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Doramapimod

Doramapimod structure

CAS No.: 285983-48-4

Chemical Name:: Doramapimod

Synonyms: BIRB 796 (DoraMapiMod);CS-379;CS-1863;BIBR-796;BIRB 796;BIRB 796BS;doramapimod;BIRB-796;BIRB796;DoraMapin BIBR796;BIBR-796(DoraMapiMod)

CBNumber:: CB2855127

Molecular Formula:: C31H37N5O3

Molecular Weight:: 527.66

MDL Number:: MFCD09752957

MOL File:: 285983-48-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-12 08:45:15

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Doramapimod Properties

Melting point	142-143 °C
Boiling point	631.6±55.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
pka	13.47±0.70(Predicted)
form	solid
color	White or off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChIKey	MVCOAUNKQVWQHZ-UHFFFAOYSA-N
SMILES	CC1=CC=C(N2C(NC(NC3=CC=C(OCCN4CCOCC4)C5=C3C=CC=C5)=O)=CC(C(C)(C)C)=N2)C=C1
FDA UNII	HO1A8B3YVV
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H335-H302+H312+H332-H315
Precautionary statements	P301+P312-P302+P352-P305+P351+P338
WGK Germany	WGK 3
HS Code	2934999090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Doramapimod price More Price(95)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	506172	p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem	285983-48-4	10mg	$199	2026-04-30	Buy
TCI Chemical	D6115	Doramapimod	285983-48-4	50MG	$200	2026-04-30	Buy
Cayman Chemical	10460	Doramapimod ≥98%	285983-48-4	1mg	$29	2026-04-30	Buy
Cayman Chemical	10460	Doramapimod ≥98%	285983-48-4	5mg	$55	2026-04-30	Buy
Cayman Chemical	10460	Doramapimod ≥98%	285983-48-4	10mg	$96	2026-04-30	Buy

Product number	Packaging	Price	Buy
506172	10mg	$199	Buy
D6115	50MG	$200	Buy
10460	1mg	$29	Buy
10460	5mg	$55	Buy
10460	10mg	$96	Buy

Doramapimod Chemical Properties, Uses, Production

Description

Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1(IC50=18 nM). Displays anti-inflammatory activity2but differential effects on inflammatory genes3. Cell permeable.

Chemical Properties

Pale Beige Solid

Uses

Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.

Definition

ChEBI: A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.

Synthesis

2,2,2-trichloroethyl 3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-ylcarbamate

317806-87-4

4-[2-(4-NITRONAPHTHALEN-1-YLOXY)ETHYL]MORPHOLINE

317806-88-5

285983-48-4

Step 4 Synthesis of 1-(3-tert-butyl-1-tosyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea (Compound 4): to a mixed solution of 4-(2-((4-nitronaphthalen-1-yl)oxy)ethyl)morpholine (11.18 g, 36.9 mmol) in methanol (90 mL) and THF (30 mL) , 5% palladium/activated carbon (0.500 g) was added. The resulting mixture was stirred at room temperature in a hydrogen atmosphere for 23 hours. Upon completion of the reaction, the insoluble material was removed by filtration and the solvent was evaporated under reduced pressure. The resulting residue was mixed with 2,2,2-trichloroethyl (3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)carbamate (16.1 g, 39.7 mmol), N,N-diisopropylethylamine (8.50 mL) and DMSO (30 mL) and stirred at 60 °C for 18 hours. After completion of the reaction, the reaction solution was cooled to room temperature and saturated brine was added. The aqueous layer was extracted with ethyl acetate and the organic phase was dried with anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=50/50 to ethyl acetate/methanol=90/10) to afford 13.58 g of the target product 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea in 69% yield.

in vitro

birb 796 is a picomolar inhibitor of human p38 map kinase with a 12,000-fold increase in binding affinity. moreover, birb 796 behavors as one of the most potent and slowest dissociating human p38 map kinase inhibitors now known [1].

in vivo

in a lps-stimulated tnf-α synthesis mouse model, a 65% inhibition of tnf-α synthesis was observed when birb 796 was dosed orally at 10 mg/kg. in a model of established collagen-induced arthritis using b10.riii mice, birb 796 showed a 63% inhibition of arthritis severity when dosed orally at 30 mg/kg qd [2].

storage

Store at -20°C

References

[1] CHRISTOPHER PARGELLIS. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site[J]. Nature Structural & Molecular Biology, 2002, 9 4: 268-272. DOI:10.1038/nsb770
[2] J. BRANGER. Anti-Inflammatory Effects of a p38 Mitogen-Activated Protein Kinase Inhibitor During Human Endotoxemia1[J]. The Journal of Immunology, 2002, 1 1: 4070-4077. DOI:10.4049/jimmunol.168.8.4070
[3] H JOOS. Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1β-stimulated human chondrocytes[J]. British Journal of Pharmacology, 2010, 160 5: 1252-1262. DOI:10.1111/j.1476-5381.2010.00760.x

Doramapimod Preparation Products And Raw materials

Raw materials

2,2,2-trichloroethyl 3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-ylcarbamate 4-[2-(4-Nitronaphthalen-1-yloxy)ethyl]morpholine Methanol Hydrogen N,N-Diisopropylethylamine

Dimethyl sulfoxide Tetrahydrofuran

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Preparation Products

Doramapimod Suppliers

Global Suppliers ( 211)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Jinan Trio PharmaTech Co., Ltd.	0531-88811783	sales@trio-pharmatech.com	China	1856	62
Shanghai Kuanghao Chemistry Technology Co., Ltd.	1590082856 15900820856	83219210@qq.com	China	86	57
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-83725681-603		China	4484	50
Shanghai civi chemical technology co.,Ltd	86-21-34053660	sale@labgogo.com	China	9853	52
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
Capot Chemical Co., Ltd	66
Chemsky（shanghai）International Co.,Ltd.	50
Jinan Trio PharmaTech Co., Ltd.	62
Shanghai Kuanghao Chemistry Technology Co., Ltd.	57
S.Z. PhyStandard Bio-Tech. Co., Ltd.	50
Shanghai civi chemical technology co.,Ltd	52
Beijing HuaMeiHuLiBiological Chemical	58

View Latest Price from Doramapimod manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	Doramapimod 285983-48-4		1KG	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2025-04-04	Doramapimod 285983-48-4		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-13	Doramapimod 285983-48-4	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Doramapimod
285983-48-4
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

Doramapimod
285983-48-4
98%
Henan Aochuang Chemical Co.,Ltd.

Doramapimod
285983-48-4
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Doramapimod Spectrum

Doramapimod(285983-48-4)¹HNMR

285983-48-4 (Doramapimod) Related Search:

tert-Butanol Butyl acrylate Cyhalofop-butyl Diethylene glycol monobutyl ether Moroxydine hydrochloride

Butylnaphtalenesulfonic Acid Sodium Salt tert-Butylchlorodiphenylsilane Buprofezin 2-Butoxyethanol Tridemorph

Moroxydine Butyl acetate Dimethomorph MORPHINE 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine

4-(2-Morpholin-4-ylethoxy)aniline 4-(2-Morpholinoethoxy)naphthalen-1-amine BIRB 796 (Doramapimod)

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1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea BIRB 796; BIRB-796; BIRB796; CS-379 BIRB 796 - BIRB 0796 | Doramapimod CS-1863 BIBR-796 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea DoraMapiMod, BIBR-796 BIBR-796(DoraMapiMod) BIRB 796 (DoraMapiMod) BIRB 796BS N-[3-(1,1-DiMethylethyl)-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]urea DoraMapin BIBR796 DoraMapiMod (BIRB-796) BIRB 796 doramapimod Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]- 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea BIRB 796 (Doramapimod) Doramapimod 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea DORAMAPIMOD;BIRB 796;BIRB796 3-[3-Tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea 1-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1h-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea BIRB-796;BIRB796 Doramapimod USP/EP/BP p38 MAP Kinase Inhibitor X BIRB-796 Doramapimod 1-[3-(tert-Butyl)-1-(p-tolyl)-5-pyrazolyl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea Doramapimod, p38 MAPK inhibitor Doramapimod, 10 mM in DMSO 285983-48-4 C31H37N5O3 Anti-cancer&immunity Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators MAPK Inhibitors