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3-(Trifluoromethyl)benzaldehyde

3-(Trifluoromethyl)benzaldehyde structure

CAS No.: 454-89-7

Chemical Name:: 3-(Trifluoromethyl)benzaldehyde

Synonyms: MTF-BAD;3-(three fluoroMethyl;Cinacalcet Impurity 56;3-TRIFLUORMETHYLBENZALDEHYDE;m-Trifuoromethylbenzaldehyde;M-TRIFLUOROMETHYLBENZALDEHYDE;3-TRIFLUOROMETHYLBENZYLDEHYDE;Alpha-Trifluoro-M-tolualdehyde;A,A,A-TRIFLUORO-3-TOLUALDEHYDE;A,A,A-TRIFLUORO-M-TOLUALDEHYDE

CBNumber:: CB2759919

Molecular Formula:: C8H5F3O

Molecular Weight:: 174.12

MDL Number:: MFCD00003373

MOL File:: 454-89-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-21 17:10:26

Product description	Number	Pack Size	Price
3-(Trifluoromethyl)benzaldehyde 97%	196878	5g	$67.9
3-(Trifluoromethyl)benzaldehyde 97%	196878	25g	$118
3-(Trifluoromethyl)benzaldehyde >95.0%(GC)	T1399	5g	$38
3-(Trifluoromethyl)benzaldehyde >95.0%(GC)	T1399	25g	$111
3-(Trifluoromethyl)benzaldehyde	T792200	25g	$65
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3-(Trifluoromethyl)benzaldehyde Properties

Boiling point	83-86 °C30 mm Hg(lit.)
Density	1.301 g/mL at 25 °C(lit.)
refractive index	n20/D 1.465(lit.)
Flash point	155 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Liquid
color	Clear colorless to very slightly orange
Specific Gravity	1.301
Sensitive	Air Sensitive
BRN	2327537
InChI	1S/C8H5F3O/c9-8(10,11)7-3-1-2-6(4-7)5-12/h1-5H
InChIKey	NMTUHPSKJJYGML-UHFFFAOYSA-N
SMILES	[H]C(=O)c1cccc(c1)C(F)(F)F
CAS DataBase Reference	454-89-7(CAS DataBase Reference)
FDA UNII	AT7H4H5U3E
NIST Chemistry Reference	Benzaldehyde, 3-(trifluoromethyl)-(454-89-7)
EPA Substance Registry System	Benzaldehyde, 3-(trifluoromethyl)- (454-89-7)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H315-H319-H335-H410

Precautionary statements

P261-P264-P271-P273-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)

WGK Germany

10-23

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29130000

Storage Class

10 - Combustible liquids

Hazard Classifications

Aquatic Acute 1
Aquatic Chronic 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

3-(Trifluoromethyl)benzaldehyde price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	196878	3-(Trifluoromethyl)benzaldehyde 97%	454-89-7	5g	$67.9	2026-03-19	Buy
Sigma-Aldrich	196878	3-(Trifluoromethyl)benzaldehyde 97%	454-89-7	25g	$118	2026-03-19	Buy
TCI Chemical	T1399	3-(Trifluoromethyl)benzaldehyde >95.0%(GC)	454-89-7	5g	$38	2026-03-19	Buy
TCI Chemical	T1399	3-(Trifluoromethyl)benzaldehyde >95.0%(GC)	454-89-7	25g	$111	2026-03-19	Buy
TRC	T792200	3-(Trifluoromethyl)benzaldehyde	454-89-7	25g	$65	2021-12-16	Buy

Product number	Packaging	Price	Buy
196878	5g	$67.9	Buy
196878	25g	$118	Buy
T1399	5g	$38	Buy
T1399	25g	$111	Buy
T792200	25g	$65	Buy

3-(Trifluoromethyl)benzaldehyde Chemical Properties,Uses,Production

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Chemical Properties

CLEAR COLOURLESS TO VERY SLIGHTLY ORANGE LIQUID

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-╬│-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 426, 1946 DOI: 10.1021/ja01207a024

General Description

Aldol reaction of 3-(trifluoromethyl)benzaldehyde with hydroxyacetone in the aldolase antibody 38C2-ionic liquid system has been investigated.

3-(Trifluoromethyl)benzaldehyde synthesis

Synthesis of 3-(Trifluoromethyl)benzaldehyde from 3-(Trifluoromethyl)benzyl alcohol

3-(Trifluoromethyl)benzaldehyde Preparation Products And Raw materials

Raw materials

1,3-Diphenyl-1,1,3,3-tetramethyldisiloxane

Preparation Products

3-(3-Trifluoromethylphenyl)propionic acid 3-(Trifluoromethyl)benzoyl chloride 3-(Trifluoromethyl)benzyl bromide 3-(3-(Trifluoromethyl)phenyl)propan-1-ol 3-(Trifluoromethyl)cinnamic acid

3,3'-BIS(TRIFLUOROMETHYL)BENZOPHENONE 3-（trifluoromethyl) Cinnamaldehyde 3-(TRIFLUOROMETHYL)BENZOYL FLUORIDE 3'-(TRIFLUOROMETHYL)PROPIOPHENONE 3-(Trifluoromethyl)benzylamine

3-(TRIFLUOROMETHYL)BENZALDOXIME

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3-(Trifluoromethyl)benzaldehyde Suppliers

Global( 508)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3590	58
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3996	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58

View Lastest Price from 3-(Trifluoromethyl)benzaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-24	3-(Trifluoromethyl)benzaldehyde 454-89-7	US $5.00 / kg	1kg	≥99%	200mt/year	Jinan Finer Chemical Co., Ltd
2026-04-21	3-(Trifluoromethyl)benzaldehyde 454-89-7	US $29.00 / g		97.55%	10g	TargetMol Chemicals Inc.
2026-03-20	3-(Trifluoromethyl)benzaldehyde 454-89-7	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd

3-(Trifluoromethyl)benzaldehyde
454-89-7
US $5.00 / kg
≥99%
Jinan Finer Chemical Co., Ltd

3-(Trifluoromethyl)benzaldehyde
454-89-7
US $29.00 / g
97.55%
TargetMol Chemicals Inc.

3-(Trifluoromethyl)benzaldehyde
454-89-7
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

3-(Trifluoromethyl)benzaldehyde Spectrum

3-(Trifluoromethyl)benzaldehyde(454-89-7)MS 3-(Trifluoromethyl)benzaldehyde(454-89-7)¹HNMR 3-(Trifluoromethyl)benzaldehyde(454-89-7)¹³CNMR 3-(Trifluoromethyl)benzaldehyde(454-89-7)IR1 3-(Trifluoromethyl)benzaldehyde(454-89-7)Raman

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m-Trifluoromethoxy benzaldehyde 3-Formylbenzotrifluoride, alpha,alpha,alpha-Trifluoro-3-tolualdehyde Alpha-Trifluoro-M-tolualdehyde 3-(TrifluoroMethyl)benzaldehyde, 97% 25GR 3-(TrifluoroMethyl)benzaldehyde, 97% 5GR 3-Formylbenzotrifluoride, alpha,alpha,alpha-Trifluoro-m-tolualdehyde 3-(three fluoroMethyl)benzeneforMaldehyde Between the three groups in benzene forMaldehyde alpha,alpha,alpha-Trifluoro-m-toluylaldehyde 3-TRIFLUORMETHYLBENZALDEHYDE 3-(TRIFLUOROMETHYL)BENZALDEHYDE A,A,A-TRIFLUORO-3-TOLUALDEHYDE A,A,A-TRIFLUORO-M-TOLUALDEHYDE alpha,alpha,alpha-Trifluoro-3-tolualdehyde ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUALDEHYDE Cinacalcet Impurity 56 BENZOTRIFLUORIDE-3-CARBALDEHYDE MTF-BAD M-TRIFLUOROMETHYLBENZALDEHYDE 3-(trifluoromethyl)-benzaldehyd m-Tolualdehyde, alpha,alpha,alpha-trifluoro- m-Trifluoromethylbenzaldehyde 3-Trifluoromethyl Benzaldehyde 3-TRIFLUOROMETHYLBENZYLDEHYDE m-Trifluoromethylbenzaldehyde,97% à,à,à-trifluoro-m-tolualdehyde 3-(Trifluoromethyl)benzaldehyde98% A,A,A-TRIFLUORO-META-TOLUALDEHYDE ALPHA,ALPHA,ALPHA-TRIFLUORO-META-TOLUALDEHYDE α,α,α-Trifluoro-m-toluylaldehyde m-Trifuoromethylbenzaldehyde Benzaldehyde, 3-(trifluoromethyl)- 3-(Trifluoromethyl)benzaldehyde,97% 3-(three fluoroMethyl 3-(Trifluorzomethyl)Benzaldehyde trifluoromethylbenzaldehyde-13C6 α,α,α-trifluoro-3-tolualdehyde 3-(Trifluoromethyl)benzaldehyde, 10 mM in DMSO 454-89-7 455-89-7 454-89-1 454-89-71 455-89-7 C8H5F3O ALDEHYDE Organic Building Blocks Aldehydes Building Blocks Carbonyl Compounds C8 Benzotrifluoride Series Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde 3-(Trifluoromethyl)benzaldehyde bc0001