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1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-

1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- structure

CAS No.: 2509360-22-7

Chemical Name:: 1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-

Synonyms: Thalidomide-4-O-C3-NH2;4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-(3-Aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-;4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

CBNumber:: CB29310524

Molecular Formula:: C16H17N3O5

Molecular Weight:: 331.32

MDL Number:: MFCD32063453

MOL File:: 2509360-22-7.mol

Last updated:2025-04-18 09:51:57

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1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Properties

Boiling point	617.9±55.0 °C(Predicted)
Density	1.425±0.06 g/cm3(Predicted)
pka	10.70±0.40(Predicted)

1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
aablocks	AA01V34G	4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 95%	2509360-22-7	250mg	$1103	2026-05-31	Buy
aablocks	AA01V34G	4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 95%	2509360-22-7	1g	$1189	2026-05-31	Buy
aablocks	AA01V34G	4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 95%	2509360-22-7	5g	$3257	2026-05-31	Buy

Product number	Packaging	Price	Buy
AA01V34G	250mg	$1103	Buy
AA01V34G	1g	$1189	Buy
AA01V34G	5g	$3257	Buy

1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties,Uses,Production

Uses

Thalidomide-O-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7909	65
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1644	58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD	025-86755008 17751752005	hszhang@bestfluorodrug.com	China	2357	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	043180534350 19917294565	et@chemextension.com	China	4446	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	9067	58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD	025-86755008 17751752005	hszhang@bestfluorodrug.com	China	2871	58
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	info@chemextension.com	China	42052	58

Supplier	Advantage
Daicel Chiral Technologies (China)CO.,LTD	65
Jilin Province Woda Biotechnology Co., Ltd.	58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD	58
Jilin Chinese Academy of Sciences-yanshen Technology	58

2509360-22-7(1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-)Related Search:

4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-Piperazinepropanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]amino]-4-oxo-Butanoic acid 4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1Hisoindol-5-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid, Thalidomide-NH-PEG2-C2-NH2 (TFA)

5-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]- 5-[(8-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

5-[(5-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 5-[(7-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Thalidomide-O-C10-NH2 1H-Isoindole-1,3(2H)-dione, 5-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)- 3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)propanoic acid

5-[(3-aminopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Thalidomide-O-C5-NH2 Thalidomide-4-O-C8-NH2

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1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- 4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione Thalidomide-4-O-C3-NH2 4-(3-Aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione 4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 2509360-22-7