SH-5
- CAS No.
- 701976-54-7
- Chemical Name:
- SH-5
- Synonyms
- SH-5;PIA 5;AKT INHIBITOR II;SH-5, Akt inhibitor;D-3-DEOXY-2-O-METHYL-MYO-INOSITOL 1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE];1-Deoxy-6-O-methyl-L-chiro-inositol 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate];L-chiro-Inositol, 1-deoxy-6-O-methyl-, 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate];SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II
- CBNumber:
- CB2816485
- Molecular Formula:
- C29H59O10P
- Molecular Weight:
- 598.75
- MDL Number:
- MFCD08703608
- MOL File:
- 701976-54-7.mol
SH-5 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | MP59676 | Phosphatidyl 1-(3-deoxy-2-O-methyl-D-myo-inositol) | 701976-54-7 | 1mg | $300 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0002701 | D-3-DEOXY-2-O-METHYL-MYO-INOSITOL-1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE] 95.00% | 701976-54-7 | 5MG | $495.92 | 2021-12-16 | Buy |
| Biosynth Carbosynth | MP59676 | Phosphatidyl 1-(3-deoxy-2-O-methyl-D-myo-inositol) | 701976-54-7 | 2mg | $500 | 2021-12-16 | Buy |
| AK Scientific | 6704CR | (2-Methoxy-3-octadecoxypropyl)(2,3,4-trihydroxy-6-methoxycyclohexyl)hydrogenphosphate | 701976-54-7 | 2mg | $725 | 2021-12-16 | Buy |
| Biosynth Carbosynth | MP59676 | Phosphatidyl 1-(3-deoxy-2-O-methyl-D-myo-inositol) | 701976-54-7 | 5mg | $975 | 2021-12-16 | Buy |
SH-5 Chemical Properties,Uses,Production
Uses
SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1].
Biological Activity
Cell permeable: yes', 'Primary Target
Akt', 'Product does not compete with ATP.', 'Reversible: yes
Enzyme inhibitor
This phosphatidylinositol analogue (FWfree-acid = 598.76 g/mol), also known as SH-5, inhibits the proto-oncogenic serine/threonine kinase Akt (protein kinase B), inducing apoptosis. Specific inhibition of Akt by these compounds validates ligand design targeted to the PH domains of crucial signaling proteins, thus providing a unique class of possible cancer therapeutics.
References
[1] Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76(11):1404-16. DOI:10.1016/j.bcp.2008.05.023
SH-5 Preparation Products And Raw materials
Raw materials
Preparation Products
SH-5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Changzhou Hopschain Chemical Co.,Ltd. | 0519-85528066 13775048983 | sales@hopschem.com | China | 31553 | 55 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9463 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | sean.lv@synzest.com | China | 10784 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-021-61109150 | sales@tcisct.com | China | 31121 | 58 |
| Vicbio Biotechnology Co., Ltd. | 13691409741 | info@vicbio.com | China | 2068 | 58 |
| Kamiya Biomedical Company | 1-+1 206-575-8068 1206-575-8068 | ordering@k-assay.com | China | 904 | 58 |