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3,4-Dimethoxyphenylacetone

3,4-Dimethoxyphenylacetone Structure
3,4-Dimethoxyphenylacetone structure
CAS No.
776-99-8
Chemical Name:
3,4-Dimethoxyphenylacetone
Synonyms
Veratone;Weratone;Cucurbitone;Veratrum ketone;VERATRYL ACETONE;Veratryl-2-propanone;METHYL VERATRYL KETONE;Veratryl methyl ketone;Ranitidine Impurity 32;4-DiMethoxyphenyl)acetone
CBNumber:
CB2779551
Molecular Formula:
C11H14O3
Molecular Weight:
194.23
MDL Number:
MFCD00008772
MOL File:
776-99-8.mol
Last updated:2025-07-24 18:13:51
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3,4-Dimethoxyphenylacetone Properties

Melting point 136-139 °C
Boiling point 154-158 °C (12 mmHg)
Density 1.115 g/mL at 25 °C(lit.)
refractive index n20/D 1.5358(lit.)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Sparingly), Methanol (Slightly)
form clear liquid
color Light yellow to Yellow to Orange
Water Solubility Insoluble in water.
BRN 1107410
InChI InChI=1S/C11H14O3/c1-8(12)6-9-4-5-10(13-2)11(7-9)14-3/h4-5,7H,6H2,1-3H3
InChIKey UMYZWICEDUEWIM-UHFFFAOYSA-N
SMILES C(C1=CC=C(OC)C(OC)=C1)C(=O)C
CAS DataBase Reference 776-99-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII DM28QN9QDY
NIST Chemistry Reference 3,4-Dimethoxyphenylacetone(776-99-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Risk Statements  36/37/38
Safety Statements  24/25
WGK Germany  3
RTECS  UC1795500
HS Code  29145090
NFPA 704
1
1 0

3,4-Dimethoxyphenylacetone price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical V0052 3,4-Dimethoxyphenylacetone >97.0%(GC) 776-99-8 25mL $53 2025-07-31 Buy
TCI Chemical V0052 3,4-Dimethoxyphenylacetone >97.0%(GC) 776-99-8 500mL $527 2025-07-31 Buy
Matrix Scientific 172592 3,4-Dimethoxyphenylacetone 776-99-8 100g $96 2021-12-16 Buy
Frontier Specialty Chemicals JK598394 (3,4-Dimethoxyphenyl)acetone 97% 776-99-8 50g $98 2021-12-16 Buy
Biosynth Carbosynth FD71198 (3,4-Dimethoxyphenyl)acetone 776-99-8 250g $112.5 2021-12-16 Buy
Product number Packaging Price Buy
V0052 25mL $53 Buy
V0052 500mL $527 Buy
172592 100g $96 Buy
JK598394 50g $98 Buy
FD71198 250g $112.5 Buy

3,4-Dimethoxyphenylacetone Chemical Properties,Uses,Production

Chemical Properties

CLEAR YELLOW TO BROWN LIQUID

Uses

3,4-Dimethoxyphenylacetone was used as starting material in the synthesis of α-methyl-dopa, an important nonproteogenic α-amino acid for pharmaceutical applications. 3,4-Dimethoxyphenylacetone undergoes asymmetric amination catalyzed by Brevibacterium linens IFO 12141 strain to yield corresponding optically active amine

Synthesis Reference(s)

Chemistry Letters, 5, p. 1239, 1976
The Journal of Organic Chemistry, 29, p. 1424, 1964 DOI: 10.1021/jo01029a039

Synthesis

Methyl eugenol

93-15-2

3,4-Dimethoxyphenylacetone

776-99-8

GENERAL METHOD: To a THF/water (4:1, 15 mL) solution of methyl eugenol (1 mmol) was added 10% Pd/C (0.05 mmol) and KBrO3 (3 mmol). The reaction mixture was heated to reflux temperature. The reaction progress was monitored by TLC. After completion of the reaction, the mixture was diluted with water and filtered through Whatman 40 filter paper. The filtrate was extracted with ethyl acetate and the organic layers were combined. The organic layers were washed sequentially with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography to give 3,4-dimethoxypropiophenone.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 19, p. 2293 - 2295
[2] Tetrahedron Letters, 2009, vol. 50, # 24, p. 2893 - 2894
[3] Synthesis, 1992, # 12, p. 1229 - 1231
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975, p. 1548 - 1551

3,4-Dimethoxyphenylacetone synthesis

93-15-2
776-99-8
Synthesis of 3,4-Dimethoxyphenylacetone from Methyl eugenol

3,4-Dimethoxyphenylacetone Preparation Products And Raw materials

Raw materials

Veratraldehyde (2E)-3-(3,4-dimethoxyphenyl)-2-methylprop-2-enoic acid 1-(3,4-Dimethoxyphenyl)-2-(2-methoxyphenoxy)ethanone Methyl ether 1-Propanone,1-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)- 2-(3,4-DIMETHOXY-PHENYL)-N-METHOXY-N-METHYL-ACETAMIDE
Tetrahydrofuran Methyl eugenol 3-(3,4-DIMETHOXYPHENYL)-2-METHYL-1-PROPENE veratrylglycerol-beta-guaiacyl ether 3,4-DIMETHOXY-BETA-METHYL-BETA-NITROSTYRENE

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Preparation Products

Methyldopa FW 358.2 3,4-dimethoxy-alpha-methylphenethylamine

3,4-Dimethoxyphenylacetone Suppliers

Global( 254)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mujin Biotechnology Co.,Ltd 		+8613288715578 sales@hbmojin.com China 12580 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
JINING XINHE CHEMICAL CO., LTD 		+8615318402391 sales@xinhepharma.com China 809 58
Hebei Junhua Import and Export Co., LTD 		+86-18503288844 junhua1@hb-junhua.com China 957 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29733 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21622 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2955 58
Henan Xiangtong Chemical Co., Ltd. 		86-371-61312303 info@hnxtchem.com CHINA 292 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
Hebei Mujin Biotechnology Co.,Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
JINING XINHE CHEMICAL CO., LTD 		58
Hebei Junhua Import and Export Co., LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Jinan Finer Chemical Co., Ltd 		58
Henan Xiangtong Chemical Co., Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from 3,4-Dimethoxyphenylacetone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,4-Dimethoxyphenylacetone pictures 2025-08-15 3,4-Dimethoxyphenylacetone
776-99-8
 US $0.00-0.00 / kg 1kg 99% 1000 Hebei Junhua Import and Export Co., LTD
3,4-Dimethoxyphenylacetone pictures 2025-08-08 3,4-Dimethoxyphenylacetone
776-99-8
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
3,4-Dimethoxyphenylacetone pictures 2025-06-20 3,4-Dimethoxyphenylacetone
776-99-8
 US $50.00 / kg 1kg 0.99 10000 Hebei Yanxi Chemical Co., Ltd.

3,4-Dimethoxyphenylacetone Spectrum

3,4-Dimethoxyphenylacetone(776-99-8)MS3,4-Dimethoxyphenylacetone(776-99-8)1HNMR3,4-Dimethoxyphenylacetone(776-99-8)13CNMR3,4-Dimethoxyphenylacetone(776-99-8)IR1

776-99-8(3,4-Dimethoxyphenylacetone)Related Search:

3,4-Dimethoxyphenol Diphenyldimethoxysilane 1,1-Dimethoxyethane (3,4-Dimethoxyphenyl)acetic acid 3'-methoxypropiophenone
2,6-Dimethoxybenzaldehyde Veratric Acid Dimethyldimethoxysilane 1,3-Dimethoxybenzene 2-(3,4-Dimethoxyphenyl)ethanol
(3,4-Dimethoxyphenyl)acetonitrile 3,4-Dimethoxyacetophenone Veratraldehyde Dimethoxymethane Propiophenone
1-Deuteriopropan-2-one 2,5-DIMETHOXYPROPIOPHENONE Rotenone

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Veratone Veratrum ketone 3,4-DIMETHOXYPHENYLACETONE / METHYL VERATRYL KETONE 3,4-DIMETHOXYPHENYLACETONE 97+% VERATRYL ACETONE 1-(3,4-dimethoxyphenyl)acetone 1-(3,4-DIMETHOXYPHENYL)-2-PROPANONE 1-ACETONYL-3,4-DIMETHOXYBENZENE 3,4-DIMETHOXYPHENYLACETONE METHYL VERATRYL KETONE 1-(3,4-dimethoxyphenyl)-2-propanon 2-Propanone, 1-(3,4-dimethoxyphenyl)- 3,4-Dimethoxybenzyl methyl ketone 3,4-dimethoxybenzylmethylketone Veratryl-2-propanone 1-(3,4-Dimethoxyphenyl)-Actone Veratryl methyl ketone 4-DiMethoxyphenyl)acetone Methoxamine Impurity 3 (3,4-Dimethoxyphenylacetone) Cucurbitone Weratone Ranitidine Impurity 32 776-99-8 CH3O2C6H3CH2COCH3 C11H14O3 C11 to C12 Ketones Organic Building Blocks Building Blocks Carbonyl Compounds Aromatic Ketones (substituted) C11 to C12 Carbonyl Compounds Ketones Building Blocks C11 to C12 Carbonyl Compounds Chemical Synthesis Organic Building Blocks 776-99-8