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4,6-Dichloroquinazoline

4,6-Dichloroquinazoline structure

CAS No.: 7253-22-7

Chemical Name:: 4,6-Dichloroquinazoline

Synonyms: 6-dichloroquinazoline;4,6-DICHLOROQUINAZOLINE;Quinazoline, 4,6-dichloro-

CBNumber:: CB2759151

Molecular Formula:: C8H4Cl2N2

Molecular Weight:: 199.04

MDL Number:: MFCD00089492

MOL File:: 7253-22-7.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:54

Product description	Number	Pack Size	Price
4,6-DICHLOROQUINAZOLINE Aldrich^CPR	S658367	1 unit	$113
4,6-DICHLOROQUINAZOLINE AldrichCPR	S658367	25MG	$110
4,6-Dichloroquinazoline	D438490	10mg	$45
4,6-Dichloroquinazoline	D438490	50mg	$60
4,6-Dichloroquinazoline 95+%	072010	1g	$76
More product size

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4,6-Dichloroquinazoline Properties

Melting point	155-156 °C
Boiling point	305.7±22.0 °C(Predicted)
Density	1.486±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	0.11±0.30(Predicted)
Appearance	Off-white to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS06
Signal word	Danger
Hazard statements	H301-H315-H318-H335
Precautionary statements	P261-P280-P301+P310-P305+P351+P338
HS Code	2933998090

4,6-Dichloroquinazoline price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S658367	4,6-DICHLOROQUINAZOLINE Aldrich^CPR	7253-22-7	1 unit	$113	2025-07-31	Buy
Sigma-Aldrich	S658367	4,6-DICHLOROQUINAZOLINE AldrichCPR	7253-22-7	25MG	$110	2024-03-01	Buy
TRC	D438490	4,6-Dichloroquinazoline	7253-22-7	10mg	$45	2021-12-16	Buy
TRC	D438490	4,6-Dichloroquinazoline	7253-22-7	50mg	$60	2021-12-16	Buy
Matrix Scientific	072010	4,6-Dichloroquinazoline 95+%	7253-22-7	1g	$76	2021-12-16	Buy

Product number	Packaging	Price	Buy
S658367	1 unit	$113	Buy
S658367	25MG	$110	Buy
D438490	10mg	$45	Buy
D438490	50mg	$60	Buy
072010	1g	$76	Buy

4,6-Dichloroquinazoline Chemical Properties,Uses,Production

Synthesis

16064-14-5

7253-22-7

General procedure for the synthesis of 4,6-dichloroquinazoline from 6-chloroquinazolin-4-one: 6-chloroquinazolin-4-one (400 mg, 2.21 mmol, 1.0 eq.), phosphoryl chloride (1.99 mL, 21.4 mmol, 9.64 eq.) and triethylamine (0.99 mL, 7.11 mmol, 3.21 eq.) were mixed under nitrogen protection in a reaction flask. The reaction mixture was stirred and refluxed for 2.5 hours at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporation and the residue was recrystallized twice with toluene to give a brown solid. The solid was dissolved in dichloromethane (25 mL) and the organic phase was washed twice with saturated ammonium chloride solution (25 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated to give a brown solid. The crude product was purified by silica gel column chromatography with an eluent of 9:1 to 3:1 hexane/ethyl acetate to give 4,6-dichloroquinazoline (300 mg) as an off-white solid in 68% yield. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 9.16 (s, 1H), 8.33 (s, 1H), 8.17 (apparent t, 2H, J = 7 Hz).

References

[1] Patent: WO2015/164374, 2015, A1. Location in patent: Paragraph 00349; 00351
[2] Oriental Journal of Chemistry, 2010, vol. 26, # 4, p. 1401 - 1406
[3] Patent: US2005/54626, 2005, A1. Location in patent: Page/Page column 38
[4] Patent: WO2016/91774, 2016, A1. Location in patent: Page/Page column 21
[5] Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982, vol. 37, # 7, p. 907 - 911

4,6-Dichloroquinazoline Preparation Products And Raw materials

Raw materials

6-Chloro-4-hydroxyquinazoline

Preparation Products

4,6-Dichloroquinazoline Suppliers

Global( 119)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Henan Alfa Chemical Co., Ltd	+8615838112936	alfa10@alfachem.cn	China	12931	58
Nanjing Hengbei Chemicals Co., Ltd.	+86-25-58393656	sales@hengbeichem.cn	China	6854	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24727	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49975	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Alfa Chemical Co., Ltd	58
Nanjing Hengbei Chemicals Co., Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from 4,6-Dichloroquinazoline manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-05	4,6-Dichloroquinazoline 7253-22-7	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

4,6-Dichloroquinazoline
7253-22-7
US $1.00 / KG
99%
Career Henan Chemical Co

4,6-Dichloroquinazoline Spectrum

4,6-Dichloroquinazoline(7253-22-7)¹HNMR

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4,6-DICHLOROQUINAZOLINE 6-dichloroquinazoline Quinazoline, 4,6-dichloro- 7253-22-7 Halides Heterocycles