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tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate structure

CAS No.: 214834-18-1

Chemical Name:: tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate

Synonyms: BUTTPARK 146\06-96;1-Boc-4-thiocarbamoylpiperidine;N-Boc-4-PiperidinecarbothioaMide;N-BOC-piperidine-4-carbothioamide;1-Boc-piperidine-4-carbothioamide;N-BOC-Piperidine-4-thiocarboxamide;N1-BOC-PIPERIDINE-4-THIOCARBOXAMIDE;4-Carbamothioylpiperidine, N1-BOC protected;PIPERIDINE-4-THIOCARBOXAMIDE, 1-BOC PROTECTED;Piperidine-4-thiocarboxamide, N1-BOC protected

CBNumber:: CB2748762

Molecular Formula:: C11H20N2O2S

Molecular Weight:: 244.35

MDL Number:: MFCD02180954

MOL File:: 214834-18-1.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:46

Product description	Number	Pack Size	Price
4-Carbamothioylpiperidine,N1-BOCprotected 95%	OR8046	1g	$18
1-Boc-4-Thiocarbamoylpiperidine	X4353	1g	$25
1-N-Boc-piperidine-4-thiocarboxamide	FB53494	1g	$45
4-Carbamothioylpiperidine,N1-BOCprotected 95%	OR8046	5g	$76
1-N-Boc-piperidine-4-thiocarboxamide	FB53494	2g	$85
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tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Properties

Melting point	130 °C
Boiling point	356.0±52.0 °C(Predicted)
Density	1.158±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	13.03±0.20(Predicted)
form	solid
color	White

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H351b-H372
Precautionary statements	P201-P202-P260-P264b-P270-P272-P280g-P302+P352-P308+P313-P363-P403-P501c
Hazard Codes	Xi,Xn,N
Risk Statements	20/21/22-36/37/38-22-50
Safety Statements	26-36/37/39-22-61
Hazard Note	Irritant
HS Code	2933399990

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR8046	4-Carbamothioylpiperidine,N1-BOCprotected 95%	214834-18-1	1g	$18	2021-12-16	Buy
AK Scientific	X4353	1-Boc-4-Thiocarbamoylpiperidine	214834-18-1	1g	$25	2021-12-16	Buy
Biosynth Carbosynth	FB53494	1-N-Boc-piperidine-4-thiocarboxamide	214834-18-1	1g	$45	2021-12-16	Buy
Apolloscientific	OR8046	4-Carbamothioylpiperidine,N1-BOCprotected 95%	214834-18-1	5g	$76	2021-12-16	Buy
Biosynth Carbosynth	FB53494	1-N-Boc-piperidine-4-thiocarboxamide	214834-18-1	2g	$85	2021-12-16	Buy

Product number	Packaging	Price	Buy
OR8046	1g	$18	Buy
X4353	1g	$25	Buy
FB53494	1g	$45	Buy
OR8046	5g	$76	Buy
FB53494	2g	$85	Buy

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Chemical Properties,Uses,Production

Synthesis

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE

91419-48-6

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate

214834-18-1

General procedure for the synthesis of tert-butyl 4-aminothiocarbonyltetrahydropyridine-1(2H)-carboxylate from tert-butyl 4-carbamoylpiperidine-1-carboxylate: tert-butyl 4-carbamoylpiperidine-1-carboxylate (2.65 g, 11.62 mmol) was dissolved in a solvent mixture of DME/DCM (2:1, 78 mL), followed by addition of Lawesson reagent (2.35 g, 5.81 mmol, 0.5 equiv). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate and washed with saturated aqueous K2CO3 solution. The organic layer was separated, dried with anhydrous Na2SO4, filtered and concentrated to dryness. The obtained residue was ground with ether and dried to give tert-butyl 4-aminothiocarbonyltetrahydropyridine-1(2H)-carboxylate (2.65 g, 92% yield) as a white solid. The product was analyzed by HPLC showing a retention time (Rt) of 5.06 min. 1H NMR (401 MHz, DMSO-d6) δ ppm: 9.39 (br.s., 1H), 9.09 (br.s., 1H), 4.00 (d, J=12.6 Hz, 2H), 2.77-2.61 (m, 3H), 1.71-1.51 (m , 4H), 1.39 (br.s., 9H).

References

[1] Patent: WO2012/113774, 2012, A1. Location in patent: Page/Page column 40
[2] Patent: US2013/324551, 2013, A1. Location in patent: Paragraph 0311; 0312; 0313
[3] Patent: WO2011/153435, 2011, A1. Location in patent: Page/Page column 13-14
[4] Patent: US2011/318418, 2011, A1. Location in patent: Page/Page column 12
[5] Patent: WO2016/30443, 2016, A1. Location in patent: Page/Page column 102

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Preparation Products And Raw materials

Raw materials

1-Boc-4-cyanopiperidine TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Di-tert-butyl dicarbonate Isonipecotamide Lawesson's Reagent

Dichloromethane 1,2-Dimethoxyethane

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Preparation Products

Piperidine, 4-[4-(2-methoxyphenyl)-2-thiazolyl]- 4-(dimethyl-1,3-thiazol-2-yl)piperidine

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Antai Fine Chemical Technology Co.,Limited	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-10-13	tert-Butyl 4-carbamothioylpiperidine-1-carboxylate 214834-18-1	US $3.90-5.90 / KG	1KG	99%	g-kg-tons, free sample is available	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2019-12-25	tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate 214834-18-1	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1
US $3.90-5.90 / KG
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate
214834-18-1
US $1.00 / KG
99%
Career Henan Chemical Co

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Spectrum

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate(214834-18-1)¹HNMR

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BUTTPARK 146\06-96 PIPERIDINE-4-THIOCARBOXAMIDE, 1-BOC PROTECTED TERT-BUTYL 4-(AMINOCARBOTHIOYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Piperidine-4-thiocarboxamide, N1-BOC protected Piperidine-4-thiocarboxamide, N1-BOC protected 97% N1-BOC-PIPERIDINE-4-THIOCARBOXAMIDE 1-tert-Butoxycarbonylpiperidine-4-carbothioamide tert-butyl 4-(aminocarbothioyl)tetrahydropyridine- tert-butyl 4-thiocarbamoylpiperidine-1-carboxylate N-BOC-piperidine-4-carbothioamide tert-butyl 4-(aminocarbonothioyl)piperidine-1-carboxylate N-Boc-4-PiperidinecarbothioaMide 4-Carbamothioylpiperidine, N1-BOC protected 97% tert-Butyl 4-carbamothioylpiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-carbamothioylpiperidine, 1-(tert-Butoxycarbonyl)piperidine-4-thiocarboxamide 1-Piperidinecarboxylicacid,4-(aMinothioxoMethyl)-,1,1-diMethylethylester tert-Butyl 4-(aMinocarbothioyl)-tetrahydropyridin-1(2H)--carboxylate 4-(4-phenylthiazol-2-yl)piperidine-1-carboxylic acid tert-butyl ester 1-Boc-4-thiocarbamoylpiperidine N-BOC-Piperidine-4-thiocarboxamide 4-(4-phenylthiazol-2-yl)piperidine-1-carboxylic acid tert-butyl 1-Boc-piperidine-4-carbothioamide tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carb... 4-Carbamothioylpiperidine, N1-BOC protected 214834-18-1 C11H20N2O2S Pyrans, Piperidines &Piperazines Pyrans, Piperidines & Piperazines