Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>R-Methyl 1-Boc-piperidine-2-carboxylate

R-Methyl 1-Boc-piperidine-2-carboxylate

R-Methyl 1-Boc-piperidine-2-carboxylate Structure
R-Methyl 1-Boc-piperidine-2-carboxylate structure
CAS No.
164456-75-1
Chemical Name:
R-Methyl 1-Boc-piperidine-2-carboxylate
Synonyms
R-Methyl 1-Boc-piperidine-2-carboxylate;Methyl (R)-1-Boc-2-piperidinecarboxylate;Methyl (R)-1-Boc-piperidine-2-carboxylate;Boc-R-piperidine-2-carboxylic acid Methyl ester;Boc-D-piperidine-2-carboxylic acid Methyl ester;1-(R)-tert-butyl 2-methyl piperidine-1,2-dicarboxylate;(R)-1-tert-Butyl 2-Methyl piperidine-1,2-dicarboxylate;1-tert-butyl 2-Methyl (2R)-piperidine-1,2-dicarboxylate;1-(tert-butyl) 2-methyl (R)-piperidine-1,2-dicarboxylate;1-O-tert-butyl 2-O-methyl (2R)-piperidine-1,2-dicarboxylate
CBNumber:
CB2841782
Molecular Formula:
C12H21NO4
Molecular Weight:
243.3
MDL Number:
MFCD09038772
MOL File:
Mol file
MSDS File:
SDS
Last updated:2026-09-12 18:51:27
Request For Quotation

R-Methyl 1-Boc-piperidine-2-carboxylate Properties

Boiling point 307.4±35.0 °C(Predicted)
Density 1.094±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka -3.28±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

R-Methyl 1-Boc-piperidine-2-carboxylate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 304765 (R)-1-tert-Butyl 2-methyl piperidine-1,2-dicarboxylate 164456-75-1 1.00g $67 2026-05-19 Buy
Matrix Scientific 304765 (R)-1-tert-Butyl 2-methyl piperidine-1,2-dicarboxylate 164456-75-1 5.00g $215 2026-05-19 Buy
Matrix Scientific 304765 (R)-1-tert-Butyl 2-methyl piperidine-1,2-dicarboxylate 164456-75-1 10.00g $365 2026-05-19 Buy
Synthonix B56279 (R)-1-tert-Butyl 2-methyl piperidine-1,2-dicarboxylate 95+% 164456-75-1 250mg $90 2026-05-06 Buy
Synthonix B56279 (R)-1-tert-Butyl 2-methyl piperidine-1,2-dicarboxylate 95+% 164456-75-1 1g $160 2026-05-06 Buy
Product number Packaging Price Buy
304765 1.00g $67 Buy
304765 5.00g $215 Buy
304765 10.00g $365 Buy
B56279 250mg $90 Buy
B56279 1g $160 Buy

R-Methyl 1-Boc-piperidine-2-carboxylate Chemical Properties, Uses, Production

Synthesis

(R)-(+)-N-Boc-2-piperidinecarboxylic acid

28697-17-8

Iodomethane

74-88-4

R-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE

164456-75-1

General steps: 1. In a dry reaction flask, (R)-1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (5.1 g, 22.2 mmol) was dissolved in DMF (60 mL). 2. K2CO3 (12.3 g, 88.8 mmol) and iodomethane (1.7 mL, 26.6 mmol) were added sequentially to the above solution. 3. The reaction mixture was stirred at room temperature overnight. 4. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate. 5. The organic layer was separated and washed 6 times with distilled water and once with saturated saline. 6. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated to give methyl (R)-N-Boc-piperidine-2-carboxylate (5.4 g, 99% yield). 7. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.82 (m, 1H), 3.99 (m, 1H), 3.75 (s, 3H), 2.95 (m, 1H), 2.21 (m, 1H), 2.45 (m, 14H).

References

[1] Patent: US2007/259916, 2007, A1. Location in patent: Page/Page column 9
[2] Patent: US2007/259862, 2007, A1. Location in patent: Page/Page column 10
[3] Patent: US2004/198701, 2004, A1. Location in patent: Page/Page column 10
[4] Patent: US2005/227969, 2005, A1. Location in patent: Page/Page column 10

R-Methyl 1-Boc-piperidine-2-carboxylate Preparation Products And Raw materials

Raw materials

(R)-(+)-N-Boc-2-piperidinecarboxylic acid Iodomethane N,N-Dimethylformamide Potassium carbonate

Preparation Products

R-Methyl 1-Boc-piperidine-2-carboxylate Suppliers

Global Suppliers ( 25)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9848 55
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2580 60
NINGBO INNO PHARMCHEM CO.,LTD. 86-574-27787657 info@dearchem.com China 4607 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Shanghai Medicil Biomedical Co., Ltd. 021-50822001 marketing@medicilon.com.cn China 1151 58
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 17705817739 info@dycnchem.com China 52451 58
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
Shanghai Longsheng chemical Co.,Ltd. 59
Amatek Scientific Co. Ltd. 55
Chengdu Firster Pharmaceutical Co., Ltd. 60
NINGBO INNO PHARMCHEM CO.,LTD. 58
Amadis Chemical Company Limited 58
Aikon International Limited 58
Shanghai Medicil Biomedical Co., Ltd. 58
Dayang Chem (Hangzhou) Co.,Ltd. 58

164456-75-1 (R-Methyl 1-Boc-piperidine-2-carboxylate) Related Search:

S-Methyl 1-Boc-piperidine-2-carboxylate (R)-Piperidine-2-carboxylic acid methyl ester hydrochloride H-HomoPro-OMe HCl Methyl 2-piperidinecarboxylate Ethyl N-Boc-piperidine-2-carboxylate
Benzyl 2-methylpiperidine-1,2-dicarboxylate

1of2

1-tert-butyl 2-Methyl (2R)-piperidine-1,2-dicarboxylate Boc-D-piperidine-2-carboxylic acid Methyl ester Boc-R-piperidine-2-carboxylic acid Methyl ester (R)-1-tert-Butyl 2-Methyl piperidine-1,2-dicarboxylate Methyl (R)-1-Boc-2-piperidinecarboxylate 1-(R)-tert-butyl 2-methyl piperidine-1,2-dicarboxylate 1,2-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-methyl ester, (2R)- Methyl (R)-1-Boc-piperidine-2-carboxylate 1-O-tert-butyl 2-O-methyl (2R)-piperidine-1,2-dicarboxylate 1-(tert-butyl) 2-methyl (R)-piperidine-1,2-dicarboxylate R-Methyl 1-Boc-piperidine-2-carboxylate 164456-75-1