ChemicalBook >> CAS DataBase List >>cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate structure

CAS No.: 134071-44-6

Chemical Name:: cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate

Synonyms: CIS-TOSYLATE;Active Ester;Activity Ester;K6 / Cis Tosylate;oxymethyl-1,3-dioxolane;Ketoconazole IMpurity E;KETOCOZOLE EP IMPURITY E;Ketoconazole EP Impurity E;ACTIVE ESTER OF KETOCONZOL;Activity Esterof Ketoconazo

CBNumber:: CB2855192

Molecular Formula:: C21H20Cl2N2O5S

Molecular Weight:: 483.37

MDL Number:: MFCD07367827

MOL File:: 134071-44-6.mol

Last updated:2026-05-28 00:50:26

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cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Properties

Melting point	120-122°C
Boiling point	665.7±55.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	6.88±0.12(Predicted)
color	White to Off-White
InChI	InChI=1/C21H20Cl2N2O5S/c1-15-2-5-18(6-3-15)31(26,27)29-12-17-11-28-21(30-17,13-25-9-8-24-14-25)19-7-4-16(22)10-20(19)23/h2-10,14,17H,11-13H2,1H3/t17-,21-/s3
InChIKey	WAXNIYHZFWRPGS-NTMXNBFVNA-N
SMILES	[C@@]1(OC[C@@H](COS(=O)(=O)C2C=CC(C)=CC=2)O1)(CN1C=NC=C1)C1=CC=C(Cl)C=C1Cl \|&1:0,3,r\|
CAS DataBase Reference	134071-44-6(CAS DataBase Reference)
FDA UNII	644X337Z6T

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P402+P404-P422-P501
REACH Registrations	Inactive

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	272046	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-tolylsulfonate Asreported	134071-44-6	500mg	$410	2026-06-03	Buy
Usbiological	272046	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-tolylsulfonate Asreported	134071-44-6	1g	$602	2026-06-03	Buy
Usbiological	272046	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-tolylsulfonate Asreported	134071-44-6	2g	$904	2026-06-03	Buy
Usbiological	272046	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-tolylsulfonate Asreported	134071-44-6	5g	$1396	2026-06-03	Buy
Usbiological	272046	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-tolylsulfonate Asreported	134071-44-6	10g	$2231	2026-06-03	Buy

Product number	Packaging	Price	Buy
272046	500mg	$410	Buy
272046	1g	$602	Buy
272046	2g	$904	Buy
272046	5g	$1396	Buy
272046	10g	$2231	Buy

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-Tolylsulfonate (Ketoconazole EP Impurity E) is an intermediate in the synthesis of the drug Ketoconazole (K186000).

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Preparation Products And Raw materials

Raw materials

Preparation Products

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Suppliers

Global( 234)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Conier Chem & Pharma Co.,Ltd,	023-62879767	sales@conier.com	China	289	56
BTC Pharmaceutical CO. Ltd	+86-15716293042 15716293042	info@btcpharm.com	China	823	55
Shanghai Taijilin Industrial Co., Ltd.	02150630626 17717886015	kate@tajilin.com	China	1340	58
Ningbo Zhenlei Chemical Co.,ltd.	15867601896 15867601896	julie.xiang@zhenleichem.com	China	126	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58

Supplier	Advantage
Conier Chem & Pharma Co.,Ltd,	56
BTC Pharmaceutical CO. Ltd	55
Shanghai Taijilin Industrial Co., Ltd.	58
Ningbo Zhenlei Chemical Co.,ltd.	58
J & K SCIENTIFIC LTD.	76
Jia Xing Isenchem Co.,Ltd	66
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Shanghai T&W Pharmaceutical Co., Ltd.	58

View Lastest Price from cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-11	Ketoconazole Intermediate 1e 134071-44-6	$29.00		99.77%	10g	TargetMol Chemicals Inc.
2021-12-22	Cis - (2 - (2, 4 - dichlorobenzene) - 2 - (1 h - imidazole 1 - methyl) - 1, 3 - dioxolane - 4 - base) methanol p-toluene sulfonic acid ester 134071-44-6	$2.00	1KG	99%	5ton/Month	Qiuxian Baitai New Material Co., LTD
2019-07-06	cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate 134071-44-6	$1.00	1KG	95%-99%	1000kg	Career Henan Chemical Co

Ketoconazole Intermediate 1e
134071-44-6
$29.00
99.77%
TargetMol Chemicals Inc.

Cis - (2 - (2, 4 - dichlorobenzene) - 2 - (1 h - imidazole 1 - methyl) - 1, 3 - dioxolane - 4 - base) methanol p-toluene sulfonic acid ester
134071-44-6
$2.00
99%
Qiuxian Baitai New Material Co., LTD

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate
134071-44-6
$1.00
95%-99%
Career Henan Chemical Co

134071-44-6(cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate)Related Search:

Mebendazole Imidazole Dichlorodiphenylsilane Dichloromethylphenylsilane Phenylphosphonic dichloride

Ketoconazole Ketoconazole Impurity 1 Ketoconazole Impurity 4 Ketoconazole Impurity 9 (Ketoconazole Hydroxymethyl Impurity) Ketoconazole Impurity 6

Ketoconazole Impurity 15 KETOCONAZOLE INTERMEDIATE cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine 2,3-Dehydro Ketoconazole N-Acetylpiperazine-N'-(4-phenol) Ketoconazole

rac-trans-Ketoconazole Ketoconazole Impurity 2 KetoconazoleN-Oxide

1of4

cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(P-TOLUENE SULFONYLOXY) METHYL-1,3-DIOXALANE CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-YL METHYL)-1,3-DIOXOLANE-4-YL]-P-METHYLBENZENE SULFONATE ACTIVITY ESTEROF KETOCONAZOL CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-YL METHYL)-1,3-DIOXOLANE-4-YL]-P-METHYLBENZENE SULFONATE OR -P-METHYL SULFONATE (KETOCONAZLE INTERMEDIATE) Ketoconazole EP Impurity E Cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-l-ylmethyl)- 1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate (CisTosylate) Ketoconazole Impurity 5（Ketoconazole EP Impurity E） 2-[[2-(2,4-dichlorophenyl)-2-(1-imidazolylmethyl)-1,3-dioxolan-4-yl]methyl]-4-methylbenzenesulfonate CIS-2-(2 4- DICHLOROPHENYL)-2-(1-H-IMIDA ZOLE-YL-METHYL) -1 3-DIOXOLAN-4-YL] METH YL-4-METHYLBENZENESULPHONATE CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(P-TOLUENESULFONYLOXY)METHYL-1,3-DIOXALANE Cis-Tosylate(Cis-2-Dichlorophenyl)2-(Ih-Imidazole-1-Yl)Methyl-4-(P-TolueneSulfonyloxy)Methyl-1,3-Dioxalane CIS-[2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHYL-4-TOLYLSULFONATE 1,3-Dioxolane-4-Methanol,2-(2,4-dichlorophenyl)-2-(1H-iMidazol-1-ylMethyl)-,4-(4-Methylbenzenesulfonate), (2R,4R)-rel- (2R,4R)-rel-2-(2,4-Dichlorophenyl)-2-(1H-iMidazol-1-ylMethyl)-1,3-dioxolane-4-Methanol 4-(4-Methylbenzenesulfonate) CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(P-TOLUENE SUIFONYLOXY)METHYL-1,3- Cis-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1yl-methyl)-4-(p-toluensulfonyl) oxymethyl-1,3-dioxolane (Z)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmeth (cis-2-((1H-IMidazol-1-yl)Methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)Methyl 4-Methylbenzenesulfonate Ketoconazole IMpurity E Activity Esterof Ketoconazo Activity Ester ((2R,4R)-rel-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate (cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenz CIS-TOSYLATE, CIS-[2-2,4-DICHLOROPHENYL]-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHYL-4-METHYLBENZENESULPHONATE (2R,4R) CIS-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE CIS-[2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXALAN-4-YL]METHYL-P-TOLYSULFONATE (cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzene Cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate (134071-44-6) [(2RS,4SR)-2-(2,4-Dichlorophenyl)-2 CIS TOSYLATE : Cis-2-(2,4-Dichlorophenyl)-2-(1H-Imidazole-1-yl)Methyl)-4-(p-Toluene Sulfonyloxy)methyl-1,3-Dioxalane) ACTIVE ESTER OF KETOCONZOL Cis - (2 - (2, 4 - dichlorobenzene) - 2 - (1 h - imidazole 1 - methyl) - 1, 3 - dioxolane - 4 - base) methanol p-toluene sulfonic acid ester cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-d... K6 / Cis Tosylate [(2RS,4SR)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-methylbenzenesulfonate KETOCOZOLE EP IMPURITY E Cis-(2-(2,4-Dichlorophenyl)-2-(lH- Imidazot-1- yl-Methyl)-1,3- Dioxolan-4-yl}methyl-4-Methanol CIS-[2-2,4-DICHLOROPHENYL-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4YL]METHYL-4-METHYLBENZENESULPHONATE(Cis Tosylate) Ketoconazole Intermediate 1e (cis-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzenesul [(2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-methylbenzenesulfonate (2RS,4SR)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-Methylbenzen cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Ketoconazole Imp.E(EP): [(2RS,4SR)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methyl 4-methylbenzene-1-sulfonate CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOL METHYL-4-METHYI CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-... CIS-[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YLJMETHYL-4-METHYLBENZE CIS·[2-(2,4-DICHLOROPHENYL)-2-(TH-IMIDAZCL-1-YLMETHYL)-1,3-DIOXOLAN-4-YLJMETHYL-4-METHYLBENZE cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methanolp-toluenesulfonate Active Ester CIS-TOSYLATE 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-, 4-methylbenzenesulfonate (ester),?cis- (ZCI) 134071-44-6 124071-44-6 C21H20Cl2N2O5S Aromatics