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ChemicalBook >> CAS DataBase List >>(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate Structure
(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate structure
CAS No.
2189684-54-4
Chemical Name:
(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate
Synonyms
Lenacapavir Intermediate 2;tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate;intermediate of Lenacapavir;Lenacapavir (GS-6207) Intermediate 2;(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate;tert-Butyl [(1S)-1-[3-bromo-6-[3-(methanesulfonyl)-3-methylbut-1-yn-1-yl]pyridin-2-yl]-2-(3,5-difluorophenyl)ethyl]carbamate;Tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2- 260 yl)-2-(3,5-difluorophenyl)ethyl)carbamate;(S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate tert-butyl ester;tert-butyl(S)-(1-(3-bromine-6-(3-methyl-3-(Methylsulfonyl)- 1-Alkyne-1-base)Pyridine-2-base)-2-(3,5-Difluorophenyl)Ethyl)Carbamate;N-[(1S)-1-[3-bromo-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-, 1,1-dimethylethyl ester
CBNumber:
CB28189080
Molecular Formula:
C24H27BrF2N2O4S
Molecular Weight:
557.45
MDL Number:
MOL File:
2189684-54-4.mol
Last updated:2026-09-12 18:51:27
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(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate Properties

Boiling point 636.8±55.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
pka 10.37±0.46(Predicted)
InChIKey OBUPKGOLRNAZIS-FQEVSTJZSA-N
SMILES C(OC(C)(C)C)(=O)N[C@H](C1=NC(C#CC(C)(S(C)(=O)=O)C)=CC=C1Br)CC1=CC(F)=CC(F)=C1

(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA0294GK Tert-Butyl (S)-(1-(3-Bromo-6-(3-Methyl-3-(Methylsulfonyl)But-1-Yn-1-Yl)Pyridin-2-Yl)-2-(3,5-Difluorophenyl)Ethyl)Carbamate 97% 2189684-54-4 250mg $79 2026-06-02 Buy
aablocks AA0294GK Tert-Butyl (S)-(1-(3-Bromo-6-(3-Methyl-3-(Methylsulfonyl)But-1-Yn-1-Yl)Pyridin-2-Yl)-2-(3,5-Difluorophenyl)Ethyl)Carbamate 97% 2189684-54-4 1g $127 2026-06-02 Buy
aablocks AA0294GK Tert-Butyl (S)-(1-(3-Bromo-6-(3-Methyl-3-(Methylsulfonyl)But-1-Yn-1-Yl)Pyridin-2-Yl)-2-(3,5-Difluorophenyl)Ethyl)Carbamate 97% 2189684-54-4 5g $223 2026-06-02 Buy
aablocks AA0294GK Tert-Butyl (S)-(1-(3-Bromo-6-(3-Methyl-3-(Methylsulfonyl)But-1-Yn-1-Yl)Pyridin-2-Yl)-2-(3,5-Difluorophenyl)Ethyl)Carbamate 97% 2189684-54-4 10g $377 2026-06-02 Buy
Arctom CS-0865063 (S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate >=98% 2189684-54-4 100mg $165 2026-05-26 Buy
Product number Packaging Price Buy
AA0294GK 250mg $79 Buy
AA0294GK 1g $127 Buy
AA0294GK 5g $223 Buy
AA0294GK 10g $377 Buy
CS-0865063 100mg $165 Buy

(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate Chemical Properties, Uses, Production

Uses

(S)-Tert-butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-YN-1-YL)pyridin-2-YL)-2-(3,5-difluorophenyl)ethyl)carbamate is a pharmaceutical intermediate compound that can be used in the preparation of HIV inhibitors.

Description

(S)-tert-butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate is a key pharmaceutical intermediate for lenapavir (trade name Sunlenca), used in the synthesis of anti-HIV-1 drugs. Lenapavir is a first-in-class long-acting HIV-1 capsid inhibitor administered subcutaneously, providing a prolonged treatment period, significantly reducing the treatment burden on patients, and exhibiting potent antiviral activity against drug-resistant HIV strains.

References

[1] Rajan, Srinivasan Thirumalai, et al. "Process for the preparation of tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl) but-1-yn-1-yl) pyridin-2-yl)-2-(3, 5-difluorophenyl) ethyl) carbamate." (2026).

(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate Suppliers

Global Suppliers ( 56)
Supplier Tel Email Country ProdList Advantage
Nantong Nuotai Biomedical Technology Co., Ltd. 0513-82206272 17706270880 2057095228@qq.com China 209 58
Shanghai Boc Chemical Co.,Ltd 021-34975603-808 18721111801 sales@bocpharma.com China 990 64
Shanghai Hope Chem Co., Ltd.， +21-18501659228 18501659228 info@hope-chem.com China 539 55
BOYAN PHARMA 18566078841 18566078841 tanyan@boyanpharma.com China 109 58
Gansu Haotian PharmaTech Co.,Ltd. 17789447501 zhuanxiajiang@haotianpharm.com China 211 58
Shanghai Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 811 58
WuYan Pharmaceutical Technology (Shanghai) Co., Ltd. 18621565901 sales@wuyanpharm.com China 139 55
Nanjing Tianyuexing Bio-tech Co.,Ltd. 吴经理15305186370 15305186370 david@chicopharm.com China 727 58
Porse Fine Chemical Co.,LTD 20-66003216 18666003216 info@porsefinechemical.com China 1963 62
INTERCHEMIE NANJING PHARMATECH CO., LTD 13656237714 13656237714; xiaokunfu@kyyykj.com China 297 55
Supplier Advantage
Nantong Nuotai Biomedical Technology Co., Ltd. 58
Shanghai Boc Chemical Co.,Ltd 64
Shanghai Hope Chem Co., Ltd.， 55
BOYAN PHARMA 58
Gansu Haotian PharmaTech Co.,Ltd. 58
Shanghai Haoyuan Chemexpress Co., Ltd. 58
WuYan Pharmaceutical Technology (Shanghai) Co., Ltd. 55
Nanjing Tianyuexing Bio-tech Co.,Ltd. 58
Porse Fine Chemical Co.,LTD 62
INTERCHEMIE NANJING PHARMATECH CO., LTD 55

View Latest Price from (S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lenacapavir (GS-6207) Intermediate 2 pictures 2026-08-08 Lenacapavir (GS-6207) Intermediate 2
2189684-54-4
 99.0%min 200kg Hangzhou ICH Biofarm Co., Ltd
Lenacapavir (GS-6207) Intermediate 2 pictures 2026-08-08 Lenacapavir (GS-6207) Intermediate 2
2189684-54-4
 99.0%min 200kg Hangzhou ICH Biofarm Co., Ltd
Lenacapavir (GS-6207) Intermediate 2 pictures 2026-08-08 Lenacapavir (GS-6207) Intermediate 2
2189684-54-4
 99.0%min 200kg Hangzhou ICH Biofarm Co., Ltd
Carbamic acid, N-[(1S)-1-[3-bromo-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-, 1,1-dimethylethyl ester Carbanic acid,N-[CIS)-1-[3-bromo-6-[3-methyl-3(methyl)sulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-,1,1-dimethylethylester intermediate of Lenacapavir (S)-tert-Butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate Tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2- 260 yl)-2-(3,5-difluorophenyl)ethyl)carbamate 1,1-Dimethylethyl N-[(1S)-1-[3-bromo-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]carbamate Lenacapavir (GS-6207) Intermediate 2 tert-butyl(S)-(1-(3-bromine-6-(3-methyl-3-(Methylsulfonyl)- 1-Alkyne-1-base)Pyridine-2-base)-2-(3,5-Difluorophenyl)Ethyl)Carbamate N-[(1S)-1-[3-bromo-6-[3-methyl-3-(methylsulfonyl)-1-butyn-1-yl]-2-pyridinyl]-2-(3,5-difluorophenyl)ethyl]-, 1,1-dimethylethyl ester (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate tert-butyl ester Lenacapavir Intermediate 2 tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate tert-Butyl [(1S)-1-[3-bromo-6-[3-(methanesulfonyl)-3-methylbut-1-yn-1-yl]pyridin-2-yl]-2-(3,5-difluorophenyl)ethyl]carbamate 2189684-54-4 C24H27BrF2N2O4S