EST64454
- CAS No.
- 1950569-11-5
- Chemical Name:
- EST64454
- Synonyms
- EST64454;EST64454 HCl;EST64454 hydrochloride;EST64454 hydrochloride, 10 mM in DMSO;pain,Inhibitor,EST 64454,EST64454 hydrochloride,nerve,selective,EST-64454 hydrochloride,Sigma Receptor,EST-64454,oral,inhibit
- CBNumber:
- CB28210252
- Molecular Formula:
- C18H23ClF2N4O2
- Molecular Weight:
- 400.85
- MDL Number:
- MFCD33023223
- MOL File:
- 1950569-11-5.mol
EST64454 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 25mg | $950 | 2021-12-16 | Buy |
| ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 50mg | $1450 | 2021-12-16 | Buy |
| ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 100mg | $2250 | 2021-12-16 | Buy |
EST64454 Chemical Properties,Uses,Production
Uses
EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain[1].
Biological Activity
EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain[1]. EST64454 (10 mg/kg; p.o.; male Wistar rats) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% are 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively[1].EST64454 (10 mg/kg; p.o.; male CD1 mice) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% were 1178 ng/mL, <1 hours, 2645 ng h/mL, 1.2 l/kg and 60%, respectively[1].
in vivo
EST64454 (10 mg/kg; p.o.; male Wistar rats) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% are 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively[1].
EST64454 (10 mg/kg; p.o.; male CD1 mice) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% were 1178 ng/mL, <1 hours, 2645 ng h/mL, 1.2 l/kg and 60%, respectively[1].
| Animal Model: | Male Wistar rats (250-300 g)[1] |
| Dosage: | 10 mg/kg |
| Administration: | P.o. (Pharmacokinetic Analysis) |
| Result: | The Cmax, t1/2, AUC0-∞, Vss and F% were 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively. |
References
[1]. Díaz JL, et al. EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. J Med Chem. 2020;63(23):14979-14988.
EST64454 Preparation Products And Raw materials
Raw materials
Preparation Products
EST64454 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9342 | 58 |
| Wuhan Augda Biotechnology Co., Ltd | 15071299552 | 262933239@qq.com | China | 6952 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24863 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |