ChemicalBook >> CAS DataBase List >>cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate structure

CAS No.: 134071-44-6

Chemical Name:: cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate

Synonyms: CIS-TOSYLATE;Active Ester;Activity Ester;K6 / Cis Tosylate;oxymethyl-1,3-dioxolane;Ketoconazole IMpurity E;KETOCOZOLE EP IMPURITY E;Ketoconazole EP Impurity E;ACTIVE ESTER OF KETOCONZOL;Activity Esterof Ketoconazo

CBNumber:: CB2855192

Molecular Formula:: C21H20Cl2N2O5S

Molecular Weight:: 483.36

MDL Number:: MFCD07367827

MOL File:: 134071-44-6.mol

Last updated:2025-10-10 22:54:41

Product description	Number	Pack Size	Price
cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylp-Tolylsulfonate	D435718	2g	$255
cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylp-Tolylsulfonate	D435718	10g	$1070
cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-tolylsulfonate	FD21680	10g	$1280
(2R,4R) CIS-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE 95.00%	AAA0000074	10G	$2055.9
CIS-Tosylate	B606	1g	$131
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cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Properties

Melting point	120-122°C
Boiling point	665.7±55.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	6.88±0.12(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1/C21H20Cl2N2O5S/c1-15-2-5-18(6-3-15)31(26,27)29-12-17-11-28-21(30-17,13-25-9-8-24-14-25)19-7-4-16(22)10-20(19)23/h2-10,14,17H,11-13H2,1H3/t17-,21-/s3
InChIKey	WAXNIYHZFWRPGS-NTMXNBFVNA-N
SMILES	[C@@]1(OC[C@@H](COS(=O)(=O)C2C=CC(C)=CC=2)O1)(CN1C=NC=C1)C1=CC=C(Cl)C=C1Cl \|&1:0,3,r\|
CAS DataBase Reference	134071-44-6(CAS DataBase Reference)
FDA UNII	644X337Z6T

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P402+P404-P422-P501

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D435718	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylp-Tolylsulfonate	134071-44-6	2g	$255	2021-12-16	Buy
TRC	D435718	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylp-Tolylsulfonate	134071-44-6	10g	$1070	2021-12-16	Buy
Biosynth Carbosynth	FD21680	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-tolylsulfonate	134071-44-6	10g	$1280	2021-12-16	Buy
American Custom Chemicals Corporation	AAA0000074	(2R,4R) CIS-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE 95.00%	134071-44-6	10G	$2055.9	2021-12-16	Buy
AK Scientific	B606	CIS-Tosylate	134071-44-6	1g	$131	2021-12-16	Buy

Product number	Packaging	Price	Buy
D435718	2g	$255	Buy
D435718	10g	$1070	Buy
FD21680	10g	$1280	Buy
AAA0000074	10G	$2055.9	Buy
B606	1g	$131	Buy

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-Tolylsulfonate (Ketoconazole EP Impurity E) is an intermediate in the synthesis of the drug Ketoconazole (K186000).

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Preparation Products And Raw materials

Raw materials

Preparation Products

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Suppliers

Global( 225)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21614	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
NAMCHA CHEMICALS CO.,LTD.	13816860799	vicky.yin@namchachem.com	CHINA	43	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10237	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
NAMCHA CHEMICALS CO.,LTD.	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58

View Lastest Price from cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-10	Ketoconazole Intermediate 1e 134071-44-6	US $59.00 / mg		98.91%	10g	TargetMol Chemicals Inc.
2021-12-22	Cis - (2 - (2, 4 - dichlorobenzene) - 2 - (1 h - imidazole 1 - methyl) - 1, 3 - dioxolane - 4 - base) methanol p-toluene sulfonic acid ester 134071-44-6	US $2.00 / g	1KG	99%	5ton/Month	Qiuxian Baitai New Material Co., LTD
2019-07-06	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate 134071-44-6	US $1.00 / KG	1KG	95%-99%	1000kg	Career Henan Chemical Co

Ketoconazole Intermediate 1e
134071-44-6
US $59.00 / mg
98.91%
TargetMol Chemicals Inc.

Cis - (2 - (2, 4 - dichlorobenzene) - 2 - (1 h - imidazole 1 - methyl) - 1, 3 - dioxolane - 4 - base) methanol p-toluene sulfonic acid ester
134071-44-6
US $2.00 / g
99%
Qiuxian Baitai New Material Co., LTD

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate
134071-44-6
US $1.00 / KG
95%-99%
Career Henan Chemical Co

134071-44-6(cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate)Related Search:

Mebendazole Imidazole Dichlorodiphenylsilane Dichloromethylphenylsilane Phenylphosphonic dichloride

Ketoconazole Ketoconazole Impurity 1 Ketoconazole Impurity 4 Ketoconazole Impurity 9 (Ketoconazole Hydroxymethyl Impurity) Ketoconazole Impurity 6

Ketoconazole Impurity 15 KETOCONAZOLE INTERMEDIATE cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine 2,3-Dehydro Ketoconazole N-Acetylpiperazine-N'-(4-phenol) Ketoconazole

rac-trans-Ketoconazole Ketoconazole Impurity 2 KetoconazoleN-Oxide

1of4

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(P-TOLUENE SULFONYLOXY) METHYL-1,3-DIOXALANE CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-YL METHYL)-1,3-DIOXOLANE-4-YL]-P-METHYLBENZENE SULFONATE CIS-TOSYLATE ACTIVITY ESTEROF KETOCONAZOL CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-YL METHYL)-1,3-DIOXOLANE-4-YL]-P-METHYLBENZENE SULFONATE OR -P-METHYL SULFONATE (KETOCONAZLE INTERMEDIATE) Ketoconazole EP Impurity E Cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-l-ylmethyl)- 1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate (CisTosylate) Ketoconazole Impurity 5（Ketoconazole EP Impurity E） 2-[[2-(2,4-dichlorophenyl)-2-(1-imidazolylmethyl)-1,3-dioxolan-4-yl]methyl]-4-methylbenzenesulfonate CIS-2-(2 4- DICHLOROPHENYL)-2-(1-H-IMIDA ZOLE-YL-METHYL) -1 3-DIOXOLAN-4-YL] METH YL-4-METHYLBENZENESULPHONATE CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(P-TOLUENESULFONYLOXY)METHYL-1,3-DIOXALANE Cis-Tosylate(Cis-2-Dichlorophenyl)2-(Ih-Imidazole-1-Yl)Methyl-4-(P-TolueneSulfonyloxy)Methyl-1,3-Dioxalane CIS-[2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHYL-4-TOLYLSULFONATE Active Ester 1,3-Dioxolane-4-Methanol,2-(2,4-dichlorophenyl)-2-(1H-iMidazol-1-ylMethyl)-,4-(4-Methylbenzenesulfonate), (2R,4R)-rel- (2R,4R)-rel-2-(2,4-Dichlorophenyl)-2-(1H-iMidazol-1-ylMethyl)-1,3-dioxolane-4-Methanol 4-(4-Methylbenzenesulfonate) CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(P-TOLUENE SUIFONYLOXY)METHYL-1,3- Cis-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1yl-methyl)-4-(p-toluensulfonyl) oxymethyl-1,3-dioxolane (Z)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmeth (cis-2-((1H-IMidazol-1-yl)Methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)Methyl 4-Methylbenzenesulfonate Ketoconazole IMpurity E Activity Esterof Ketoconazo Activity Ester ((2R,4R)-rel-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate (cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenz CIS-TOSYLATE, CIS-[2-2,4-DICHLOROPHENYL]-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHYL-4-METHYLBENZENESULPHONATE (2R,4R) CIS-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE CIS-[2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXALAN-4-YL]METHYL-P-TOLYSULFONATE (cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzene Cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate (134071-44-6) [(2RS,4SR)-2-(2,4-Dichlorophenyl)-2 CIS TOSYLATE : Cis-2-(2,4-Dichlorophenyl)-2-(1H-Imidazole-1-yl)Methyl)-4-(p-Toluene Sulfonyloxy)methyl-1,3-Dioxalane) ACTIVE ESTER OF KETOCONZOL Cis - (2 - (2, 4 - dichlorobenzene) - 2 - (1 h - imidazole 1 - methyl) - 1, 3 - dioxolane - 4 - base) methanol p-toluene sulfonic acid ester cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-d... K6 / Cis Tosylate [(2RS,4SR)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-methylbenzenesulfonate KETOCOZOLE EP IMPURITY E Cis-(2-(2,4-Dichlorophenyl)-2-(lH- Imidazot-1- yl-Methyl)-1,3- Dioxolan-4-yl}methyl-4-Methanol CIS-[2-2,4-DICHLOROPHENYL-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4YL]METHYL-4-METHYLBENZENESULPHONATE(Cis Tosylate) Ketoconazole Intermediate 1e (cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzenesul [(2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-methylbenzenesulfonate (2RS,4SR)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-Methylbenzen cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Ketoconazole Imp.E(EP): [(2RS,4SR)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methyl 4-methylbenzene-1-sulfonate 134071-44-6 124071-44-6 C21H20Cl2N2O5S Aromatics Intermediates & Fine Chemicals Pharmaceuticals Heterocycles Intermediates Sulfur & Selenium Compounds Pharmaceutical Intermediates