(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- CAS No.
- 28416-82-2
- Chemical Name:
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- Synonyms
- FluMethasone acid;Flumetasone acid;Fluticasone Acid;(6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid;(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid;Axon 1170;impurity J;BNKY011-FP01;BNKY012-FF01;flumethason acid
- CBNumber:
- CB2854948
- Molecular Formula:
- C21H26F2O5
- Molecular Weight:
- 396.42
- MDL Number:
- MFCD09832931
- MOL File:
- 28416-82-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Properties
| Melting point | 303-305°C |
|---|---|
| Boiling point | 568.4±50.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.49±0.70(Predicted) |
| color | White to Off-White |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | QSVBUQTYFQFEHC-TXKOFOEMNA-N |
| SMILES | [C@]12(C)C=CC(=O)C=C1[C@@H](F)C[C@@]1([H])[C@]3([H])C[C@@H](C)[C@](O)(C(O)=O)[C@@]3(C)C[C@H](O)[C@]21F |&1:0,8,11,13,16,18,23,26,28,r| |
| FDA UNII | EUS9FD6209 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| WGK Germany | WGK 3 |
| HS Code | 2937220000 |
| Storage Class | 11 - Combustible Solids |
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27855 | Fluticasone 17β-Carboxylic Acid ≥98% | 28416-82-2 | 50mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 27855 | Fluticasone 17β-Carboxylic Acid ≥98% | 28416-82-2 | 100mg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 27855 | Fluticasone 17β-Carboxylic Acid ≥98% | 28416-82-2 | 250mg | $333 | 2026-04-30 | Buy |
| Cayman Chemical | 27855 | Fluticasone 17β-Carboxylic Acid ≥98% | 28416-82-2 | 500mg | $589 | 2026-04-30 | Buy |
| Biosynth | FF23512 | Fluticasone 17b-carboxylic acid | 28416-82-2 | 5g | $217.7 | 2026-06-04 | Buy |
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Chemical Properties, Uses, Production
Description
Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate .
Chemical Properties
White Solid
Uses
The major metabolite of Fluticasone. Anti-inflammatory agent.
Uses
Fluticasone intermediate. Anti-inflammatory agent
General Description
Fluticasone 17β-carboxylic acid ((6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid) is a compound of interest in studying structure-activity relationships within corticosteroid analogs. In research, this compound is examined for its potential interactions with glucocorticoid receptors, given its structural similarity to fluticasone, which is known for its affinity to these receptors. The 17β-carboxylic acid moiety may alter the compound's binding characteristics. In biochemistry, fluticasone 17β-carboxylic acid is used to probe the metabolic pathways of fluticasone, as it may be a metabolite or intermediate.
Synthesis
To a suspension of flumethasone (1.19 g, 2.9 mmol) in tetrahydrofuran (11 ml) was added a solution of periodic acid (2.25 g, 9.9 mmol) in water (5.3 ml). The resulting solution was stirred at RT for 1 h. The tetrahydrofuran was removed in vacuo to leave an aqueous suspension which was filtered, and the solid washed with water and dried to give 1.17 g (100%) of the (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (Fluticasone 17β-Carboxylic Acid) as a colorless solid.
References
[1] JIADI ZHOU Weike S Can Jin. Improved Synthesis of Fluticasone Propionate[J]. Organic Process Research & Development, 2014, 18 8: 928-933. DOI: 10.1021/op5001226
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suizhou Jiake Biological Engineering Co., Ltd. | 0722-3632789 18008664168 | 2549463910@qq.com | China | 121 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6740 | 52 |
| Wuhan Fortuna Chemical Co., Ltd | 027-59207852 13308628970 | buy@fortunachem.com | China | 2684 | 58 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-4000505016 13380397412 | 3001272453@qq.com | China | 5000 | 50 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
View Latest Price from (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
28416-82-2
|
$80.00-800.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2026-04-21 | Fluticasone 17β-Carboxylic Acid
28416-82-2
|
$246.00-1090.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-03-12 | Fluticasone Carboxylic Acid
28416-82-2
|
10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
28416-82-2
- $80.00-800.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Fluticasone 17β-Carboxylic Acid
28416-82-2
- $246.00-1090.00
- TargetMol Chemicals Inc.
-
- Fluticasone Carboxylic Acid
28416-82-2
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
