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ChemicalBook >> CAS DataBase List >>Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester Structure
Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester structure
CAS No.
2244161-73-5
Chemical Name:
Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester
Synonyms
DOLUTEGRAVIR IMPURITY;Dolutegravir Impurity 60;Doultegravir carbamate impurity;Des-butanoyl 3,4-Didehydro-N-butyl(2,4-difluorobenzyl)carbamate Dolutegravir;sodium (R)-7-((2,4-difluorobenzyl)carbamoyl)-2-(4-(((2,4-difluorobenzyl)carbamoyl)oxy)butan-2-yl)-1,
CBNumber:
CB28214977
Molecular Formula:
C28H24F4N4O6
Molecular Weight:
588.51
MDL Number:
MOL File:
2244161-73-5.mol
Last updated:2022-12-21 16:56:50
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Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester Properties

Boiling point 778.0±60.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
pka 4.50±1.00(Predicted)
FDA UNII YMS8WH5LQD

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester Chemical Properties, Uses, Production

Uses

Des-butanoyl 3,4-Didehydro-N-butyl(2,4-difluorobenzyl)carbamate Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester Suppliers

Global Suppliers ( 13)
Supplier Tel Email Country ProdList Advantage
CR Corporation Limited fred.wen@crcorporation.cn China 8642 58
AFINE CHEMICALS LIMITED +86-571-85134551 +86-18958018566 info@afinechem.com China 15030 58
Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd. 020-89854820 sales@jzpharma.cn China 1550 58
QUALITY CONTROL SOLUTIONS LTD. +86-0755-66853366 +86-13670046396 export03@qcsrm.com China 24318 58
Shenzhen Roark Pharma-Tec Co., Ltd. 13128912434 2880126944@qq.com China 3159 58
Aurisco Pharmaceutical (Tianjin) Inc. 022-59885855 China 96 58
Cato Research Chemicals Inc. 81960175 18933936954 2853283383@qq.com China 11418 58
Changzhou Xianglong Pharmaceutical Technology Co., Ltd., 18915873328 18915873328 sales@xianglongpharm.com China 11049 58
Changzhou Extraordinary Pharmatech co., LTD. 0519-82111935 15195055733 info@feifanchem.com China 737 58
Hangzhou Yiyun Guoke Biotechnology Co., Ltd. 18457506494 3779628498@qq.com China 8573 58
Supplier Advantage
CR Corporation Limited 58
AFINE CHEMICALS LIMITED 58
Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd. 58
QUALITY CONTROL SOLUTIONS LTD. 58
Shenzhen Roark Pharma-Tec Co., Ltd. 58
Aurisco Pharmaceutical (Tianjin) Inc. 58
Cato Research Chemicals Inc. 58
Changzhou Xianglong Pharmaceutical Technology Co., Ltd., 58
Changzhou Extraordinary Pharmatech co., LTD. 58
Hangzhou Yiyun Guoke Biotechnology Co., Ltd. 58
DOLUTEGRAVIR IMPURITY sodium (R)-7-((2,4-difluorobenzyl)carbamoyl)-2-(4-(((2,4-difluorobenzyl)carbamoyl)oxy)butan-2-yl)-1, Dolutegravir Impurity 60 Des-butanoyl 3,4-Didehydro-N-butyl(2,4-difluorobenzyl)carbamate Dolutegravir Doultegravir carbamate impurity 2244161-73-5 C28H24F4N4O6