkali and subsequently washed with saturated sodium bicarbonate solution. The aqueous phase was extracted twice with chloroform, all organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and the organic phase was concentrated. Finally, the product was dried under high vacuum to give 2-chloro-4-nitropyridine (1.2 g, 78% yield) as a solid.

References

[1] Journal of Organic Chemistry, 2009, vol. 74, # 19, p. 7441 - 7448
[2] Patent: WO2008/62182, 2008, A1. Location in patent: Page/Page column 114
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 2674

2-Chloro-4-nitropyridine synthesis

14432-16-7
23056-36-2
Synthesis of 2-Chloro-4-nitropyridine from 2-Chloro-4-nitropyridine 1-oxide

2-Chloro-4-nitropyridine Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Phosphorus oxitrichloride Nitric acid Acetic acid Sulfuric acid
2-Chloropyridine 4-Nitropyridine N-oxide Phosphorus trichloride 2-Chloro-4-nitropyridine 1-oxide 2-Chloropyridine-N-oxide

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Preparation Products

2-Chloro-4-hydroxypyridine 4-Bromo-2-methylpyridine 4-Nitro-2-phenylpyridine

2-Chloro-4-nitropyridine Suppliers

Global( 436)Suppliers
Supplier Tel Email Country ProdList Advantage
Anhui Ruihan Technology Co., Ltd 		+undefined17756083858 daisy@anhuiruihan.com China 973 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
HaBo Hong Kong Co., Limited. 		+86-25-18512596065 info@habotech.com CHINA 933 58
BTC Nantong Pharmaceuticals Technology Co.,Ltd 		+86-0513-81283365 Info@btcpharm.com China 251 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
Supplier Advantage
Anhui Ruihan Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
HaBo Hong Kong Co., Limited. 		58
BTC Nantong Pharmaceuticals Technology Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from 2-Chloro-4-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-nitropyridine pictures 2025-11-18 2-Chloro-4-nitropyridine
23056-36-2
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Chloro-4-nitropyridine pictures 2025-04-04 2-Chloro-4-nitropyridine
23056-36-2
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-Chloro-4-nitropyridine pictures 2024-02-26 2-Chloro-4-nitropyridine
23056-36-2
 1kg 98% BTC Nantong Pharmaceuticals Technology Co.,Ltd

2-Chloro-4-nitropyridine Spectrum

2-Chloro-4-nitropyridine(23056-36-2)1HNMR2-Chloro-4-nitropyridine(23056-36-2)IR

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OTAVA-BB BB7017520053 2-CHLORO-4-NITROPYRIDINE (2-CHLOROPYRIDIN-4-YL)(HYDROXY)OXOAMMONIUM AURORA 23245 AKOS BBS-00001358 2-chloro-4-nitropyrine 2-Chloro-4-nitropyridine ,98% 2-Chloro-4-nitropyri JRH-09201, 2-Chloro-4-nitropyridine, 97% 2-Choro-4-nitropyridine 2-Chl 2-Chloro-4-nitropyridine > oro-4-nitropyridine, 98% Pyridine, 2-chloro-4-nitro- 2,5-Difluoro-6-iodopyridine 2-Chloro-4-nitropyridine ISO 9001：2015 REACH 4-Nitro-2-chloropyridine 23056-36-2 Building Blocks Pyridines Heterocyclic Building Blocks Halogenated Heterocycles pyridine series C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Pyridine Derivertives Pyridine