ChemicalBook >> CAS DataBase List >>[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester

[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester

CAS No.
147126-75-8
Chemical Name:
[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester
Synonyms
FCME;Emtricitabine Impurity 23;Emtricitabine Impurity 38;The intermediate of his bin;Emtricitabine Menthyl Ester;EMtricitabine InterMediate- FCME;(2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-;[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-AMino-5-fluoro-2-oxo-1(2H)-;(2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxyli...;(1R,2S,5R)-Methyl-5(S)-Flurorcytocine-1-Yl-[1,3]-Oxatholane-2Rcarboxylate
CBNumber:
CB2855107
Molecular Formula:
C18H26FN3O4S
Molecular Weight:
399.48
MDL Number:
MFCD22374171
MOL File:
147126-75-8.mol
MSDS File:
SDS
Last updated:2026-05-28 00:50:26
Product description Number Pack Size Price
Emtricitabine Menthyl Ester TRC-E525310-2.5G 2.5g $90
Emtricitabine Menthyl Ester TRC-E525310-1G 1g $70
5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester NA32529 0.5g $250
5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester NA32529 1g $350.99
5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester NA32529 5g $1403.9
More product size

[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester Properties

Melting point 180 - 183°C (dec.)
Boiling point 508.5±60.0 °C(Predicted)
Density 1.47
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility Chloroform (Slightly), Methanol (Slightly)
pka 2.40±0.10(Predicted)
form Solid
color White to Off-White
Stability Hygroscopic

SAFETY

Risk and Safety Statements

[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-E525310-2.5G Emtricitabine Menthyl Ester 147126-75-8 2.5g $90 2026-06-03 Buy
TRC TRC-E525310-1G Emtricitabine Menthyl Ester 147126-75-8 1g $70 2026-06-03 Buy
Biosynth NA32529 5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester 147126-75-8 0.5g $250 2026-06-04 Buy
Biosynth NA32529 5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester 147126-75-8 1g $350.99 2026-06-04 Buy
Biosynth NA32529 5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester 147126-75-8 5g $1403.9 2026-06-04 Buy
Product number Packaging Price Buy
TRC-E525310-2.5G 2.5g $90 Buy
TRC-E525310-1G 1g $70 Buy
NA32529 0.5g $250 Buy
NA32529 1g $350.99 Buy
NA32529 5g $1403.9 Buy

[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester Chemical Properties,Uses,Production

Uses

Emtricitabine Menthyl Ester is an impurity of Emtricitabine (E525000). Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).

[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester 5-(4-amino-5-fluoro-2-oxo-1(2h)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxylic acid menthyl ester (FCME) (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxylic acid menthyl ester (1''R,2''S,5''R)-MENTHYL-(2R-5R)-(4-AMINO-2-OXO-2H-5-FLUORO-PYRIMIDIN-1-YL)-[1,3]OXATHIOLANE (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2- (5-methyl-2-propan-2-ylcyclohexyl) 5-(4-amino-5-fluoro-2-oxopyrimidin-1-yl)-1,3-oxathiolane-2-carboxylate (1R,2S,5R)-MENTHYL-5(S)-FLUOROCYTOSINE-1-YL-[1,3]-OXATHIOLANE-2R-CARBOXYLATE EMtricitabine InterMediate- FCME [1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-AMino-5-fluoro-2-oxo-1(2H)- (2S,5R)-(1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl 5-(4-aMino-5-fluoro-2-oxopyriMidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate (2S,5R)5(4AMINO-5-FLUORO2-OXO2H-PYRIMIDIN1YL)(1,3)OXATHIOLANE2CARBOXYLIC ACID2S-ISOPROPYL-5R-METHYL-1R-CYCLOHEYL ESTER (2R,5S)-5-(4-AMino-5-fluoro-2-oxo-2H-pyriMidin-1-yl)-[1,3]oxathiolane-2-carboxylic Acid,(2S)-Isopropyl-(5R)-Methyl-(1R)-cyclohexyl Ester (2S,5R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1, The intermediate of his bin 2R,5S-5-(4-AMINO-5-FLUORO-2-OXO-2H-PYRIMIDIN-1YL)-[1,3]-OXATHIOLANE-2-CARBOXYLIC ACID, 2S-ISOPROPYL-5R-METHYL-1R-CYCLOHXYL ESTER (1R, 2S, 5R)-MENTHYL-(2R, 5S)-5-(4-AMINO-5-FLUORO-2-OXO-2H-PYRIMIDIN-1-YL)-[1, 3]-OXATHIOLANE-2-CARBOXYLATE (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxylic acid methyl ester (2S,5R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl) Emtricitabine Impurity 23 Emtricitabine Menthyl Ester Emtricitabine Impurity 38 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2S,5R)- (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxyli... 5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester CAS NO.147126-75-8 (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl (2S,5R)-5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate (1R,2S,5R)-Methyl-5(S)-Flurorcytocine-1-Yl-[1,3]-Oxatholane-2Rcarboxylate Emtricitabine SM 5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2 carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester 1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester FCME 75-(4-amino-5-Fluoro-2-oxo-1(2H)-pyrimidine)-1,3-oxothiacyclopentane-2-carboxylic acid 5-Methyl-2-isoPropylcyclohexanol ester 147126-75-8 (intermediate of emtricitabine)