Tislelizumab
- CAS No.
- 1858168-59-8
- Chemical Name:
- Tislelizumab
- Synonyms
- Tislelizumab;Tislelizumab (anti-PDCD1);Research Grade Tislelizumab;Research Grade Tislelizumab(DHH02206);Immunoglobulin G4, anti-(human programmed cell death protein 1) synthetic clone 317-4B6 heavy chain VH fragment fusion protein with human γ4 chain clone mut10 effector/constant domain fragment, disulfide with anti-(human programmed cell death protein 1) synthetic clone 317-4B6 light chain VL fragment fusion protein with human κ chain constant region fragment, dimer (ACI)
- CBNumber:
- CB28081045
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| form | Liquid |
| color | Colorless to light yellow |
| FDA UNII | 0KVO411B3N |
| NCI Drug Dictionary | tislelizumab |
Tislelizumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0437718 | Tislelizumab 98.10% | 1858168-59-8 | 1mg | $130 | 2026-06-04 | Buy |
| ChemScene | CS-0437718 | Tislelizumab 98.10% | 1858168-59-8 | 5mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-0437718 | Tislelizumab 98.10% | 1858168-59-8 | 10mg | $596 | 2026-06-04 | Buy |
| aablocks | AA027JEX | Tislelizumab | 1858168-59-8 | 1mg | $99 | 2026-06-02 | Buy |
| aablocks | AA027JEX | Tislelizumab | 1858168-59-8 | 5mg | $252 | 2026-06-02 | Buy |
Tislelizumab Chemical Properties,Uses,Production
Uses
Tislelizumab is a monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1), blocking its interaction with programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2). Tislelizumab can reactivate immune cells such as T lymphocytes and enhance anti-tumor activity. Tislelizumab can be used for the research of a variety of tumors including typical Hodgkin's lymphoma, urothelial carcinoma, non-small cell lung cancer and hepatocellular carcinoma[1][2][3].
in vivo
Tislelizumab (10 mg/kg; Intraperitoneal injection; Once a week; 4 weeks) has significant antitumor effect in the B16F10 melanoma mouse model[2].
| Animal Model: | B16F10/GM-CSF tumor cells treated hPD-1 C57BL/6 transgenic mice[2] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); once a week for 4 weeks. |
| Result: | Exerted remarkable antitumor efficacy, resulting in approximate 86.7% tumor growth inhibition. |
References
[1] Jie Wang, et al. Tislelizumab Plus Chemotherapy vs Chemotherapy Alone as First-line Treatment for Advanced Squamous Non-Small-Cell Lung Cancer: A Phase 3 Randomized Clinical Trial. JAMA Oncol. 2021 May 1;7(5):709-717. DOI:10.1001/jamaoncol.2021.0366
[2] Hong Y, et al. Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. FEBS Open Bio. 2021 Mar;11(3):782-792. DOI:10.1002/2211-5463.13102
[3] Zhu K, et al. Expression of HER2 in high-grade urothelial carcinoma based on Chinese expert consensus and the clinical effects of disitamab vedotin-tislelizumab combination therapy in the treatment of advanced patients. Front Pharmacol. 2024 Feb 22;15:1355081. DOI:10.3389/fphar.2024.1355081
Tislelizumab Preparation Products And Raw materials
Raw materials
Preparation Products
Tislelizumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
View Lastest Price from Tislelizumab manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-21 | Tislelizumab
1858168-59-8
|
$98.00-455.00 | 95.07% | 10g | TargetMol Chemicals Inc. |
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- Tislelizumab
1858168-59-8
- $98.00-455.00
- 95.07%
- TargetMol Chemicals Inc.
