ChemicalBook >> CAS DataBase List >>2-Chloro-5-(chloromethyl)pyridine

2-Chloro-5-(chloromethyl)pyridine

2-Chloro-5-(chloromethyl)pyridine structure

CAS No.: 70258-18-3

Chemical Name:: 2-Chloro-5-(chloromethyl)pyridine

Synonyms: 2-chloro-chloromethylpyridine;2-CHLORO-5-CHLOROMETHYLPYRIDINE;Pyridine, 2-chloro-5-(chloromethyl)-;6-Chlo;60% in DMF;AKOS MSC-0759;AURORA KA-6694;2-Chloro-5-(ch;TIMTEC-BB SBB003948;2-Chloro-5-Chloro-Me

CBNumber:: CB2761158

Molecular Formula:: C6H5Cl2N

Molecular Weight:: 162.02

MDL Number:: MFCD00125366

MOL File:: 70258-18-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:18:46

Product description	Number	Pack Size	Price
2-Chloro-5-(chloromethyl)pyridine 97%	516910	5g	$53.9
2-Chloro-5-(chloromethyl)pyridine 97%	516910	25g	$108
2-Chloro-5-(chloromethyl)pyridine >98.0%(GC)	C1628	5g	$379
2-Chloro-5-(chloromethyl)pyridine >98.0%(GC)	C1628	25g	$1120
2-Chloro-5-(chloromethyl)pyridine	C364715	25g	$110
More product size

Request For Quotation

2-Chloro-5-(chloromethyl)pyridine Properties

Melting point	37-42 °C(lit.)
Boiling point	267.08°C (rough estimate)
Density	1.4411 (rough estimate)
refractive index	1.6000 (estimate)
Flash point	>230 °F
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	-0.75±0.10(Predicted)
form	Moist Crystals
color	Beige
Water Solubility	Insoluble in water.
BRN	1635690
InChI	InChI=1S/C6H5Cl2N/c7-3-5-1-2-6(8)9-4-5/h1-2,4H,3H2
InChIKey	SKCNYHLTRZIINA-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(CCl)C=C1
CAS DataBase Reference	70258-18-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H314

Precautionary statements

P260-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

C,Xi,F

Risk Statements

22-34-36-10

Safety Statements

26-36/37/39-45-25-36-16

RIDADR

UN 3261 8/PG 2

WGK Germany

Hazard Note

Corrosive/Harmful

HazardClass

LACHRYMATOR, CORROSIVE

HazardClass

PackingGroup

HS Code

29333999

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Skin Corr. 1B

NFPA 704

	1
3		0

2-Chloro-5-(chloromethyl)pyridine price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	516910	2-Chloro-5-(chloromethyl)pyridine 97%	70258-18-3	5g	$53.9	2026-03-19	Buy
Sigma-Aldrich	516910	2-Chloro-5-(chloromethyl)pyridine 97%	70258-18-3	25g	$108	2026-03-19	Buy
TCI Chemical	C1628	2-Chloro-5-(chloromethyl)pyridine >98.0%(GC)	70258-18-3	5g	$379	2026-03-19	Buy
TCI Chemical	C1628	2-Chloro-5-(chloromethyl)pyridine >98.0%(GC)	70258-18-3	25g	$1120	2026-03-19	Buy
TRC	C364715	2-Chloro-5-(chloromethyl)pyridine	70258-18-3	25g	$110	2021-12-16	Buy

Product number	Packaging	Price	Buy
516910	5g	$53.9	Buy
516910	25g	$108	Buy
C1628	5g	$379	Buy
C1628	25g	$1120	Buy
C364715	25g	$110	Buy

2-Chloro-5-(chloromethyl)pyridine Chemical Properties,Uses,Production

Description

2-Chloro-5-chloromethylpyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds¹, having insecticidal activity. It is the raw material of pesticide products such as imidacloprid, acetamiprid as well as bactericide and herbicide^2,3.

Structure

2-Chloro-5-(chloromethyl)pyridine, C6H5Cl2N, is almost planar, with an r.m.s. deviation of 0.0146 Å for all atoms except for the 5-choloromethyl Cl atom. The offset Cl atom lies above this plane with a Cl—C—C angle of 111.11 (17)°. In the crystal, molecules are connected via intermolecular C—H⋯N hydrogen bonds, forming dimers. The crystals were obtained by dissolving 2-Chloro-5-(chloromethyl)pyridine (0.2 g, 1.2 mmol) in ethanol (25 ml) and evaporating the solvent slowly at room temperature for about 5 d[1].

Sources

https://www.alfa.com/en/catalog/L19284/
https://www.trc-canada.com/product-detail/?C364715
www.szqhbio.com/wap_news_detailen/id/1.htm

Chemical Properties

beige moist crystals

Uses

2-Chloro-5-(chloromethyl)pyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds.

Synthesis

Pentanenitrile, 4-chloro-4-(chloromethyl)-5-oxo-

150807-86-6

70258-18-3

General procedure for the synthesis of 2-chloro-5-chloromethylpyridine from the compound (CAS:150807-86-6): 18 g (0.1 mol) of 2-chloro-2-chloromethyl-4-cyano-butanal was dissolved in 50 ml of toluene, and 33 g (1.1 eq.) of solid phosgene was added to the toluene solution. The reaction mixture was stirred at 50°C for 5 hours. Upon completion of the reaction, the mixture was cooled to facilitate crystallization to afford the acetamiprid intermediate 2-chloro-5-chloromethylpyridine in 97% yield. Subsequently, the acetamiprid prodrug was further synthesized in 95% yield through methylation and esterification reaction steps.

References

[1] Zhi-Qiang Feng. “2-Chloro-5-(chloro-meth-yl)pyridine.” Acta crystallographica. Section E, Structure reports online 67 Pt 2 (2011): o366.

2-Chloro-5-(chloromethyl)pyridine synthesis

Synthesis of 2-Chloro-5-(chloromethyl)pyridine from Pentanenitrile, 4-chloro-4-(chloromethyl)-5-oxo-

2-Chloro-5-(chloromethyl)pyridine Preparation Products And Raw materials

Raw materials

Nicotinic acid 3-(Chloromethyl)pyridine 2-Chloro-5-trichloromethylpyridine Phosphorus pentoxide 2-Chloro-5-methylpyridine

1,3-Cyclopentadiene Pentanenitrile, 4-chloro-4-(chloromethyl)-5-oxo- Pentanamide, 4-chloro-4-(chloromethyl)-5-oxo- 2-Chloro-5-hydroxymethylpyridine (6-methoxypyridin-3-yl)methanol

5-(hydroxymethyl) pyridin-2(1H)-one N,N-Dibutylformamide Methyl 6-chloronicotinate 6-Chloronicotinic acid Cyanuric chloride

1of3

Preparation Products

Acetamiprid 4-(6-Chloro-pyridin-3-ylMethyl)-piperazine-1-carboxylic acid tert-butyl ester, 98+% C15H22ClN3O2, MW: 311.81 2-chloro-5-(piperidin-1-ylmethyl)pyridine 2-chloro-5-[(methylthio)methyl]pyridine(SALTDATA: FREE)

2-Chloro-5-(chloromethyl)pyridine Suppliers

Global( 598)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39927	58
AS WATER CO., LTD.	+86-18994963526 +8618994963526	1346073549@qq.com	United Kingdom	176	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	615	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55

Supplier	Advantage
Chongqing Chemdad Co., Ltd	58
AS WATER CO., LTD.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Nantong Guangyuan Chemicl Co,Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55

2-Chloro-5-Chloromethylpyridine: Applications in Agricultural Chemistry and its Green Synthesis
2-chloro-5-chloromethylpyridine(CCMP) is the shared key intermediate of the nicotinoids agricultural chemicals such as Provado....
Oct 22，2024

View Lastest Price from 2-Chloro-5-(chloromethyl)pyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-23	2-Chloro-5-chloromethylpyridine 70258-18-3			0.99		RongNa Biotechnology Co.,Ltd
2026-04-23	2-Chloro-5-chloromethylpyridine 70258-18-3	US $2.00 / KG	1KG	99%	1000mt/year	Jinan Finer Chemical Co., Ltd
2026-03-20	2-Chloro-5-chloromethylpyridine 70258-18-3	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

2-Chloro-5-chloromethylpyridine
70258-18-3
0.99
RongNa Biotechnology Co.,Ltd

2-Chloro-5-chloromethylpyridine
70258-18-3
US $2.00 / KG
99%
Jinan Finer Chemical Co., Ltd

2-Chloro-5-chloromethylpyridine
70258-18-3
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Chloro-5-(chloromethyl)pyridine Spectrum

2-Chloro-5-(chloromethyl)pyridine(70258-18-3)¹HNMR 2-Chloro-5-(chloromethyl)pyridine(70258-18-3)IR

70258-18-3(2-Chloro-5-(chloromethyl)pyridine)Related Search:

2-Chloro-5-trichloromethylpyridine 2-(Chloromethyl)pyridine 2,6-Lutidine Chromium picolinate Pyridine

Clopidol Azamethiphos 2,4,6-Collidine 4-Methylpyridine 2-Chloro-5-methylpyridine

2,6-DICHLORO-5-FLUORONICOTINOYL CHLORIDE 2,6-DICHLORO-3-(CHLOROMETHYL)PYRIDINE 2,3-Dichloro-5-(trichloromethyl)pyridine Difluorochloromethane 6-CHLORONICOTINOYL CHLORIDE

2,6-dichloro-3-(trichloromethyl)pyridine 2-CHLORO-5-(CHLOROMETHYL)PYRIDINE HYDROCHLORIDE 2,4-DICHLORO-5-(CHLOROMETHYL)-PYRIDINE

1of4

2-CHLORO-5-CHLOROMETHYLPYRIDINE 90% 2-Chloro-5-ChloroMethylPyridine(Ccmp)98% 2-Chloro-5-Chloro Methyl Pyridine (Ccmp) 98% Pyridine, 2-chloro-5-(chloromethyl)- (9CI) 2-Chloro-5-chloromethylpyridine, tech., 90% imidacloprid impurity 2-CHLORO-5-(CHLOROMETHYL)PYRIDINE[FOR IMIDACLOPRID] 2-CHLORO-5-CHLOROMETHYLPYRIDINE 2-CHLORO-5-CHLOROMETHYLPYRIDINE 2-CHLORO-5-CHLOROMETHYLPYRIDINE, 90%, TECH. 2-Chlor-5-Chlormethylpyridine 2-Chloro-5-Chloro-Me (6-Chloropyridin-3-yl)Methyl chloride 2-Chloro-5-pyridylMethyl chloride 2-Chloropyridin-5-ylMethyl chloride 3-(ChloroMethyl)-6-chloropyridine 5-(ChloroMethyl)-2-chloropyridine 6-Chlo AURORA KA-6694 2,5-DICHLORO-4-METHYL-PYRIDINE AKOS MSC-0759 TIMTEC-BB SBB003948 Pyridine, 2-chloro-5-(chloromethyl)- alpha,6-Dichloro-3-picoline 2-Chloro-5-(ch 2-Chloro-5-(chloromethyl)pyridine,96% 2-CHLORO-5-CHLOROMETHYL PYRIDINE (CCMP), 60% DMF 2-chloro-chloromethylpyridine 2-Chloro-5-(chloromethyl)pyridine> 60% in DMF Fampridine Impurity 215 C11397000 2-Chloro-5-(chloromethyl)pyridine 1-(Chloromethyl)-2,5-dichloropyridine 2-Chloro-5-chloromethylpyridine - [C4617] 2-CHLORO-5-CHLOROMETHYLPYRIDINE 70258-18-3 0258-18-3 BENZYL HALIDE Heterocyclic Building Blocks Halogenated Heterocycles Pyridines Chloropyridines Halopyridines Building Blocks Pharmaceutical intermediates C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Chloropyridines Halopyridines Methyl Halides Heterocycle-Pyridine series API Intermediate Pyridine series Methyl Halides HALOMETYL Pyridine 70258-18-3