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ChemicalBook >> CAS DataBase List >>2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)-

2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)-

2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)- Structure
2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)- structure
CAS No.
1957278-93-1
Chemical Name:
2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)-
Synonyms
S201086);GLPG1972;Aldumastat;Aldumastat (GLPG1972;Aldumastat, 10 mM in DMSO;5(S)-Cyclopropyl-5-{3-[4-(3,5-difluoro-phenyl)-3(S)-methyl-piperazin-1-yl]-3-oxo-propyl}-imidazolidine-2,4-dione;5(R)-Cyclopropyl-5-{3-[4-(3,5-difluoro-phenyl)-3(R)-methyl-piperazin-1-yl]-3-oxo-propyl}-imidazolidine-2,4-dione;2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)-
CBNumber:
CB29270497
Molecular Formula:
C20H24F2N4O3
Molecular Weight:
406.43
MDL Number:
MFCD31690991
MOL File:
1957278-93-1.mol
Last updated:2025-04-18 09:51:58
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2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)- Properties

Density 1.336±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (246.04 mM; Need ultrasonic)
form Solid
pka 8.79±0.10(Predicted)
color White to off-white
FDA UNII EI4HZ6P03E

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)- Chemical Properties,Uses,Production

Uses

Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research[1].

in vivo

GLPG1972 (oral gavage; 5 mg/kg; single dose) displays a favorable PK profile in mice, rats, and dogs. The oral availability (F%) for mice, rats, and dogs are 25%, 58% and 97%, respectively[1].

IC 50

ADAMTS-5: 19 nM (IC50); ADAMTS-4: 156 nM (IC50); MMP-2: 1158 nM (IC50); MMP-14: >3198 nM (IC50)

References

[1] Franck Brebion, et al. Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis. J Med Chem. 2021 Mar 25;64(6):2937-2952. DOI:10.1021/acs.jmedchem.0c02008

2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)- Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32284 58
JW & Y Pharmlab Co., Ltd. 021-64340559 13651849907 xinyu_shi@jwypharmlab.com.cn China 6861 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5528 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Jilin Chinese Academy of Sciences-yanshen Technology 18143011203 ET-market@chemextension.com China 28034 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
JW & Y Pharmlab Co., Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
TargetMol Chemicals Inc. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58

View Lastest Price from 2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Aldumastat pictures 2024-10-24 Aldumastat
1957278-93-1
 US $299.00 / mg 99.87% 10g TargetMol Chemicals Inc.
  • Aldumastat pictures
  • Aldumastat
    1957278-93-1
  • US $299.00 / mg
  • 99.87%
  • TargetMol Chemicals Inc.
2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)- 5(R)-Cyclopropyl-5-{3-[4-(3,5-difluoro-phenyl)-3(R)-methyl-piperazin-1-yl]-3-oxo-propyl}-imidazolidine-2,4-dione Aldumastat GLPG1972 Aldumastat (GLPG1972 S201086) 5(S)-Cyclopropyl-5-{3-[4-(3,5-difluoro-phenyl)-3(S)-methyl-piperazin-1-yl]-3-oxo-propyl}-imidazolidine-2,4-dione Aldumastat, 10 mM in DMSO 1957278-93-1