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10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate

10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate structure

CAS No.: 13115-40-7

Chemical Name:: 10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate

Synonyms: Dimethothiazine mesylate;Bonpac;RP 8599;IL-6302;Calsekin;Banistyl;Yoristen;Promaquid;Migristene;Neomestine

CBNumber:: CB2921745

Molecular Formula:: C20H29N3O5S3

Molecular Weight:: 487.65636

MDL Number:: MFCD01706746

MOL File:: 13115-40-7.mol

MSDS File:: SDS

Last updated:2026-04-21 10:31:43

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10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate Properties

FDA UNII	B28V86NGNK

SAFETY

Risk and Safety Statements

Toxicity	LD50 oral in rat: 1320mg/kg

10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate Chemical Properties, Uses, Production

Originator

Migristene,Rhone Poulenc,France,1965

Uses

Dimethothiazine mesylate is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine mesylate can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine mesylate can be used to research hemicrania and spasticity[1][2][3].

Definition

ChEBI: Dimethothiazine mesylate is a member of phenothiazines, a sulfonamide and a methanesulfonate salt.

Manufacturing Process

A solution of 3-dimethylsulfamoylphenthiazine (10 grams) in xylene (100 cc) is heated under reflux for 3 hours with sodium amide (1.5 grams). A solution of 1-dimethylamino-2-chloropropane (4.4 grams) in anhydrous xylene (30 cc) is then added and heating under reflux continued for 4 hours. After cooling the suspension obtained is agitated with water (50 cc) and ether (30 cc). The aqueous layer is separated and the basic products are extracted from the organic phase with 10% hydrochloric acid. The xylene layer is discarded and, after the combined acid solutions have been made alkaline with sodium carbonate, the base is extracted with chloroform. The chloroform solutions are then washed with water and dried over anhydrous potassium carbonate. After evaporation of the solvent under reduced pressure there is obtained a crude resinous base (9.7 grams).
On the addition of ethereal hydrogen chloride to a solution of the base in isopropanol and recrystallization from anhydrous ethanol of the salt formed, there is obtained 3-dimethylsulfamoyl-10-(2-dimethylaminopropyl) phenthiazine hydrochloride (2.1 grams), MP 214°C with decomposition. After dissolving the product in anhydrous ethanol and adding methanesulfonic acid there is obtained fonazine mesylate.

References

[1] Nattero G, et al. Use of dimethothiazine in the prevention of hemicrania. Minerva Med. 1977 Mar 17;68(13):839-45. PMID:321991
[2] Maxwell DR, Rhodes KF. The effects of dimethothiazine on muscle spindle activity in the decerebrate cat. Br J Pharmacol. 1970 Jul;39(3):520-32. DOI:10.1111/j.1476-5381.1970.tb10360.x
[3] Griffiths MI, et al. The use of dimethothiazine in the treatment of childhood cerebral palsy. Dev Med Child Neurol. 1973 Feb;15(1):25-32. DOI:10.1111/j.1469-8749.1973.tb04862.x

10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate Preparation Products And Raw materials

Raw materials

Sodium amide Hydrochloric acid Methanesulfonic acid 1-Dimethylamino-2-chloropropane

Preparation Products

10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate Suppliers

Global Suppliers ( 3)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Latest Price from 10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-20	Fonazine mesylate 13115-40-7	$1670.00-2800.00			10g	TargetMol Chemicals Inc.

Fonazine mesylate
13115-40-7
$1670.00-2800.00
TargetMol Chemicals Inc.

10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate Spectrum

10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate(13115-40-7)MS 10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate(13115-40-7)¹HNMR 10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate(13115-40-7)¹³CNMR 10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate(13115-40-7)IR1 10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate(13115-40-7)IR2

10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate 10-[2-(Dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide methanesulfonate 10H-Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl-, monomethanesulfonate 8599RP mesylate Banistyl Bonpac Calsekin Dimethothiazine methanesulfonate dimetotiazine mesilate Fonazine mesylate Fonazine methanesulfonate IL 6302 mesylate Migristene Neomestine Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl-, monomethanesulfonate (8CI) Promaquid RP 8599 RP 8599 mesylate Yoristen IL-6302 N,N-Dimethyl-10-[2-(dimethylamino)propyl]-10H-phenothiazine-2-sulfonamide·methanesulfonic acid Dimethothiazine mesylate 13115-40-7