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2-Chloroisonicotinaldehyde

2-Chloroisonicotinaldehyde Structure
2-Chloroisonicotinaldehyde structure
CAS No.
101066-61-9
Chemical Name:
2-Chloroisonicotinaldehyde
Synonyms
2-chloro-3-forMylpyridine-4-carboxylic acid;oroisonicotinaL;BUTTPARK 154\50-03;TIMTEC-BB SBB004156;2-Chloroisonicotinal;2-Chloronicotinealdehyde;2-CHLORO-4-FORMYLPYRIDINE;2-CHLOROISONICOTINALDEHYDE;CHLORO-2-FORMYL-3-PYRIDINE;2-Chloroisonicotinaldehyde 97%
CBNumber:
CB2852601
Molecular Formula:
C6H4ClNO
Molecular Weight:
141.56
MDL Number:
MFCD06651557
MOL File:
101066-61-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:51:02
Product description Number Pack Size Price
2-Chloro-4-pyridinecarboxaldehyde 97% 707333 250mg $47.4
2-Chloro-4-pyridinecarboxaldehyde technical, ≥90% 689734 500mg $107
2-Chloro-4-pyridinecarboxaldehyde >98.0%(GC) C2723 1g $84
2-Chloro-4-pyridinecarboxaldehyde >98.0%(GC) C2723 5g $333
2-Chloroisonicotinaldehyde ≥96% CS-W011025 5g $24
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2-Chloroisonicotinaldehyde Properties

Melting point 46-50 °C
Boiling point 243.4±20.0 °C(Predicted)
Density 1.332±0.06 g/cm3(Predicted)
Flash point >230 °C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -1.23±0.10(Predicted)
form powder to crystal
color White to Almost white
Sensitive Air Sensitive
BRN 7986625
InChI InChI=1S/C6H4ClNO/c7-6-3-5(4-9)1-2-8-6/h1-4H
InChIKey UFPOSTQMFOYHJI-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC(C=O)=C1
CAS DataBase Reference 101066-61-9(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H317-H319-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,Xi
Risk Statements  22-36-43-36/37/38-20/21/22-42/43
Safety Statements  26-36/37-36/37/39-22-45-23
WGK Germany  3
Hazard Note  Harmful
HazardClass  IRRITANT
HS Code  2933399990
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3
NFPA 704
1
2 0

2-Chloroisonicotinaldehyde price More Price(87)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 707333 2-Chloro-4-pyridinecarboxaldehyde 97% 101066-61-9 250mg $47.4 2026-04-30 Buy
Sigma-Aldrich 689734 2-Chloro-4-pyridinecarboxaldehyde technical, ≥90% 101066-61-9 500mg $107 2026-04-30 Buy
TCI Chemical C2723 2-Chloro-4-pyridinecarboxaldehyde >98.0%(GC) 101066-61-9 1g $84 2026-04-30 Buy
TCI Chemical C2723 2-Chloro-4-pyridinecarboxaldehyde >98.0%(GC) 101066-61-9 5g $333 2026-04-30 Buy
ChemScene CS-W011025 2-Chloroisonicotinaldehyde ≥96% 101066-61-9 5g $24 2026-06-04 Buy
Product number Packaging Price Buy
707333 250mg $47.4 Buy
689734 500mg $107 Buy
C2723 1g $84 Buy
C2723 5g $333 Buy
CS-W011025 5g $24 Buy

2-Chloroisonicotinaldehyde Chemical Properties,Uses,Production

Chemical Properties

white to yellow solid

Uses

2-Chloropyridine-4-carboxaldehyde is a reagent used in the chemoenzymic synthesis of α-fluoro β-hydroxy carboxylic esters. It is also a reagent in the combinatorial synthesis of methylene sulfonamides and related compounds as potential kinase inhibitors.

Synthesis

(2-CHLORO-PYRIDIN-4-YL)-METHANOL

100704-10-7

2-Chloroisonicotinaldehyde

101066-61-9

The general procedure for the synthesis of 2-chloropyridine-4-carboxaldehyde from 2-chloro-4-hydroxymethylpyridine was as follows: in a 250 mL three-necked flask equipped with a cryogenic thermometer and two constant-pressure dropping funnels, a dichloromethane (15 mL) solution of oxalyl dichloride (1.24 g, 9.81 mmol) was added. The reaction system was cooled to -78 °C under nitrogen protection and stirred. The first constant pressure dropping funnel was connected to the nitrogen line and a dichloromethane (15 mL) solution of 2-chloro-4-hydroxymethylpyridine (0.94 g, 6.54 mmol) was added. A solution of anhydrous dimethyl sulfoxide (1.7 mL, 19.63 mmol) in dichloromethane (2 mL) was added to the other dropping funnel, and the solution was slowly added dropwise (25 min), keeping the reaction temperature between -60°C and -70°C. After the dropwise addition, the reaction system was slowly warmed up to -60 °C over 20 min, and then a dichloromethane solution of 2-chloro-4-hydroxymethylpyridine was added dropwise (50 min), maintaining the temperature between -50 °C and -60 °C. Subsequently, the reaction mixture was warmed to -45 °C over 30 min. The dropping funnel was washed with dichloromethane (2 x 5 mL) and a solution of triethylamine (480 μL, 6.51 mmol) in dichloromethane (4 mL) was added to the reaction mixture (10 min), and finally the mixture in the reaction flask was warmed up to 0 °C within 10 min. The reaction solution was transferred to a 500 mL dispensing funnel and 130 mL of 5% NH4Cl aqueous solution was added. The two phases were separated and the aqueous phase was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, washed with 1 M phosphate buffer (pH=7; 4×100 mL), dried over MgSO4, filtered and concentrated. 2-Chloropyridine-4-carbaldehyde was obtained as an orange solid (0.740 g, 76% yield). Product characterization: mw: 141.57; yield: 76%; orange solid. rf: 0.35 (EtOAc:cyclohexane=30:70). 1H-NMR (CDCl3, δ): 7.65 (dd, 1H, J=5.0 Hz, J=1.3 Hz, ArH), 7.75 (d, 1H, J=1.3 Hz, ArH), 8.66 (d. 1H, J=5.0 Hz, ArH), 10.05 (s, 1H, CHO).

References

[1] Patent: WO2008/11478, 2008, A2. Location in patent: Page/Page column 77-78
[2] Patent: US6218537, 2001, B1

2-Chloroisonicotinaldehyde Preparation Products And Raw materials

Raw materials

Tetrahydrofuran Lithium Aluminum Hydride METHYL 2-CHLOROISONICOTINATE (2-CHLORO-PYRIDIN-4-YL)-METHANOL Sodium carbonate
Potassium carbonate Dichloromethane Dimethyl sulfoxide Oxalyl chloride Triethylamine

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Preparation Products

2-Chloroisonicotinaldehyde Suppliers

Global( 281)Suppliers
Supplier Tel Email Country ProdList Advantage
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Richest Group Ltd 		18017061086 oled@richest-group.com CHINA 5600 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
Frapp's ChemicalNFTZ Co., Ltd. 		50
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Richest Group Ltd 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 2-Chloroisonicotinaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloroisonicotinaldehyde pictures 2025-11-18 2-Chloroisonicotinaldehyde
101066-61-9
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Chloroisonicotinaldehyde pictures 2025-04-04 2-Chloroisonicotinaldehyde
101066-61-9
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-Chloroisonicotinaldehyde pictures 2021-07-02 2-Chloroisonicotinaldehyde
101066-61-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Chloroisonicotinaldehyde Spectrum

2-Chloroisonicotinaldehyde(101066-61-9)1HNMR

101066-61-9(2-Chloroisonicotinaldehyde)Related Search:

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2-CHLOROISONICOTINALDEHYDE 2-CHLOROPYRIDINE-4-CARBOXALDEHYDE 2-CHLOROPYRIDINE-3-CARBOXALDEHYDE 2-CHLOROPYRIDINE-4-CARBALDEHYDE 2-CHLORO-PYRIDIN-3-CARBALDEHYDE 2-CHLORO-4-FORMYLPYRIDINE CHLORO-2-FORMYL-3-PYRIDINE BUTTPARK 154\50-03 2-CHLORO-4-PYRIDINECARBOXALDEHYDE 2-Chloronicotinealdehyde 4-Pyridinecarboxaldehyde, 2-chloro- (9CI) 2-Chloropyridine-4-carboxaldehyde 97% TIMTEC-BB SBB004156 2-Chloroisonicotinaldehyde 97% 2-Chloroisonicotinal 4-Pyridinecarboxaldehyde, 2-chloro- 2-chloro-3-forMylpyridine-4-carboxylic acid 2-chloropyridin-4-carbaldehyde 2-chloro-pyridin-4-ylcarbaldehyde 2-Chloropyridine-4-carboxaldehyde, 2-Chloro-4-formylpyridine 2-Chloro-4-pyridinecarboxaldehyde 2-Chloro-4-pyridinecarboxaldehyde > oroisonicotinaL 2-Chloroisonicotinaldehyde ISO 9001：2015 REACH 5-Bromo-263-fluorobenzylamine&hydrochloride 2-Chloro-4-pyridinecarbaldehyde 2-Chloropyridine-4-carboxaldehyde, CAS 101066-61-9 101066-61-9 1010166-61-9 C6H4NOCl Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines C1 to C6 C5 to C6 C6 to C7 Carbonyl Compounds Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Organic Building Blocks PYRIDINE ALDEHYDE pharmacetical Aldehydes Pyridines Building Blocks